2021
SBRT for the Treatment of Isolated Local Recurrence of Resected Pancreatic Cancer
Morris L, Viehman J, Baclay J, Chang D, Kerans S, Molitoris J, Regine W, Johung K, Jethwa K, Neibart S, Jabbour S, Hallemeier C. SBRT for the Treatment of Isolated Local Recurrence of Resected Pancreatic Cancer. International Journal Of Radiation Oncology • Biology • Physics 2021, 111: e61. DOI: 10.1016/j.ijrobp.2021.07.408.Peer-Reviewed Original ResearchStereotactic body radiation therapyPancreatic ductal adenocarcinomaSurgical resectionFirst recurrenceCumulative incidenceLocal recurrenceDistant metastasisCompletion of SBRTTime of SBRTLow treatment-related toxicityMulti-institutional retrospective analysisDetails of recurrenceGrade 3 toxicityPrior treatment characteristicsInitial surgical resectionR0 resection rateTreatment-related toxicityRisk of progressionIsolated local recurrenceOverall survival estimatesLocal tumor controlSuperior mesenteric arteryBody radiation therapyKaplan-Meier modelOncologic surgical resection
2020
A Single-Institution Experience of Induction 5-Fluorouracil, Leucovorin, Irinotecan, and Oxaliplatin Followed by Surgery Versus Consolidative Radiation for Borderline and Locally Advanced Unresectable Pancreatic Cancer.
Cecchini M, Miccio JA, Pahade J, Lacy J, Salem RR, Johnson SB, Blakaj A, Stein S, Kortmansky JS, Johung KL. A Single-Institution Experience of Induction 5-Fluorouracil, Leucovorin, Irinotecan, and Oxaliplatin Followed by Surgery Versus Consolidative Radiation for Borderline and Locally Advanced Unresectable Pancreatic Cancer. Pancreas 2020, 49: 904-911. PMID: 32658074, DOI: 10.1097/mpa.0000000000001592.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaLA PDACUnresectable pancreatic ductal adenocarcinomaInduction FOLFIRINOXConsolidative radiotherapyOverall survivalAdvanced unresectable pancreatic ductal adenocarcinomaSingle-center retrospective reviewMeaningful survival benefitMedian overall survivalUnresectable pancreatic cancerR0 resection rateKaplan-Meier methodSingle institution experienceBenefits of surgeryLog-rank testConsolidative radiationDefinitive radiationLA patientsPreoperative radiationResection rateSurgery patientsSurvival benefitSurvival impactImproved survival