2017
Maternal smoking and autism spectrum disorder: meta-analysis with population smoking metrics as moderators
Jung Y, Lee AM, McKee SA, Picciotto MR. Maternal smoking and autism spectrum disorder: meta-analysis with population smoking metrics as moderators. Scientific Reports 2017, 7: 4315. PMID: 28659613, PMCID: PMC5489536, DOI: 10.1038/s41598-017-04413-1.Peer-Reviewed Original ResearchConceptsMale smoking prevalenceMaternal smokingNicotine exposureSmoking prevalenceAdult male smoking prevalenceSignificant associationPostnatal nicotine exposureUtero nicotine exposureAutism spectrum disorderRandom-effects modelWorld Health Organization dataMeta-regression analysisSmoking metricsSmoke exposureSecondhand smokingPooled ORsObservational studySpectrum disorderSmokingBrain developmentControl participantsPrevalenceASD riskExposureAssociationEffect of doxazosin on stress reactivity and the ability to resist smoking
Verplaetse TL, Weinberger AH, Oberleitner LM, Smith KM, Pittman BP, Shi JM, Tetrault JM, Lavery ME, Picciotto MR, McKee SA. Effect of doxazosin on stress reactivity and the ability to resist smoking. Journal Of Psychopharmacology 2017, 31: 830-840. PMID: 28440105, PMCID: PMC5823502, DOI: 10.1177/0269881117699603.Peer-Reviewed Original ResearchConceptsTobacco cravingCortisol levelsSubsequent ad libitum smokingEffects of doxazosinAd libitum smokingNumber of cigarettesNicotine-motivated behaviorsSmoking lapse behaviorΑ1-adrenergic antagonistNicotine-deprived smokersTitration periodPreclinical findingsSmoking cessationNoradrenergic systemTreatment strategiesDoxazosinSmoking behaviorSmokingHuman laboratoryPhysiologic reactivityPilot studyStress reactivityEffects of stressCigarettesStress imagery
2016
Evaluation of the Nicotinic Acetylcholine Receptor-Associated Proteome at Baseline and Following Nicotine Exposure in Human and Mouse Cortex
McClure-Begley TD, Esterlis I, Stone KL, Lam TT, Grady SR, Colangelo CM, Lindstrom JM, Marks MJ, Picciotto MR. Evaluation of the Nicotinic Acetylcholine Receptor-Associated Proteome at Baseline and Following Nicotine Exposure in Human and Mouse Cortex. ENeuro 2016, 3: eneuro.0166-16.2016. PMID: 27559543, PMCID: PMC4985585, DOI: 10.1523/eneuro.0166-16.2016.Peer-Reviewed Original ResearchConceptsPutative interacting proteinsQuantitative proteomic assessmentProtein-protein interactionsTemporal cortex tissueChaperone familyMood disordersInteracting proteinProtein complexesPresynaptic neurotransmitter releaseNovel etiological mechanismsNicotine exposureProteomic assessmentProteomeNicotinic acetylcholine receptorsMouse cortexProteinHigh-affinity nAChRsΒ2 subunitCortex of miceMaintenance of smokingNew treatment targetsResult of smokingNeurotransmitter releaseAcetylcholine receptorsPrimary functionCHRNA4 and ANKK1 Polymorphisms Influence Smoking-Induced Nicotinic Acetylcholine Receptor Upregulation
