1999
Quantitative detection of Borrelia burgdorferi with a microtiter-based competitive polymerase chain reaction assay
Germer J, Ryckmann B, Moro M, Hofmeister E, Barthold S, Bockenstedt L, Persing D. Quantitative detection of Borrelia burgdorferi with a microtiter-based competitive polymerase chain reaction assay. Molecular Diagnosis 1999, 4: 185-193. PMID: 10553019, DOI: 10.1016/s1084-8592(99)80022-8.Peer-Reviewed Original ResearchConceptsLyme disease pathogenesisPolymerase chain reactionDisease pathogenesisBALB/c miceAvailable enzyme-linked immunosorbentB. burgdorferi flagellin geneChain reactionQuantitative competitive polymerase chain reactionEnzyme-linked immunosorbentCompetitive polymerase chain reactionImmunologic componentsInfectious burdenC miceInflammatory processC3H miceMurine modelAnimal modelsTissue weightTissue burdenLyme diseaseTarget tissuesSpecific target tissuesBorrelia burgdorferiDetection kitCompetitive internal standard
1997
Protective and Arthritis-Resolving Activity in Sera of Mice Infected with Borrelia burgdorferi
Barthold S, Feng S, Bockenstedt L, Fikrig E, Feen K. Protective and Arthritis-Resolving Activity in Sera of Mice Infected with Borrelia burgdorferi. Clinical Infectious Diseases 1997, 25: s9-s17. PMID: 9233658, DOI: 10.1086/516166.Peer-Reviewed Original ResearchConceptsImmune serumSyringe challengePassive protective activitySerum of miceArthritis resolutionHost-adapted spirochetesImmunocompetent miceJoint tissuesTissue transplantsProtective activityImmunodominant regionMiceSerumInfectionBorrelia burgdorferiB. burgdorferiRecombinant formBurgdorferiSpirochetesTissueChallenge inoculationCarditisTransplantSpirochetemiaAntigen