2015
Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder
Van Schalkwyk GI, Lewis AS, Qayyum Z, Koslosky K, Picciotto MR, Volkmar FR. Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2015, 45: 3061-3066. PMID: 25982311, PMCID: PMC4755349, DOI: 10.1007/s10803-015-2471-0.Peer-Reviewed Original ResearchConceptsTransdermal nicotineNicotine administrationAutism spectrum disorderTransdermal nicotine administrationAdjunctive medicationsCurrent pharmacotherapyNicotine patchCholinergic dysfunctionEmergency medicationPreclinical studiesSpectrum disorderAnimal studiesAcetylcholinergic neurotransmissionNeuropsychiatric conditionsAggressive episodesMajor causeNicotineASD pathophysiologyMedicationsMorbidityFurther studiesAggression-related behaviorsAdministrationDisordersAdolescents
2008
Allelic Variation of Calsyntenin 2 (CLSTN2) Modulates the Impact of Developmental Tobacco Smoke Exposure on Mnemonic Processing in Adolescents
Jacobsen LK, Picciotto MR, Heath CJ, Mencl WE, Gelernter J. Allelic Variation of Calsyntenin 2 (CLSTN2) Modulates the Impact of Developmental Tobacco Smoke Exposure on Mnemonic Processing in Adolescents. Biological Psychiatry 2008, 65: 671-679. PMID: 19058786, PMCID: PMC2864130, DOI: 10.1016/j.biopsych.2008.10.024.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdolescent BehaviorAdolescent DevelopmentAllelic ImbalanceBrainCalcium-Binding ProteinsFemaleGenotypeHumansIntracellular Signaling Peptides and ProteinsMaleMembrane ProteinsMemory DisordersPhosphoproteinsPregnancyPrenatal Exposure Delayed EffectsProteinsTemporal LobeTobacco Smoke PollutionConceptsAdolescent exposureCalsyntenin-2Visuospatial memoryMedial temporal lobe functionRecall of wordsRecognition memory taskFunctional magnetic resonance imaging (fMRI) dataTemporal lobe functionEnhanced functional connectivityMemory taskVerbal recallMnemonic processingVerbal recognitionIndividual differencesAdolescent developmentLobe functionKIBRA genotypeDependent measuresMagnetic resonance imaging dataFunctional connectivityParahippocampal gyrusSubsequent deficitsBrain regionsMemoryAdolescents