2023
Longitudinal Pathways Between Physical Activity, Depression, and Perceived Stress in Peripheral Artery Disease.
Yazgan I, Bartlett V, Romain G, Cleman J, Petersen-Crair P, Spertus J, Hardt M, Mena-Hurtado C, Smolderen K. Longitudinal Pathways Between Physical Activity, Depression, and Perceived Stress in Peripheral Artery Disease. Circulation Cardiovascular Quality And Outcomes 2023, 16: 544-553. PMID: 37470195, PMCID: PMC10561081, DOI: 10.1161/circoutcomes.122.009840.Peer-Reviewed Original ResearchConceptsPhysical activityPAD diagnosisDepressive symptomsLower physical activity scoresPerceived stressVascular specialty clinicsPeripheral artery diseasePhysical activity scoreSignificant depressive symptomsPatient Health QuestionnaireBehavioral health approachesSubsequent depressive symptomsINTERHEART studySymptomatic PADCardiovascular eventsPAD symptomsArtery diseaseInitial presentationActivity scoreSpecialty clinicHealth QuestionnairePatient's abilityTreatment goalsPAD managementPerceived Stress Scale
2020
Association of Diabetes Mellitus With Health Status Outcomes in Patients With Peripheral Artery Disease: Insights From the PORTRAIT Registry
Patel KK, Alturkmani H, Gosch K, Mena‐Hurtado C, Shishehbor MH, Peri‐Okonny P, Creager MA, Spertus JA, Smolderen KG. Association of Diabetes Mellitus With Health Status Outcomes in Patients With Peripheral Artery Disease: Insights From the PORTRAIT Registry. Journal Of The American Heart Association 2020, 9: e017103. PMID: 33153398, PMCID: PMC7763706, DOI: 10.1161/jaha.120.017103.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePAQ summary scoreDiabetes mellitusHealth statusArtery diseaseSummary scoresEffect of DMInteraction of DMPAD-specific health statusSymptomatic peripheral artery diseaseAdverse limb eventsHealth status benefitsBaseline health statusHealth status outcomesPoor health statusHealth status gainsComorbidity burdenPAD progressionPAD severityPORTRAIT registryBackground PatientsConclusions PatientsInternational registryRecent exacerbationSpecialty clinicMental health concerns in patients with symptomatic peripheral artery disease: Insights from the PORTRAIT registry
Thomas M, Patel KK, Gosch K, Labrosciano C, Mena-Hurtado C, Fitridge R, Spertus JA, Smolderen KG. Mental health concerns in patients with symptomatic peripheral artery disease: Insights from the PORTRAIT registry. Journal Of Psychosomatic Research 2020, 131: 109963. PMID: 32065970, PMCID: PMC7417281, DOI: 10.1016/j.jpsychores.2020.109963.Peer-Reviewed Original ResearchGeneralized Anxiety Disorder Scale-2Peripheral artery diseasePatient Health Questionnaire-8Mental health concernsSymptoms of depressionPerceived Stress Scale-4Health concernArtery diseaseSymptomatic peripheral artery diseaseInitial office visitWarrants further investigationPORTRAIT registryPatient characteristicsOffice visitsSpecialty clinicSpecialty settingsPatient profilesPAD managementPatientsHealth statusRole of stressSymptomsHigh levelsDepressionDiseaseAdherence to Guideline‐Recommended Therapy—Including Supervised Exercise Therapy Referral—Across Peripheral Artery Disease Specialty Clinics: Insights From the International PORTRAIT Registry
Saxon JT, Safley DM, Mena‐Hurtado C, Heyligers J, Fitridge R, Shishehbor M, Spertus JA, Gosch K, Patel MR, Smolderen KG. Adherence to Guideline‐Recommended Therapy—Including Supervised Exercise Therapy Referral—Across Peripheral Artery Disease Specialty Clinics: Insights From the International PORTRAIT Registry. Journal Of The American Heart Association 2020, 9: e012541. PMID: 31973609, PMCID: PMC7033887, DOI: 10.1161/jaha.119.012541.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmbulatory Care FacilitiesAustraliaCardiovascular AgentsExercise TherapyFemaleGuideline AdherenceHealthcare DisparitiesHumansMaleMiddle AgedNetherlandsPeripheral Arterial DiseasePractice Guidelines as TopicPractice Patterns, Physicians'Prospective StudiesQuality Indicators, Health CareReferral and ConsultationRegistriesUnited StatesConceptsSupervised exercise therapyPeripheral artery diseaseGuideline-recommended therapiesMedian odds ratioPORTRAIT registryAntiplatelet medicationsPAD symptomsOdds ratioSpecialty clinicSpecialty care facilityEvidence-based careCessation counselingExercise therapyCurrent smokersArtery diseaseCare facilitiesPatientsTherapy/counselingUS sitesReferralTherapyStatinsProcedural databaseQuality measuresMedications
2018
Guideline‐directed statin intensification in patients with new or worsening symptoms of peripheral artery disease
Khariton Y, Patel KK, Chan PS, Pokharel Y, Wang J, Spertus JA, Safley DM, Hiatt WR, Smolderen KG. Guideline‐directed statin intensification in patients with new or worsening symptoms of peripheral artery disease. Clinical Cardiology 2018, 41: 1414-1422. PMID: 30284297, PMCID: PMC6489902, DOI: 10.1002/clc.23087.Peer-Reviewed Original ResearchMeSH KeywordsAgedAustraliaDisease ProgressionDyslipidemiasFemaleGuideline AdherenceHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIntermittent ClaudicationMaleMiddle AgedNetherlandsPeripheral Arterial DiseasePractice Guidelines as TopicPractice Patterns, Physicians'Prospective StudiesRegistriesTime FactorsTreatment OutcomeUnited StatesConceptsPeripheral artery diseaseAdjusted median odds ratioStatin intensificationClaudication symptomsStatin therapyGuideline therapyArtery diseaseSpecialty clinicACC/AHA cholesterol guidelinesHigh-intensity statin treatmentHigh-intensity statinsLow-intensity statinsProvider-level variationMedian odds ratioCholesterol guidelinesPORTRAIT registryMost patientsOlder patientsPAD symptomsStatin treatmentMedical therapyPatient factorsAppropriate therapyOdds ratioLower oddsUnderutilization of Evidence‐Based Smoking Cessation Support Strategies Despite High Smoking Addiction Burden in Peripheral Artery Disease Specialty Care: Insights from the International PORTRAIT Registry
Patel KK, Jones PG, Ellerbeck EF, Buchanan DM, Chan PS, Pacheco CM, Moneta G, Spertus JA, Smolderen KG. Underutilization of Evidence‐Based Smoking Cessation Support Strategies Despite High Smoking Addiction Burden in Peripheral Artery Disease Specialty Care: Insights from the International PORTRAIT Registry. Journal Of The American Heart Association 2018, 7: e010076. PMID: 30371269, PMCID: PMC6474973, DOI: 10.1161/jaha.118.010076.Peer-Reviewed Original ResearchConceptsVascular specialty clinicsPeripheral artery diseaseCessation interventionsActive smokersSpecialty clinicEvidence-based cessation interventionsThird of patientsProbability of relapseImportant risk factorBackground SmokingInitial quittersPORTRAIT registryCessation counselingPharmacologic treatmentArtery diseaseInitial visitSmoking statusCessation supportSmoking cessationTreatment courseSpecialty careRisk factorsSmoking ratesPAD managementPatients