Featured Publications
Anti-Hypertensive Medications and Cardiovascular Events in Older Adults with Multiple Chronic Conditions
Tinetti ME, Han L, McAvay GJ, Lee DS, Peduzzi P, Dodson JA, Gross CP, Zhou B, Lin H. Anti-Hypertensive Medications and Cardiovascular Events in Older Adults with Multiple Chronic Conditions. PLOS ONE 2014, 9: e90733. PMID: 24614535, PMCID: PMC3948696, DOI: 10.1371/journal.pone.0090733.Peer-Reviewed Original ResearchConceptsMultiple chronic conditionsAnti-hypertensive treatmentCardiovascular eventsAnti-hypertensive medicationsHigh-intensity groupChronic conditionsOlder adultsHazard ratioPropensity scoreIntensity groupStandardized daily doseCommunity-living participantsPropensity score adjustmentCV eventsMedication intensityLess comorbidityDaily doseRandomized trialsMAIN OUTCOMERepresentative cohortScore adjustmentSurvey cohortRCT resultsCohortMortalityShared risk factors for falls, incontinence, and functional dependence. Unifying the approach to geriatric syndromes.
Tinetti ME, Inouye SK, Gill TM, Doucette JT. Shared risk factors for falls, incontinence, and functional dependence. Unifying the approach to geriatric syndromes. JAMA 1995, 273: 1348-53. PMID: 7715059, DOI: 10.1001/jama.273.17.1348.Peer-Reviewed Original ResearchMeSH KeywordsAccidental FallsActivities of Daily LivingAgedAged, 80 and overAnxietyCausalityCognitionCohort StudiesGeriatric AssessmentHearingHumansLogistic ModelsMultivariate AnalysisNeuropsychological TestsNutritional Physiological PhenomenaPhysical FitnessPsychomotor PerformanceRisk FactorsUrinary IncontinenceVision, OcularConceptsUrinary incontinenceGeriatric syndromesMore basic activitiesProportion of participantsRisk factorsIncontinenceDaily livingDepression scoresSyndromeGeneral communityCompensatory abilityArm strengthBasic activitiesSignificant increaseHigh anxietyImpairmentMultiple areasNew HavenYearsParticipantsFallFactorsPredisposesCohortBaseline
1999
The Combined Effects of Baseline Vulnerability and Acute Hospital Events on the Development of Functional Dependence Among Community-Living Older Persons
Gill T, Williams C, Tinetti M. The Combined Effects of Baseline Vulnerability and Acute Hospital Events on the Development of Functional Dependence Among Community-Living Older Persons. The Journals Of Gerontology Series A 1999, 54: m377-m383. PMID: 10462171, DOI: 10.1093/gerona/54.7.m377.Peer-Reviewed Original ResearchConceptsCommunity-living older personsValidation cohortDevelopment cohortOlder personsBaseline vulnerabilityHospital eventsPopulation-based cohort studyAcute care hospital admissionsCommunity-living personsHigh-risk groupSkilled nursing facilitiesYears of ageCohort studyHospital admissionPrimary outcomeComparable personsNew disabilityDaily livingNursing facilitiesCohortCognitive statusHigh-vulnerability groupPrecipitating eventsPhysical performanceAdmission
1998
Development of a Test Battery to Identify Older Drivers at Risk for Self‐Reported Adverse Driving Events
Marottoli R, Richardson E, Stowe M, Miller E, Brass L, Cooney L, Tinetti M. Development of a Test Battery to Identify Older Drivers at Risk for Self‐Reported Adverse Driving Events. Journal Of The American Geriatrics Society 1998, 46: 562-568. PMID: 9588368, DOI: 10.1111/j.1532-5415.1998.tb01071.x.Peer-Reviewed Original ResearchConceptsAdverse driving eventsFunctional abilityTest batteryLimited neck rotationSafety cohortAdverse eventsCohort studyVisual acuityNumber cancellation taskOutcome measuresNeck rotationMean periodParticipants' homesOlder personsClinician's officeParticipants' historySafety interviewsCohortBattery of testsPossible interventionsEtiology of impairmentsProbability sampleImpairmentOlder driversCharacteristic analysis
