2016
CHRNA4 and ANKK1 Polymorphisms Influence Smoking-Induced Nicotinic Acetylcholine Receptor Upregulation
Esterlis I, Hillmer AT, Bois F, Pittman B, McGovern E, O’Malley S, Picciotto MR, Yang BZ, Gelernter J, Cosgrove KP. CHRNA4 and ANKK1 Polymorphisms Influence Smoking-Induced Nicotinic Acetylcholine Receptor Upregulation. Nicotine & Tobacco Research 2016, 18: 1845-1852. PMID: 27611310, PMCID: PMC4978979, DOI: 10.1093/ntr/ntw081.Peer-Reviewed Original ResearchMeSH KeywordsAdultCase-Control StudiesCorpus StriatumFemaleHumansIodine RadioisotopesMalePolymorphism, Single NucleotideProtein Serine-Threonine KinasesReceptors, NicotinicSmokingSmoking CessationSmoking PreventionTobacco Use DisorderTomography, Emission-Computed, Single-PhotonUp-RegulationWhite PeopleConceptsSmoking-induced changesWeeks of abstinenceNAChR availabilitySmoking cessationNicotine dependenceSex-matched nonsmokersTomography brain scanSingle nucleotide polymorphismsNicotinic acetylcholine receptorsSingle photon emissionDays of abstinenceNonsmoker levelsTobacco smokingReceptor upregulationBlood samplesAcetylcholine receptorsBrain scansCHRNA4 variantsCortical regionsSmokersCarrier statusExtended abstinenceAbstinencePersonalized programsNonsmokers
2011
The Galanin Receptor 1 Gene Associates with Tobacco Craving in Smokers Seeking Cessation Treatment
Lori A, Tang Y, O'Malley S, Picciotto MR, Wu R, Conneely KN, Cubells JF. The Galanin Receptor 1 Gene Associates with Tobacco Craving in Smokers Seeking Cessation Treatment. Neuropsychopharmacology 2011, 36: 1412-1420. PMID: 21430647, PMCID: PMC3096810, DOI: 10.1038/npp.2011.25.Peer-Reviewed Original ResearchMeSH KeywordsAdultComputational BiologyFemaleGenome-Wide Association StudyGenotypeHumansLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single NucleotidePsychiatric Status Rating ScalesPsychological TestsReceptor, Galanin, Type 1Severity of Illness IndexSmoking CessationSurveys and QuestionnairesTobacco Use DisorderConceptsNicotine dependenceSingle nucleotide polymorphismsUseful therapeutic targetAddiction-related behaviorsFagerström scalePreclinical evidenceCessation treatmentPharmacological treatmentCessation trialCC subjectsTobacco cravingWithdrawal ScaleFTND scoreTC genotypeTherapeutic targetGalaninGene associatesSmokersSmokingBehavioral parametersSeverityGenetic association studiesSubjectsTreatmentScores