2022
Nicotine Pharmacology, Abuse, and Addiction
Miller M, Picciotto M. Nicotine Pharmacology, Abuse, and Addiction. 2022, 4083-4101. DOI: 10.1007/978-3-030-88832-9_157.ChaptersTobacco useDrugs of abuseNeuropsychiatric disordersGreat public health relevanceGreat public health concernMesolimbic dopamine systemPre-clinical studiesPublic health concernPublic health relevanceNicotinic acetylcholine receptorsIonotropic neurotransmitter receptorsPrimary psychoactive componentSubstantial health risksNicotine exposureNicotine actsSustained tobacco useNicotine pharmacologyRewarding effectsNicotine addictionDopamine systemNervous systemNeurotransmitter receptorsNicotine useAcetylcholine receptorsAddictive properties
2019
Regulation of aggressive behaviors by nicotinic acetylcholine receptors: Animal models, human genetics, and clinical studies
Lewis AS, Picciotto MR. Regulation of aggressive behaviors by nicotinic acetylcholine receptors: Animal models, human genetics, and clinical studies. Neuropharmacology 2019, 167: 107929. PMID: 32058178, PMCID: PMC7080580, DOI: 10.1016/j.neuropharm.2019.107929.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNicotinic acetylcholine receptorsClinical studiesAnimal modelsAcetylcholine receptorsNeuropsychiatric disordersAggressive behaviorEffects of nAChRsAlpha 7 nAChRsSignificant side effectsHuman laboratory studiesLigand-gated ion channelsPsychopharmacological treatmentSide effectsMultiple key questionsHuman patientsNicotine NeuropharmacologyPredatory aggressionCHRNA7 geneHuman geneticsHuman genetic studiesPatientsNAChRsSevere aggressionIon channelsReceptorsInduction of reversible bidirectional social approach bias by olfactory conditioning in male mice
Chan J, Stout D, Pittenger ST, Picciotto MR, Lewis AS. Induction of reversible bidirectional social approach bias by olfactory conditioning in male mice. Social Neuroscience 2019, 15: 25-35. PMID: 31303111, PMCID: PMC6980898, DOI: 10.1080/17470919.2019.1644370.Peer-Reviewed Original ResearchConceptsPositive social experiencesSocial avoidanceSocial experienceNegative social experiencesBrief social defeatApproach biasNeural representationApproach behaviorExperience valenceBehavioral paradigmsBehavioral confoundsMost paradigmsNegative conditioningOlfactory conditioningSocial approachSocial defeatBrain regionsSubstantial functional impairmentAvoidanceConditioningParadigmNeuropsychiatric disordersFunctional impairmentExperienceConfounds
2016
Nicotine Pharmacology, Abuse, and Addiction
Miller M, Picciotto M. Nicotine Pharmacology, Abuse, and Addiction. 2016, 3659-3677. DOI: 10.1007/978-1-4939-3474-4_157.ChaptersTobacco useDrugs of abuseNeuropsychiatric disordersGreat public health relevanceGreat public health concernMesolimbic dopamine systemPre-clinical studiesPublic health concernPublic health relevanceNicotinic acetylcholine receptorsIonotropic neurotransmitter receptorsPrimary psychoactive componentSubstantial health risksNicotine exposureNicotine actsSustained tobacco useNicotine pharmacologyRewarding effectsNicotine addictionDopamine systemNervous systemNeurotransmitter receptorsNicotine useAcetylcholine receptorsAddictive properties
2015
Nicotine Pharmacology, Abuse, and Addiction
Miller M, Picciotto M. Nicotine Pharmacology, Abuse, and Addiction. 2015, 1-19. DOI: 10.1007/978-1-4614-6434-1_157-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsTobacco useDrugs of abuseNeuropsychiatric disordersGreat public health relevanceGreat public health concernMesolimbic dopamine systemPre-clinical studiesPublic health concernPublic health relevanceNicotinic acetylcholine receptorsIonotropic neurotransmitter receptorsPrimary psychoactive componentSubstantial health risksNicotine exposureNicotine actsSustained tobacco useNicotine pharmacologyRewarding effectsNicotine addictionDopamine systemNervous systemNeurotransmitter receptorsNicotine useAcetylcholine receptorsAddictive properties