2020
PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies
Bhatt S, Hillmer AT, Girgenti MJ, Rusowicz A, Kapinos M, Nabulsi N, Huang Y, Matuskey D, Angarita GA, Esterlis I, Davis MT, Southwick SM, Friedman MJ, Duman R, Carson R, Krystal J, Pietrzak R, Cosgrove K. PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies. Nature Communications 2020, 11: 2360. PMID: 32398677, PMCID: PMC7217830, DOI: 10.1038/s41467-020-15930-5.Peer-Reviewed Original ResearchMeSH KeywordsAcetamidesAdaptor Proteins, Signal TransducingAdultBrainCase-Control StudiesFemaleGene Expression ProfilingHealthy VolunteersHumansMaleMicrogliaMiddle AgedPositron-Emission TomographyPyridinesRadiopharmaceuticalsReceptors, GABAReceptors, Tumor Necrosis Factor, Member 14Sex FactorsStress Disorders, Post-TraumaticYoung AdultConceptsPosttraumatic stress disorderPeripheral immune activationImmune activationHigher C-reactive protein levelsC-reactive protein levelsTSPO availabilityTranslocator proteinBrain microglial activationTomography brain imagingStress-related pathophysiologyPositron emission tomography (PET) brain imagingNeuroimmune activationMicroglial activationPTSD symptom severityImmunologic regulationPostmortem studiesPTSD subgroupHealthy individualsSymptom severityTrauma exposurePTSD groupStress disorderLower relative expressionBrain imagingPET imaging
2019
Measuring the effects of ketamine on mGluR5 using [18F]FPEB and PET
Holmes SE, Gallezot JD, Davis MT, DellaGioia N, Matuskey D, Nabulsi N, Krystal JH, Javitch JA, DeLorenzo C, Carson RE, Esterlis I. Measuring the effects of ketamine on mGluR5 using [18F]FPEB and PET. Cerebrovascular And Brain Metabolism Reviews 2019, 40: 2254-2264. PMID: 31744389, PMCID: PMC7585925, DOI: 10.1177/0271678x19886316.Peer-Reviewed Original ResearchConceptsEffects of ketamineKetamine infusionGlutamate transmissionMetabotropic glutamate receptor 5Ketamine-induced effectsKetamine-induced changesGlutamate receptor 5Promising treatment targetDrug challenge studiesTwo-tissue compartment modelMGluR5 radioligandBlood pressureMGluR5 availabilityBaseline scanOutcome measuresHealthy subjectsHeart ratePsychiatric disordersReceptor 5Modulatory effectsMGluR5Treatment targetsChallenge studiesArterial input functionChallenge paradigmA factor analytic evaluation of the World Health Organization Disability Assessment Schedule 2.0 among veterans presenting to a generalist mental health clinic
Sexton MB, Davis MT, Lusk RK, Lyubkin M, Chermack ST. A factor analytic evaluation of the World Health Organization Disability Assessment Schedule 2.0 among veterans presenting to a generalist mental health clinic. Psychiatry Research 2019, 272: 638-642. PMID: 30616134, DOI: 10.1016/j.psychres.2019.01.008.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmbulatory Care FacilitiesDiagnostic and Statistical Manual of Mental DisordersDisability EvaluationDisabled PersonsFactor Analysis, StatisticalFemaleHumansMaleMental HealthMental Health ServicesMiddle AgedSurveys and QuestionnairesUnited StatesVeteransWorld Health OrganizationYoung AdultConceptsWorld Health Organization Disability Assessment Schedule 2.0Disability Assessment Schedule 2.0WHODAS 2.0Veterans AffairsMental health clinicsU.S. veteran populationClinical decision makingVeterans Benefits AdministrationHealth clinicsVeteran populationMental disordersMental healthcareGlobal assessmentStatistical ManualFactor analytic evaluationVeteran sampleDSM-5Multiaxial systemVeteransFactor structureNon-clinical sampleFifth editionExploratory analysisGood model fitDiscontinuation
2016
Demonstration and validation of a new pressure-based MRI-safe pain tolerance device