Esterlis I, Hillmer AT, Bois F, Pittman B, McGovern E, O’Malley S, Picciotto MR, Yang BZ, Gelernter J, Cosgrove KP. CHRNA4 and ANKK1 Polymorphisms Influence Smoking-Induced Nicotinic Acetylcholine Receptor Upregulation. Nicotine & Tobacco Research 2016, 18: 1845-1852. PMID: 27611310, PMCID: PMC4978979, DOI: 10.1093/ntr/ntw081.Peer-Reviewed Original ResearchMeSH KeywordsAdultCase-Control StudiesCorpus StriatumFemaleHumansIodine RadioisotopesMalePolymorphism, Single NucleotideProtein Serine-Threonine KinasesReceptors, NicotinicSmokingSmoking CessationSmoking PreventionTobacco Use DisorderTomography, Emission-Computed, Single-PhotonUp-RegulationWhite PeopleConceptsSmoking-induced changesWeeks of abstinenceNAChR availabilitySmoking cessationNicotine dependenceSex-matched nonsmokersTomography brain scanSingle nucleotide polymorphismsNicotinic acetylcholine receptorsSingle photon emissionDays of abstinenceNonsmoker levelsTobacco smokingReceptor upregulationBlood samplesAcetylcholine receptorsBrain scansCHRNA4 variantsCortical regionsSmokersCarrier statusExtended abstinenceAbstinencePersonalized programsNonsmokers
2014
A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation
McKee SA, Potenza MN, Kober H, Sofuoglu M, Arnsten A, Picciotto MR, Weinberger AH, Ashare R, Sinha R. A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation. Journal Of Psychopharmacology 2014, 29: 300-311. PMID: 25516371, PMCID: PMC4376109, DOI: 10.1177/0269881114562091.Peer-Reviewed Original ResearchConceptsPlacebo-treated subjectsFunctional magnetic resonance imagingCentral noradrenergic pathwaysPrefrontal cognitive dysfunctionSystolic blood pressureClinical outcome dataAd libitum smokingNovel translational approachStress-induced reinstatementMagnetic resonance imagingNicotine-deprived smokersBlood pressureNoradrenergic pathwaysAgonist guanfacineCognitive dysfunctionTreatment periodTobacco cravingQuit attemptsOutcome dataSmokingComplete abstinenceCortisol levelsTranslational investigationsCigarette useGuanfacine
2013
In Vivo Evidence for β2 Nicotinic Acetylcholine Receptor Subunit Upregulation in Smokers as Compared With Nonsmokers With Schizophrenia
Esterlis I, Ranganathan M, Bois F, Pittman B, Picciotto MR, Shearer L, Anticevic A, Carlson J, Niciu MJ, Cosgrove KP, D’Souza D. In Vivo Evidence for β2 Nicotinic Acetylcholine Receptor Subunit Upregulation in Smokers as Compared With Nonsmokers With Schizophrenia. Biological Psychiatry 2013, 76: 495-502. PMID: 24360979, PMCID: PMC4019710, DOI: 10.1016/j.biopsych.2013.11.001.Peer-Reviewed Original ResearchConceptsLower β2Negative symptomsCortical regionsLower receptor availabilitySelf-medicate symptomsComparison groupLower negative symptomsHigh β2Executive controlExecutive functionNicotine cravingSex-matched comparison subjectsMood assessmentBrain regionsWorse performanceComparison subjectsDiagnosis interactionLimited brain regionsNicotinic acetylcholine receptorsSchizophreniaSingle photon emissionNAChR availabilityActive smokingTobacco smokingPoor outcomeMediating Role of Stress Reactivity in the Effects of Prenatal Tobacco Exposure on Childhood Mental Health Outcomes
Park A, O’Malley S, King SL, Picciotto MR. Mediating Role of Stress Reactivity in the Effects of Prenatal Tobacco Exposure on Childhood Mental Health Outcomes. Nicotine & Tobacco Research 2013, 16: 174-185. PMID: 23990474, PMCID: PMC3880234, DOI: 10.1093/ntr/ntt131.