1997
The Role of Change in Physical Performance in Determining Risk for Dependence in Activities of Daily Living Among Nondisabled Community-Living Elderly Persons
Gill T, Williams C, de Leon C, Tinetti M. The Role of Change in Physical Performance in Determining Risk for Dependence in Activities of Daily Living Among Nondisabled Community-Living Elderly Persons. Journal Of Clinical Epidemiology 1997, 50: 765-772. PMID: 9253386, DOI: 10.1016/s0895-4356(97)00065-6.Peer-Reviewed Original ResearchConceptsUseful prognostic informationADL dependencePhysical performanceElderly personsPrognostic informationDaily livingCommunity-living elderly personsSingle assessmentLarge representative cohortAssessment of changesFuture disabilityBaseline interviewRepresentative cohortPowerful predictorRole of changesRiskParticipantsShort intervalsYearsAssessmentBaseline performancePersonsCohortYear interviewsADLA Predictive Model for ADL Dependence in Community‐Living Older Adults Based on a Reduced Set of Cognitive Status Items
Gill T, Williams C, Richardson E, Berkman L, Tinetti M. A Predictive Model for ADL Dependence in Community‐Living Older Adults Based on a Reduced Set of Cognitive Status Items. Journal Of The American Geriatrics Society 1997, 45: 441-445. PMID: 9100712, DOI: 10.1111/j.1532-5415.1997.tb05168.x.Peer-Reviewed Original ResearchConceptsADL dependenceDevelopment cohortValidation cohortPresence of impairmentsPopulation-based cohort studyMini-Mental State Examination (MMSE) itemCommunity-living older adultsCommunity-living personsSelf-reported ADLOlder person's riskYears of ageCohort studyResearch nursesMultivariable analysisRisk groupsBaseline interviewInitial cohortStratified subjectsSeparate cohortCohortPerson's riskGeneral communityOlder adultsCognitive AssessmentComparable subjectsDriving Cessation and Increased Depressive Symptoms: Prospective Evidence from the New Haven EPESE
Marottoli R, de Leon C, Glass T, Williams C, Cooney L, Berkman L, Tinetti M. Driving Cessation and Increased Depressive Symptoms: Prospective Evidence from the New Haven EPESE. Journal Of The American Geriatrics Society 1997, 45: 202-206. PMID: 9033520, DOI: 10.1111/j.1532-5415.1997.tb04508.x.Peer-Reviewed Original ResearchConceptsHealth-related factorsDepressive symptomsEpidemiologic Studies Depression ScaleEffect of cessationCohort studyMultivariable analysisOlder driversProspective evidenceElderly cohortEpidemiologic studiesMedical conditionsPotential confoundingAlternative transportation strategiesSymptomsCessationStrongest predictorNew HavenUrban communitiesFactorsCohortEPESEActive drivers
1995
Shared Risk Factors for Falls, Incontinence, and Functional Dependence: Unifying the Approach to Geriatric Syndromes
Tinetti M, Inouye S, Gill T, Doucette J. Shared Risk Factors for Falls, Incontinence, and Functional Dependence: Unifying the Approach to Geriatric Syndromes. JAMA 1995, 273: 1348-1353. DOI: 10.1001/jama.1995.03520410042024.Peer-Reviewed Original ResearchGeriatric syndromesUrinary incontinenceMore basic activitiesPopulation-based cohortProportion of participantsRisk factorsIncontinenceDaily livingDepression scoresSyndromeGeneral communityCompensatory abilityArm strengthBasic activitiesSignificant increaseHigh anxietyImpairmentMultiple areasNew HavenYearsParticipantsFallFactorsPredisposesCohort