2012
Imaging Changes in Synaptic Acetylcholine Availability in Living Human Subjects
Esterlis I, Hannestad JO, Bois F, Sewell RA, Tyndale RF, Seibyl JP, Picciotto MR, Laruelle M, Carson RE, Cosgrove KP. Imaging Changes in Synaptic Acetylcholine Availability in Living Human Subjects. Journal Of Nuclear Medicine 2012, 54: 78-82. PMID: 23160789, PMCID: PMC3703589, DOI: 10.2967/jnumed.112.111922.Peer-Reviewed Original ResearchConceptsNicotinic acetylcholine receptor availabilityEndogenous neurotransmitter acetylcholineNicotinic acetylcholine receptorsPhysostigmine administrationAcetylcholine availabilityExtracellular acetylcholineBaseline scanHealthy subjectsReceptor availabilityExtracellular levelsAcetylcholine receptorsMolecular neuroimagingSPECT studiesAcetylcholineNonhuman primatesTissue concentrationsNeurotransmitter acetylcholineHuman subjectsSignificant reductionAdditional scansScansParent concentrationsSubjectsVivo estimationIA
2011
The Galanin Receptor 1 Gene Associates with Tobacco Craving in Smokers Seeking Cessation Treatment
Lori A, Tang Y, O'Malley S, Picciotto MR, Wu R, Conneely KN, Cubells JF. The Galanin Receptor 1 Gene Associates with Tobacco Craving in Smokers Seeking Cessation Treatment. Neuropsychopharmacology 2011, 36: 1412-1420. PMID: 21430647, PMCID: PMC3096810, DOI: 10.1038/npp.2011.25.Peer-Reviewed Original ResearchMeSH KeywordsAdultComputational BiologyFemaleGenome-Wide Association StudyGenotypeHumansLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single NucleotidePsychiatric Status Rating ScalesPsychological TestsReceptor, Galanin, Type 1Severity of Illness IndexSmoking CessationSurveys and QuestionnairesTobacco Use DisorderConceptsNicotine dependenceSingle nucleotide polymorphismsUseful therapeutic targetAddiction-related behaviorsFagerström scalePreclinical evidenceCessation treatmentPharmacological treatmentCessation trialCC subjectsTobacco cravingWithdrawal ScaleFTND scoreTC genotypeTherapeutic targetGalaninGene associatesSmokersSmokingBehavioral parametersSeverityGenetic association studiesSubjectsTreatmentScores