1999
Quantitative detection of Borrelia burgdorferi with a microtiter-based competitive polymerase chain reaction assay
Germer J, Ryckmann B, Moro M, Hofmeister E, Barthold S, Bockenstedt L, Persing D. Quantitative detection of Borrelia burgdorferi with a microtiter-based competitive polymerase chain reaction assay. Molecular Diagnosis 1999, 4: 185-193. PMID: 10553019, DOI: 10.1016/s1084-8592(99)80022-8.Peer-Reviewed Original ResearchConceptsLyme disease pathogenesisPolymerase chain reactionDisease pathogenesisBALB/c miceAvailable enzyme-linked immunosorbentB. burgdorferi flagellin geneChain reactionQuantitative competitive polymerase chain reactionEnzyme-linked immunosorbentCompetitive polymerase chain reactionImmunologic componentsInfectious burdenC miceInflammatory processC3H miceMurine modelAnimal modelsTissue weightTissue burdenLyme diseaseTarget tissuesSpecific target tissuesBorrelia burgdorferiDetection kitCompetitive internal standard
1997
Lyme Borreliosis in Transgenic Mice Tolerant to OspA from Borrelia burgdorferi 25015
Fikrig E, Barthold S, Chen M, Tao H, Ali-Salaam P, Bockenstedt L, Flavell R. Lyme Borreliosis in Transgenic Mice Tolerant to OspA from Borrelia burgdorferi 25015. The Journal Of Infectious Diseases 1997, 175: 1000-1003. PMID: 9086169, DOI: 10.1086/513958.Peer-Reviewed Original ResearchConceptsTransgenic miceLyme borreliosisC3H/HeN miceTolerance of miceSurface protein ABorrelia burgdorferi outer surface protein ASignificant arthritisOuter surface protein ALyme arthritisProtective immunityNontransgenic littermatesHeN miceOspA antibodiesDisease pathogenesisMiceArthritisB. burgdorferi N40OspABorreliosisCellular responsesProtein AResponseImmunizationPathogenesisLittermates