Davis MT, Daniel TA, Witte TK, Beyers RJ, Willis JZ, Wang Y, Denney TS, Katz JS, Salibi N, Deshpande G. Demonstration and validation of a new pressure-based MRI-safe pain tolerance device. Journal Of Neuroscience Methods 2016, 271: 160-168. PMID: 27378028, DOI: 10.1016/j.jneumeth.2016.07.001.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingPain toleranceAnterior cingulate gyrusPressure-related painMagnetic resonance imagingElicit painPain applicationCingulate gyrusPainT MRI scannerMRI environmentResonance imagingAlgometerAvailable algometerBOLD activationBrain activationValid instrumentMRI scannerPresent studyActivationIdentical procedureA Factor Analytic Evaluation of the Difficulties in Emotion Regulation Scale
Lee DJ, Witte TK, Bardeen JR, Davis MT, Weathers FW. A Factor Analytic Evaluation of the Difficulties in Emotion Regulation Scale. Journal Of Clinical Psychology 2016, 72: 933-946. PMID: 27018649, DOI: 10.1002/jclp.22297.Peer-Reviewed Original Research
2015
The Posttraumatic Stress Disorder Checklist for DSM‐5 (PCL‐5): Development and Initial Psychometric Evaluation
Blevins CA, Weathers FW, Davis MT, Witte TK, Domino JL. The Posttraumatic Stress Disorder Checklist for DSM‐5 (PCL‐5): Development and Initial Psychometric Evaluation. Journal Of Traumatic Stress 2015, 28: 489-498. PMID: 26606250, DOI: 10.1002/jts.22059.Peer-Reviewed Original ResearchConceptsPosttraumatic Stress Disorder ChecklistPCL-5 scoresComparative fit indexPCL-5Initial psychometric evaluationPTSD symptomsTucker-Lewis indexDSM-5Trauma-exposed college studentsSelf-report measuresPsychometric evaluationStrong internal consistencyConfirmatory factor analysisDSM-5 changesTest-retest reliabilityPTSD criteriaStudy 1Study 2Sound measureDiscriminant validityPsychometric propertiesCollege studentsFit indicesAdequate fitSuperior fit
2014
PTSD Symptom Clusters Are Differentially Associated with Components of the Acquired Capability for Suicide
Zuromski KL, Davis MT, Witte TK, Weathers F, Blevins C. PTSD Symptom Clusters Are Differentially Associated with Components of the Acquired Capability for Suicide. Suicide And Life-Threatening Behavior 2014, 44: 682-697. PMID: 24796870, DOI: 10.1111/sltb.12098.Peer-Reviewed Original ResearchConceptsPTSD symptom clustersPosttraumatic stress disorderAcquired CapabilitySpecific PTSD symptom clustersSymptom clustersTrauma-exposed undergraduatesInterpersonal-psychological theorySuicidal behaviorAnxious arousalPTSD symptomsStress disorderPain tolerancePrevious researchCurrent studySuicideNumbingObserved relationshipArousalRelationshipUndergraduatesConstructsBehaviorDisordersResearchSymptoms
2012
Long-Acting Methylphenidate Reduces Collision Rates of Young Adult Drivers With Attention-Deficit/Hyperactivity Disorder
Cox DJ, Davis M, Mikami AY, Singh H, Merkel RL, Burket R. Long-Acting Methylphenidate Reduces Collision Rates of Young Adult Drivers With Attention-Deficit/Hyperactivity Disorder. Journal Of Clinical Psychopharmacology 2012, 32: 225-230. PMID: 22367664, DOI: 10.1097/jcp.0b013e3182496dc5.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdolescentAttention Deficit Disorder with HyperactivityAutomobile DrivingCentral Nervous System StimulantsCross-Over StudiesDelayed-Action PreparationsFemaleHumansMaleMethylphenidatePsychiatric Status Rating ScalesPsychometricsRisk-TakingTreatment OutcomeVideo RecordingYoung AdultConceptsAttention-deficit/hyperactivity disorderBlood pressureMedication conditionADHD medicationHeart rateBody weightYoung adultsHyperactivity disorderSignificant skin reactionsTotal ADHDMinimal adverse effectsConners' Adult ADHD Rating ScaleSignificant comorbiditiesYoung adult driversADHD Rating ScaleSkin reactionsAdult ADHD Rating ScaleInclusion criteriaAdult driversMTS patchesTransdermal systemRating ScaleAdverse effectsMethylphenidateADHD diagnosis