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChildChild Behavior DisordersChild, PreschoolChi-Square DistributionConfounding Factors, EpidemiologicFemaleHumansLongitudinal StudiesMaleMental DisordersMothersPregnancyPrenatal Exposure Delayed EffectsProspective StudiesRisk FactorsSmokingStress, PsychologicalSurveys and QuestionnairesUnited KingdomYoung AdultConceptsMental health outcomesStressful life eventsPrenatal tobacco exposureAdverse mental health outcomesStress reactivityLife eventsMothers' ratingsChildhood mental health outcomesTobacco exposureChildren's reactivityHealth outcomesMiddle childhoodEmotional problemsAvon Longitudinal StudyDifficulties QuestionnairePreschool ageAge 4Mental healthLongitudinal studyProspective population-based studyLarge prospective population-based studyPsychiatric symptomsEarly childhoodPopulation-based studyRatingsChanges in the Cholinergic System between Bipolar Depression and Euthymia as Measured with [123I]5IA Single Photon Emission Computed Tomography
Hannestad JO, Cosgrove KP, DellaGioia NF, Perkins E, Bois F, Bhagwagar Z, Seibyl JP, McClure-Begley TD, Picciotto MR, Esterlis I. Changes in the Cholinergic System between Bipolar Depression and Euthymia as Measured with [123I]5IA Single Photon Emission Computed Tomography. Biological Psychiatry 2013, 74: 768-776. PMID: 23773793, PMCID: PMC3805761, DOI: 10.1016/j.biopsych.2013.04.004.Peer-Reviewed Original ResearchConceptsBipolar depressionControl subjectsCholinergic systemSingle photon emissionBipolar disorderAge-matched control subjectsEndogenous acetylcholine levelsNew treatment targetsNicotinic acetylcholine receptorsPhoton emissionLow receptor numbersClinical characteristicsEndogenous acetylcholineDepressive episodeAcetylcholine levelsTomography scanMajor depressionReceptor numberTemporal cortexNAChR numbersTreatment targetsAcetylcholine receptorsControl groupBrain regionsLower β2Nicotine, Striatum, and Reward
Addy NA, Picciotto MR. Nicotine, Striatum, and Reward. Biological Psychiatry 2013, 73: 205-206. PMID: 23337022, DOI: 10.1016/j.biopsych.2012.11.001.Peer-Reviewed Original Research
2012
Nicotine, Food Intake, and Activation of POMC Neurons
Picciotto MR, Mineur YS. Nicotine, Food Intake, and Activation of POMC Neurons. Neuropsychopharmacology 2012, 38: 245-245. PMID: 23147487, PMCID: PMC3521975, DOI: 10.1038/npp.2012.163.Peer-Reviewed Original ResearchSex Differences in Availability of β2*-Nicotinic Acetylcholine Receptors in Recently Abstinent Tobacco Smokers
Cosgrove KP, Esterlis I, McKee SA, Bois F, Seibyl JP, Mazure CM, Krishnan-Sarin S, Staley JK, Picciotto MR, O’Malley S. Sex Differences in Availability of β2*-Nicotinic Acetylcholine Receptors in Recently Abstinent Tobacco Smokers. JAMA Psychiatry 2012, 69: 418-427. PMID: 22474108, PMCID: PMC3508698, DOI: 10.1001/archgenpsychiatry.2011.1465.Peer-Reviewed Original ResearchMeSH KeywordsAdultAzetidinesBehavior, AddictiveBrainDepressionEstradiolFemaleFunctional NeuroimagingHumansIodine RadioisotopesMaleNicotinic AntagonistsProgesteronePyridinesRadioligand AssayReceptors, NicotinicSex CharacteristicsSmokingSubstance Withdrawal SyndromeTomography, Emission-Computed, Single-PhotonConceptsNAChR availabilityFemale smokersTobacco smokersNicotinic acetylcholine receptorsFemale nonsmokersProgesterone levelsAcetylcholine receptorsFemale sex steroid hormonesSex differencesSex steroid hormone levelsAbstinent tobacco smokersSex-matched nonsmokersTobacco smoking effectsMagnetic resonance imaging studyAge-matched malesEquilibrium distribution volumeEffects of nicotineSex steroid hormonesSteroid hormone levelsUnderlying neurochemical mechanismsResonance imaging studySingle photon emissionDays of abstinenceIA SPECTNicotine therapy
2010
Examining antidepressant drug response by smoking status: why is it important and how often is it done?
