2019
The role of acetylcholine in negative encoding bias: Too much of a good thing?
Mineur YS, Picciotto MR. The role of acetylcholine in negative encoding bias: Too much of a good thing? European Journal Of Neuroscience 2019, 53: 114-125. PMID: 31821620, PMCID: PMC7282966, DOI: 10.1111/ejn.14641.Peer-Reviewed Original ResearchConceptsPotential neural pathwaysSymptoms of anxietyAffective processesSustained attentionStressful eventsCore symptomsFacilitate learningAppropriate learningNeural pathwaysRole of acetylcholineGood thingLevels of AChLearningDepressionBiasDepressive episodeNeuromodulatory roleCholinergic signalingAnimal studiesAnxietyMemoryAcetylcholine SignalingHigh levelsEncodingACh
2015
Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder
Van Schalkwyk GI, Lewis AS, Qayyum Z, Koslosky K, Picciotto MR, Volkmar FR. Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2015, 45: 3061-3066. PMID: 25982311, PMCID: PMC4755349, DOI: 10.1007/s10803-015-2471-0.Peer-Reviewed Original ResearchConceptsTransdermal nicotineNicotine administrationAutism spectrum disorderTransdermal nicotine administrationAdjunctive medicationsCurrent pharmacotherapyNicotine patchCholinergic dysfunctionEmergency medicationPreclinical studiesSpectrum disorderAnimal studiesAcetylcholinergic neurotransmissionNeuropsychiatric conditionsAggressive episodesMajor causeNicotineASD pathophysiologyMedicationsMorbidityFurther studiesAggression-related behaviorsAdministrationDisordersAdolescents
2007
Genetics of nicotinic acetylcholine receptors: Relevance to nicotine addiction
Mineur YS, Picciotto MR. Genetics of nicotinic acetylcholine receptors: Relevance to nicotine addiction. Biochemical Pharmacology 2007, 75: 323-333. PMID: 17632086, PMCID: PMC2212607, DOI: 10.1016/j.bcp.2007.06.010.Peer-Reviewed Original ResearchConceptsGene productsNicotinic acetylcholine receptorsClassical genetic approachesClasses of genesNicotine dependenceGenetic engineering studiesNumber of genesGenetic engineering techniquesNicotine addictionAnimal studiesAcetylcholine receptorsGene association studiesHuman twin studiesNumber of subunitsSubstantial genetic componentGenetic approachesGenetic basisDopaminergic cell bodiesAbility of nicotineVentral tegmental areaAssociation studiesLines of evidenceGenetic componentNicotine-related behaviorsMesolimbic system
2003
Nicotine as a modulator of behavior: beyond the inverted U
Picciotto MR. Nicotine as a modulator of behavior: beyond the inverted U. Trends In Pharmacological Sciences 2003, 24: 493-499. PMID: 12967775, DOI: 10.1016/s0165-6147(03)00230-x.Peer-Reviewed Original ResearchConceptsNeuronal pathwaysEffects of nicotineNicotinic acetylcholine receptorsNeurotransmitter release studiesSmoking cessationNicotine reinforcementOccasional smokingKnockout mouse studiesSmoking behaviorAnimal studiesAcetylcholine receptorsDifferent subtypesMouse studiesBehavioral effectsNew interventionsNicotineElectrophysiological experimentsActivation stateRecent dataBehavioral responsesModulator of behaviorSmokingPathwaySubtypesReceptors
2002
Nicotinic receptors in aging and dementia
Picciotto MR, Zoli M. Nicotinic receptors in aging and dementia. Developmental Neurobiology 2002, 53: 641-655. PMID: 12436427, DOI: 10.1002/neu.10102.Peer-Reviewed Original ResearchConceptsNicotinic agonistsCognitive functionNeuronal nicotinic acetylcholine receptorsDevelopment of dementiaNicotinic acetylcholine receptorsCholinergic markersCholinergic functionNeuronal degenerationNicotinic receptorsEpidemiological studiesNicotinic functionAnimal studiesNeurodegenerative illnessesAcetylcholine receptorsCognitive deficitsDementiaNeurodegenerative diseasesImpaired subjectsDistinct actionsPatientsAgonistsDiseaseNicotineReceptorsSmokingEffect of nicotine and nicotinic receptors on anxiety and depression
Picciotto MR, Brunzell DH, Caldarone BJ. Effect of nicotine and nicotinic receptors on anxiety and depression. Neuroreport 2002, 13: 1097-1106. PMID: 12151749, DOI: 10.1097/00001756-200207020-00006.Peer-Reviewed Original ResearchConceptsNicotine treatmentActivation of nAChRsDorsal raphe nucleusEffects of nicotineMesolimbic dopamine systemNicotinic acetylcholine receptorsNicotine administrationMonoaminergic transmissionChronic useRaphe nucleusAnxiolytic actionLateral septumNicotinic receptorsClassical neurotransmittersNormal brainAnimal studiesDopamine systemBrain areasAcetylcholine receptorsNicotineEnsemble of studiesNAChRsAnxiety modelsAdministration studiesDepression
2000
Nicotinic Receptors in the Brain: Links between Molecular Biology and Behavior
Picciotto M, Caldarone B, King S, Zachariou V. Nicotinic Receptors in the Brain: Links between Molecular Biology and Behavior. Neuropsychopharmacology 2000, 22: 451-465. PMID: 10731620, DOI: 10.1016/s0893-133x(99)00146-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNicotinic receptorsIndividual subunitsNicotinic receptor subtypesNicotinic receptor agonistsMolecular biologyNicotinic acetylcholine receptorsAcetylcholine receptor subunitsPain sensitivityReceptor agonistReceptor subtypesAnimal studiesNicotinic subunitsAcetylcholine receptorsAddictive propertiesMolecular cloningMolecular dataReceptor subunitsBehavioral effectsNicotineSubunit combinationsReceptorsNative receptorSubunitsSubunit compositionSubsequent studies