2004
Burn Injury and Pulmonary Sepsis: Development of a Clinically Relevant Model
Davis KA, Santaniello JM, He LK, Muthu K, Sen S, Jones SB, Gamelli RL, Shankar R. Burn Injury and Pulmonary Sepsis: Development of a Clinically Relevant Model. Journal Of Trauma And Acute Care Surgery 2004, 56: 272-278. PMID: 14960967, DOI: 10.1097/01.ta.0000108995.64133.90.Peer-Reviewed Original ResearchConceptsColony-stimulating factorPulmonary sepsisCytokine tumor necrosisSystemic sepsisInterleukin-6Tumor necrosisProinflammatory cytokine tumor necrosisInflammatory cytokine tumor necrosisAlveolar macrophage releaseBurn/traumaDorsal scald burnGram stainMultiple organ failureDevelopment of pneumoniaGranulocyte-macrophage (GM) CSFFemoral bone marrow cellsEnd-organ responseIsolated alveolar macrophagesPositive tissue culturesPseudomonas aeruginosaWhole lung tissueMale B6D2F1 miceTissue Gram stainMacrophage colony-stimulating factorBone marrow cells
2001
COMBINATION THERAPY THAT TARGETS SECONDARY PULMONARY CHANGES AFTER ABDOMINAL TRAUMA
Davis K, Fabian T, Ragsdale D, Trenthem L, Croce M, Proctor K. COMBINATION THERAPY THAT TARGETS SECONDARY PULMONARY CHANGES AFTER ABDOMINAL TRAUMA. Shock 2001, 15: 479-484. PMID: 11386622, DOI: 10.1097/00024382-200115060-00012.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal AbscessAbdominal InjuriesAminoimidazole CarboxamideAnimalsAnti-Inflammatory AgentsBlood PressureCapillariesDisease Models, AnimalHemodynamicsInflammationLactatesLungLung InjuryNeutrophilsPulmonary AlveoliPulmonary ArteryResuscitationRibonucleotidesShock, HemorrhagicSteroidsSwineConceptsSecondary lung injuryAbdominal traumaG-CSFPMN activationLung injuryHemorrhagic shockAnalysis of BALLate septic complicationsLavage leukocyte countPulmonary reperfusion injurySecondary pulmonary changesAnti-inflammatory drugsAnti-inflammatory metabolitesWhite blood cellsNeutrophil sequestrationPulmonary contusionSeptic complicationsPMN infiltrationPulmonary changesReperfusion injurySecondary injuryResuscitation strategiesShed bloodCombination therapyEndogenous adenosine
2000
Endogenous Adenosine and Secondary Injury after Chest Trauma
Davis K, Fabian T, Ragsdale D, Trenthem L, Proctor A. Endogenous Adenosine and Secondary Injury after Chest Trauma. Journal Of Trauma And Acute Care Surgery 2000, 49: 892-898. PMID: 11086782, DOI: 10.1097/00005373-200011000-00017.Peer-Reviewed Original ResearchConceptsBlunt chest traumaBlunt chest injuryChest traumaAdenosine-regulating agentSecondary injuryBAL proteinChest injuriesEndogenous adenosineLung myeloperoxidase levelsTime of resuscitationAnti-inflammatory actionProgressive inflammatory responseAction of adenosineAlveolar-capillary membraneWet-dry ratioBAL WBCPulmonary contusionContralateral lungMyeloperoxidase levelsSystemic hemodynamicsUninjured lungsLung edemaRight chestMongrel pigsPathophysiologic changes
1999
Granulocyte colony-stimulating factor and neutrophil-related changes in local host defense during recovery from shock and intra-abdominal sepsis
Davis K, Fabian T, Ragsdale D, Trenthem L, Croce M, Proctor K. Granulocyte colony-stimulating factor and neutrophil-related changes in local host defense during recovery from shock and intra-abdominal sepsis. Surgery 1999, 126: 305-313. PMID: 10455899, DOI: 10.1016/s0039-6060(99)70170-4.Peer-Reviewed Original ResearchConceptsGranulocyte colony-stimulating factorG-CSFColony-stimulating factorPMN cytotoxicityReperfusion injurySeptic focusPeritoneal PMNsResuscitation fluidExogenous granulocyte colony-stimulating factorIntra-abdominal septic focusLung tissue myeloperoxidaseIntra-abdominal sepsisBronchoalveolar lavage proteinLocal host defenseSaline solution vehicleBroad-spectrum antibioticsBronchoalveolar lavage PMNsLavage PMNsPeritoneal neutrophiliaTissue myeloperoxidaseSeptic complicationsAbdominal traumaPMN infiltrationTrauma patientsCecal ligationMediator-dependent secondary injury after unilateral blunt thoracic trauma.
Melton S, Davis K, Moomey C, Fabian T, Proctor K. Mediator-dependent secondary injury after unilateral blunt thoracic trauma. Shock 1999, 11: 396-402. PMID: 10454828.Peer-Reviewed Original ResearchConceptsChest traumaNaive recipientsRespiratory failureTube thoracostomyCross-transfusion experimentsEarly pharmacologic interventionBlunt chest traumaPulmonary vascular resistanceSevere chest traumaBlunt thoracic traumaVascular resistanceSupportive careCardiopulmonary changesThoracic traumaExchange transfusionLung compliancePathophysiologic sequencePrimary injurySecondary injuryMediator productionCardiac outputPharmacologic interventionsHistologic changesInflammatory processStroke volumeProstanoids
Davis K, Fabian T, Croce M, Proctor K. Prostanoids. Journal Of Trauma And Acute Care Surgery 1999, 46: 824-832.. PMID: 10338399, DOI: 10.1097/00005373-199905000-00010.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressurePulmonary capillary leakEnd-expiratory pressurePMN infiltrationPulmonary failureRight thoraxSecondary injuryInflammatory responseCapillary leakPlatelet-derived thromboxaneBlunt chest traumaHours of injurySecondary inflammatory responseBronchoalveolar lavage proteinSerial bronchoalveolar lavagesCyclooxygenase inhibitor indomethacinUnilateral pulmonary contusionPulmonary contusionChest traumaProfound hypoxemiaSham injuryBlunt injuryLeft lungBronchoalveolar lavageNeutrophil content