2024
Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study.
Ding E, Deng F, Fang J, Liu J, Yan W, Yao Q, Miao K, Wang Y, Sun P, Li C, Liu Y, Dong H, Dong L, Zhang X, Lu Y, Lin X, Ding C, Li T, Shi Y, Cai Y, Liu X, Godri Pollitt K, Ji J, Tong S, Tang S, Shi X. Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study. Environmental Health Perspectives 2024, 132: 97005. PMID: 39240788, PMCID: PMC11379127, DOI: 10.1289/ehp13864.Peer-Reviewed Original ResearchConceptsDyslipidemia markersCardiovascular diseaseMulti-omicsMarkers of dyslipidemiaExamination of cytokinesMeasurement of cytokinesSerum lipidomeSystemic inflammationMulti-omics profilingCardiac functionDyslipidemiaPrimary preventionClinical measuresSerumChinese adultsBlood transcriptomeImpact spectraCytokinesExposome-wide association studyInflammationMarkersBiomolecular pathwaysAssociationHealthy older adultsElectrocardiogram
2023
Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60–69 Years of Age: Evidence from the China BAPE Study
Ding E, Deng F, Fang J, Li T, Hou M, Liu J, Miao K, Yan W, Fang K, Shi W, Fu Y, Liu Y, Dong H, Dong L, Ding C, Liu X, Pollitt K, Ji J, Shi Y, Cai Y, Tang S, Shi X. Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60–69 Years of Age: Evidence from the China BAPE Study. Environmental Health Perspectives 2023, 131: 047009. PMID: 37042841, PMCID: PMC10094192, DOI: 10.1289/ehp11896.Peer-Reviewed Original ResearchConceptsYears of ageOPE exposureAdults 60OPE metabolitesCommon endocrine-disrupting chemicalsChina BAPE studySubsequent key eventsType 2 diabetesExposure reduction strategiesAdverse outcome pathwaysDiabetogenic effectInsulin resistanceUrine metabolomeElevated riskEster exposureParticipants 60Endocrine-disrupting chemicalsBlood transcriptomeAdverse effectsGlycometabolic disordersBiological etiologyAgeT2DMulti-omics analysisMarkers