Weinberger AH, McKee SA, Picciotto MR, Mazure CM. Examining antidepressant drug response by smoking status: why is it important and how often is it done? Journal Of Psychopharmacology 2010, 25: 1269-1276. PMID: 21169392, PMCID: PMC3256572, DOI: 10.1177/0269881110389347.Peer-Reviewed Original ResearchConceptsSmoking statusImpact of smokingEffect of smokingNeurobiology of depressionAntidepressant treatment outcomeAntidepressant drug responsePharmacological intervention studiesPharmacological trialsClinical trialsTreatment outcomesMEDLINE searchNicotine dependenceSmokingTargeted treatmentIntervention studiesTreatment studiesDrug responseDepressionOutcomesTreatment researchTrialsStatusTreatmentAntidepressantsPharmacotherapyBrain β2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhaler
Esterlis I, Mitsis EM, Batis JC, Bois F, Picciotto MR, Stiklus SM, Kloczynski T, Perry E, Seibyl JP, McKee S, Staley JK, Cosgrove KP. Brain β2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhaler. The International Journal Of Neuropsychopharmacology 2010, 14: 389-398. PMID: 21029513, PMCID: PMC3510008, DOI: 10.1017/s1461145710001227.Peer-Reviewed Original ResearchConceptsNicotine inhalerWithdrawal symptomsReceptor occupancyTobacco smokingLow nicotine cigarettesAdministration of nicotineHigh receptor occupancyDoses of nicotineNicotinic acetylcholine receptorsInhaler useTobacco smokersBaseline scanRegular cigarettesInhalerConstant infusionAcetylcholine receptorsSPECT studiesCigarettesSymptomsBeta 2Significant decreaseNicotineSignificant differencesSmokingNAChRs
2009
Varenicline Reduces Alcohol Self-Administration in Heavy-Drinking Smokers
McKee SA, Harrison EL, O'Malley SS, Krishnan-Sarin S, Shi J, Tetrault JM, Picciotto MR, Petrakis IL, Estevez N, Balchunas E. Varenicline Reduces Alcohol Self-Administration in Heavy-Drinking Smokers. Biological Psychiatry 2009, 66: 185-190. PMID: 19249750, PMCID: PMC2863311, DOI: 10.1016/j.biopsych.2009.01.029.Peer-Reviewed Original ResearchConceptsHeavy drinking smokersSelf-administration periodAlcohol consumptionPartial nicotinic agonistPlacebo-controlled investigationEffects of vareniclineReduced ethanol intakeAlcohol Self-AdministrationAlcohol use disorderNicotinic acetylcholine receptorsMedication pretreatmentAdverse eventsNumber of drinksPreclinical evidenceAdditional drinkEthanol intakeTobacco dependenceDaily smokersPriming doseVareniclineComorbid disordersNicotinic agonistsUse disordersPriming drinkPotential treatment
2008
Molecular Mechanisms Underlying the Motivational Effects of Nicotine
Brunzell DH, Picciotto MR. Molecular Mechanisms Underlying the Motivational Effects of Nicotine. Nebraska Symposium On Motivation 2008, 55: 17-30. PMID: 19013937, PMCID: PMC3594851, DOI: 10.1007/978-0-387-78748-0_3.Peer-Reviewed Original Research
2007
Prenatal and Adolescent Exposure to Tobacco Smoke Modulates the Development of White Matter Microstructure
Jacobsen LK, Picciotto MR, Heath CJ, Frost SJ, Tsou KA, Dwan RA, Jackowski MP, Constable RT, Mencl WE. Prenatal and Adolescent Exposure to Tobacco Smoke Modulates the Development of White Matter Microstructure. Journal Of Neuroscience 2007, 27: 13491-13498. PMID: 18057207, PMCID: PMC6673092, DOI: 10.1523/jneurosci.2402-07.2007.Peer-Reviewed Original ResearchConceptsAuditory processingAdolescent exposureWhite matter microstructureAuditory attention taskSymptoms of inattentionAuditory processing deficitsNicotine-induced disruptionAuditory attentionAttention taskPrenatal exposureProcessing deficitsAuditory signalsAdolescent smokersAdolescent smokingTobacco smokeFractional anisotropyDiffusion tensor anisotropyMaternal smokingCorticofugal fibersInternal capsuleParent educationDevelopmental disruptionReaction timeInternal capsule fibersAnatomical magnetic resonance images
