2017
Maternal smoking and autism spectrum disorder: meta-analysis with population smoking metrics as moderators
Jung Y, Lee AM, McKee SA, Picciotto MR. Maternal smoking and autism spectrum disorder: meta-analysis with population smoking metrics as moderators. Scientific Reports 2017, 7: 4315. PMID: 28659613, PMCID: PMC5489536, DOI: 10.1038/s41598-017-04413-1.Peer-Reviewed Original ResearchConceptsMale smoking prevalenceMaternal smokingNicotine exposureSmoking prevalenceAdult male smoking prevalenceSignificant associationPostnatal nicotine exposureUtero nicotine exposureAutism spectrum disorderRandom-effects modelWorld Health Organization dataMeta-regression analysisSmoking metricsSmoke exposureSecondhand smokingPooled ORsObservational studySpectrum disorderSmokingBrain developmentControl participantsPrevalenceASD riskExposureAssociation
2008
Nicotine-induced plasticity during development: Modulation of the cholinergic system and long-term consequences for circuits involved in attention and sensory processing
Heath CJ, Picciotto MR. Nicotine-induced plasticity during development: Modulation of the cholinergic system and long-term consequences for circuits involved in attention and sensory processing. Neuropharmacology 2008, 56: 254-262. PMID: 18692078, PMCID: PMC2635334, DOI: 10.1016/j.neuropharm.2008.07.020.Peer-Reviewed Original ResearchConceptsDevelopmental nicotine exposureSmoke exposureNicotine exposureEndogenous cholinergic signalingTobacco smoke exposureSensory processingSensory processing deficitsNicotinic acetylcholine receptorsAttention deficit hyperactivity disorderCritical periodDeficit hyperactivity disorderPregnant womenCholinergic systemCholinergic signalingLong-term consequencesEpidemiological studiesAnimal modelsAcetylcholine receptorsSynaptic plasticityNeuropsychiatric conditionsHyperactivity disorderNicotineExposureProcessing deficitsBehavioral processes
2006
Guidelines on nicotine dose selection for in vivo research
Matta SG, Balfour DJ, Benowitz NL, Boyd RT, Buccafusco JJ, Caggiula AR, Craig CR, Collins AC, Damaj MI, Donny EC, Gardiner PS, Grady SR, Heberlein U, Leonard SS, Levin ED, Lukas RJ, Markou A, Marks MJ, McCallum SE, Parameswaran N, Perkins KA, Picciotto MR, Quik M, Rose JE, Rothenfluh A, Schafer WR, Stolerman IP, Tyndale RF, Wehner JM, Zirger JM. Guidelines on nicotine dose selection for in vivo research. Psychopharmacology 2006, 190: 269-319. PMID: 16896961, DOI: 10.1007/s00213-006-0441-0.Peer-Reviewed Original ResearchConceptsRoute of administrationDose selectionAnimal modelsDose rangeNicotine replacement therapyChronic nicotine exposureDose-response relationshipDrug-taking behaviorTobacco exposureNicotine exposureCigarette smokingReplacement therapyVivo effectsChronic exposureNicotine metabolismVivo responseNonhuman primatesVivo studiesObjectivesThis reviewRegimenVivo researchAdministrationExposureGenetic backgroundReview
2005
β2-Subunit-containing nicotinic acetylcholine receptors are involved in nicotine-induced increases in conditioned reinforcement but not progressive ratio responding for food in C57BL/6 mice
Brunzell DH, Chang JR, Schneider B, Olausson P, Taylor JR, Picciotto MR. β2-Subunit-containing nicotinic acetylcholine receptors are involved in nicotine-induced increases in conditioned reinforcement but not progressive ratio responding for food in C57BL/6 mice. Psychopharmacology 2005, 184: 328-338. PMID: 16133126, DOI: 10.1007/s00213-005-0099-z.Peer-Reviewed Original ResearchConceptsNicotine exposureNicotinic acetylcholine receptorsFood-reinforced respondingAcetylcholine receptorsPrior nicotine exposureNicotine-induced increasesProgressive ratioNicotinic receptor subtypesEffects of nicotineWild-type miceProgressive ratio testC57BL/6 miceReceptor subtypesConclusionThese dataChronic exposureReinforcement testingMiceΒ2 subunitUnpaired presentationsExposureReceptorsApproach trainingPresentationPaired presentationsPrimary reinforcement
1999
Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine
Kelz M, Chen J, Carlezon W, Whisler K, Gilden L, Beckmann A, Steffen C, Zhang Y, Marotti L, Self D, Tkatch T, Baranauskas G, Surmeier D, Neve R, Duman R, Picciotto M, Nestler E. Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine. Nature 1999, 401: 272-276. PMID: 10499584, DOI: 10.1038/45790.Peer-Reviewed Original ResearchConceptsNucleus accumbensGlutamate receptor subunit GluR2Locomotor-activating effectsFos family transcription factorsTranscription factor ΔFosBDrugs of abuseΔFosB expressionAcute exposureTransgenic miceChronic exposureSubunit GluR2ΔFosBCocaine addictionAccumbensCocainePersistent expressionTranscription factorsSustained accumulationBrainExposureStable isoformSubset of nucleiExpressionGene expressionMorphine