2013
Randomized clinical trial of disulfiram for cocaine dependence or abuse during buprenorphine treatment
Schottenfeld RS, Chawarski MC, Cubells JF, George TP, Lappalainen J, Kosten TR. Randomized clinical trial of disulfiram for cocaine dependence or abuse during buprenorphine treatment. Drug And Alcohol Dependence 2013, 136: 36-42. PMID: 24462581, DOI: 10.1016/j.drugalcdep.2013.12.007.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAlcohol DeterrentsAlcoholismAllelesBuprenorphineCocaine-Related DisordersData Interpretation, StatisticalDisulfiramDNADouble-Blind MethodDrug Therapy, CombinationFemaleGenotypeHumansMaleMiddle AgedNarcotic AntagonistsOpioid-Related DisordersPharmacogeneticsPolymerase Chain ReactionSample SizeTreatment OutcomeYoung AdultConceptsUrine testsCocaine useMechanism of actionCocaine dependenceClinical trialsWeeks abstinencePlacebo-controlled clinical trialEfficacy of disulfiramPharmacogenetics of responseDouble-blind treatmentBuprenorphine maintenance treatmentRandomized clinical trialsOpioid-dependent participantsT allele carriersFrequent cocaine useDopamine β-hydroxylaseBuprenorphine treatmentPrimary outcomeTreat comparisonMaintenance treatmentPharmacogenetic interactionsTreatment responseTT genotypeCocaine abstinenceConsecutive weeks
2006
Counseling plus Buprenorphine–Naloxone Maintenance Therapy for Opioid Dependence
Fiellin DA, Pantalon MV, Chawarski MC, Moore BA, Sullivan LE, O'Connor PG, Schottenfeld RS. Counseling plus Buprenorphine–Naloxone Maintenance Therapy for Opioid Dependence. New England Journal Of Medicine 2006, 355: 365-374. PMID: 16870915, DOI: 10.1056/nejmoa055255.Peer-Reviewed Original ResearchMeSH KeywordsAdultBuprenorphineCocaine-Related DisordersCombined Modality TherapyCounselingFemaleHumansMaleNaloxoneNarcotic AntagonistsOpioid-Related DisordersConceptsStandard medical managementBuprenorphine-naloxone treatmentIllicit opioid useMedical managementOpioid dependenceWeekly medicationOpioid useIllicit opioidsWeekly counselingPrimary careUrine specimensConsecutive weeksProportion of patientsImproved treatment outcomesMaintenance therapyPrimary outcomeClinical trialsMedication distributionSimilar efficacyTreatment outcomesMedicationsSelf-reported frequencyPatientsFrequency of attendanceMean percentage
2005
Methadone Versus Buprenorphine With Contingency Management or Performance Feedback for Cocaine and Opioid Dependence
Schottenfeld RS, Chawarski MC, Pakes JR, Pantalon MV, Carroll KM, Kosten TR. Methadone Versus Buprenorphine With Contingency Management or Performance Feedback for Cocaine and Opioid Dependence. American Journal Of Psychiatry 2005, 162: 340-349. PMID: 15677600, DOI: 10.1176/appi.ajp.162.2.340.Peer-Reviewed Original ResearchConceptsCo-occurring cocaineDrug-free testOpioid dependenceMaintenance treatmentContingency managementOpioid agonist maintenance treatmentAgonist maintenance treatmentDaily sublingual buprenorphineEffects of buprenorphinePrimary outcome measureMixed-model repeated-measures analysisDouble-blind designUrine test resultsNarcotic treatment programsVoucher valueRepeated-measures analysisSublingual buprenorphineTreatment guidelinesIllicit opioidsUrine testsTreatment outcomesOutcome measuresSustained abstinenceWeek 13Buprenorphine
2004
Linking Process and Outcome in the Community Reinforcement Approach for Treating Cocaine Dependence: A Preliminary Report
Pantalon MV, Chawarski MC, Falcioni J, Pakes J, Schottenfeld RS. Linking Process and Outcome in the Community Reinforcement Approach for Treating Cocaine Dependence: A Preliminary Report. The American Journal Of Drug And Alcohol Abuse 2004, 30: 353-367. PMID: 15230080, DOI: 10.1081/ada-120037382.Peer-Reviewed Original ResearchConceptsCommunity Reinforcement ApproachTherapy process variablesCocaine dependenceReinforcement approachPositive therapeutic allianceRating ScalePattern of interrelationshipsBig-picture goalsInterpersonal processesTherapist empathyInterpersonal dimensionsTherapeutic allianceCocaine abstinenceNew rating scaleHomework scoresUrine toxicology testsConsecutive weeks
2000
Disulfiram versus placebo for cocaine dependence in buprenorphine-maintained subjects: a preliminary trial
George T, Chawarski M, Pakes J, Carroll K, Kosten T, Schottenfeld R. Disulfiram versus placebo for cocaine dependence in buprenorphine-maintained subjects: a preliminary trial. Biological Psychiatry 2000, 47: 1080-1086. PMID: 10862808, DOI: 10.1016/s0006-3223(99)00310-8.Peer-Reviewed Original ResearchConceptsBuprenorphine-maintained subjectsCocaine dependenceUrine testsBuprenorphine-maintained patientsEffect of disulfiramContinuous cocaine abstinenceCocaine-dependent subjectsDrug use severityBuprenorphine maintenancePlacebo treatmentDisulfiram groupPlaceboCocaine abstinencePotential efficacyDependent subjectsBaseline measuresDisulfiramNumber of daysWeeksHigh rateSubjectsTrialsPreliminary trialTreatmentPreliminary studyThrice-weekly versus daily buprenorphine maintenance
Schottenfeld R, Pakes J, O’Connor P, Chawarski M, Oliveto A, Kosten T. Thrice-weekly versus daily buprenorphine maintenance. Biological Psychiatry 2000, 47: 1072-1079. PMID: 10862807, DOI: 10.1016/s0006-3223(99)00270-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultBuprenorphineCocaine-Related DisordersDouble-Blind MethodFemaleHeroin DependenceHumansMaleNarcotic AntagonistsOpioid-Related DisordersPsychiatric Status Rating ScalesConceptsSublingual buprenorphineMaintenance treatmentSelf-reported illicit drug useDrug useOpioid agonist maintenance treatmentOpioid-positive urine testsAgonist maintenance treatmentDaily clinic attendanceDaily sublingual buprenorphineThrice-weekly dosingOpioid-dependent patientsUrine toxicology testsSignificant differencesIllicit drug useSelf-reported numberBuprenorphine maintenanceClinic attendanceWeekly doseIllicit opioidsMedication complianceThrice weeklyUrine testsOutcome measuresBuprenorphineCounseling attendanceCommunity reinforcement approach for combined opioid and cocaine dependence Patterns of engagement in alternate activities
Schottenfeld R, Pantalon M, Chawarski M, Pakes J, M.Ed. Community reinforcement approach for combined opioid and cocaine dependence Patterns of engagement in alternate activities. Journal Of Substance Use And Addiction Treatment 2000, 18: 255-261. PMID: 10742639, DOI: 10.1016/s0740-5472(99)00062-8.Peer-Reviewed Original ResearchConceptsCommunity Reinforcement ApproachNondrug-related activitiesDrug useGroup drug counselingClinical trialsDrug counselingReinforcement approachCocaine dependenceCurrent trialOpioidsAbstinenceSignificant differencesPatientsTrialsAlternate activitiesAverage hoursEffective overallTotal numberHoursRecreational activitiesActivityWeeksCocaine