2006
Smoking as a complex but critical covariate in neurobiological studies of posttraumatic stress disorders: a review
Rasmusson AM, Picciotto MR, Krishnan-Sarin S. Smoking as a complex but critical covariate in neurobiological studies of posttraumatic stress disorders: a review. Journal Of Psychopharmacology 2006, 20: 693-707. PMID: 16401662, DOI: 10.1177/0269881106060193.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderMental health disordersTobacco dependenceSmoking statusHealth disordersStress disorderMental health care providersHealth care providersNovel treatment interventionsClinical research studiesEffective clinical researchPublic health officialsNeurobiological mediatorsPathogenetic mechanismsSmoking ratesTranslational neuroscience perspectiveCare providersConcerned family membersEpidemiological studiesGeneral populationPsychiatric disordersTreatment interventionsClinical researchCritical covariatesHealth officialsHuman Tobacco Smokers in Early Abstinence Have Higher Levels of β2* Nicotinic Acetylcholine Receptors than Nonsmokers
Staley JK, Krishnan-Sarin S, Cosgrove KP, Krantzler E, Frohlich E, Perry E, Dubin JA, Estok K, Brenner E, Baldwin RM, Tamagnan GD, Seibyl JP, Jatlow P, Picciotto MR, London ED, O'Malley S, van Dyck CH. Human Tobacco Smokers in Early Abstinence Have Higher Levels of β2* Nicotinic Acetylcholine Receptors than Nonsmokers. Journal Of Neuroscience 2006, 26: 8707-8714. PMID: 16928859, PMCID: PMC6674379, DOI: 10.1523/jneurosci.0546-06.2006.Peer-Reviewed Original ResearchConceptsNAChR availabilityNicotinic acetylcholine receptorsEarly abstinenceAbstinent smokersHuman smokersAcetylcholine receptorsExpired carbon monoxide levelsAbility of smokersHuman tobacco smokersProperties of nicotineSingle photon emissionIA-85380Agonist radiotracerUrinary cotinineTobacco smokingTobacco smokersCerebral cortexLast cigaretteNicotine withdrawalWithdrawal symptomsPrevalent subtypeTobacco smokeAddictive chemicalNicotine dependenceSmokers
2003
Nicotine as a modulator of behavior: beyond the inverted U
Picciotto MR. Nicotine as a modulator of behavior: beyond the inverted U. Trends In Pharmacological Sciences 2003, 24: 493-499. PMID: 12967775, DOI: 10.1016/s0165-6147(03)00230-x.Peer-Reviewed Original ResearchConceptsNeuronal pathwaysEffects of nicotineNicotinic acetylcholine receptorsNeurotransmitter release studiesSmoking cessationNicotine reinforcementOccasional smokingKnockout mouse studiesSmoking behaviorAnimal studiesAcetylcholine receptorsDifferent subtypesMouse studiesBehavioral effectsNew interventionsNicotineElectrophysiological experimentsActivation stateRecent dataBehavioral responsesModulator of behaviorSmokingPathwaySubtypesReceptors
2002
Nicotinic receptors in aging and dementia
Picciotto MR, Zoli M. Nicotinic receptors in aging and dementia. Developmental Neurobiology 2002, 53: 641-655. PMID: 12436427, DOI: 10.1002/neu.10102.Peer-Reviewed Original ResearchConceptsNicotinic agonistsCognitive functionNeuronal nicotinic acetylcholine receptorsDevelopment of dementiaNicotinic acetylcholine receptorsCholinergic markersCholinergic functionNeuronal degenerationNicotinic receptorsEpidemiological studiesNicotinic functionAnimal studiesNeurodegenerative illnessesAcetylcholine receptorsCognitive deficitsDementiaNeurodegenerative diseasesImpaired subjectsDistinct actionsPatientsAgonistsDiseaseNicotineReceptorsSmoking