2023
Patient knowledge and preferences for peripheral artery disease treatment
Smolderen K, Romain G, Gosch K, Arham A, Provance J, Spertus J, Poosala A, Shishehbor M, Safley D, Scott K, Stone N, Mena-Hurtado C. Patient knowledge and preferences for peripheral artery disease treatment. Vascular Medicine 2023, 28: 397-403. PMID: 37638882, PMCID: PMC10591804, DOI: 10.1177/1358863x231181613.Peer-Reviewed Original ResearchPeripheral artery diseaseTreatment goalsPatient knowledgeTreatment optionsTreatment preferencesHeart attack/strokeSymptomatic peripheral artery diseasePeripheral artery disease treatmentImportant treatment goalQuality of lifeCost of treatmentSpecific treatment goalsMulticenter registryPAD symptomsPain reliefSecondary preventionArtery diseaseTreatment choiceTreatment benefitPatient understandingPatientsMedical decision makingDisease managementClaudicationDisease treatmentLongitudinal Pathways Between Physical Activity, Depression, and Perceived Stress in Peripheral Artery Disease.
Yazgan I, Bartlett V, Romain G, Cleman J, Petersen-Crair P, Spertus J, Hardt M, Mena-Hurtado C, Smolderen K. Longitudinal Pathways Between Physical Activity, Depression, and Perceived Stress in Peripheral Artery Disease. Circulation Cardiovascular Quality And Outcomes 2023, 16: 544-553. PMID: 37470195, PMCID: PMC10561081, DOI: 10.1161/circoutcomes.122.009840.Peer-Reviewed Original ResearchConceptsPhysical activityPAD diagnosisDepressive symptomsLower physical activity scoresPerceived stressVascular specialty clinicsPeripheral artery diseasePhysical activity scoreSignificant depressive symptomsPatient Health QuestionnaireBehavioral health approachesSubsequent depressive symptomsINTERHEART studySymptomatic PADCardiovascular eventsPAD symptomsArtery diseaseInitial presentationActivity scoreSpecialty clinicHealth QuestionnairePatient's abilityTreatment goalsPAD managementPerceived Stress ScalePredictors of Revascularization in Lower-Extremity Peripheral Artery Disease: Insights From the PORTRAIT Study.
Pokharel Y, Kokkinidis D, Wang J, Gosch K, Safley D, Spertus J, Mena-Hurtado C, Smolderen K. Predictors of Revascularization in Lower-Extremity Peripheral Artery Disease: Insights From the PORTRAIT Study. Journal Of Endovascular Therapy 2023, 15266028231179574. PMID: 37309164, DOI: 10.1177/15266028231179574.Peer-Reviewed Original ResearchPredictors of revascularizationEarly revascularizationPeripheral artery diseaseExtensive diseasePAD symptomsSymptom burdenArtery diseaseOdds ratioLower Extremity Peripheral Artery DiseaseAnkle-brachial index scoreGoal-directed medical therapyEarly revascularization proceduresKnee arterial segmentsLifestyle-limiting claudicationRutherford class 3Peripheral arterial diseaseMonths of presentationPatient-level predictorsLower extremity PADMain predictorsMedian odds ratioHierarchical logistic regressionSymptomatic PADDisease guidelinesMedical therapy
2022
Real-world abdominal aorta aneurysm screening patterns among patients with new or worsening of symptomatic peripheral artery disease
Lee M, Pichert M, Tran A, Farooq A, Heyligers J, de Vries J, Spertus J, Guzman R, Thomas M, Mena-Hurtado C, Smolderen K. Real-world abdominal aorta aneurysm screening patterns among patients with new or worsening of symptomatic peripheral artery disease. International Journal Of Cardiology 2022, 375: 94-97. PMID: 36577485, PMCID: PMC10371801, DOI: 10.1016/j.ijcard.2022.12.042.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseAbdominal aortic aneurysmScreening ratesArtery diseaseSpecialty centersAdjusted median odds ratioSymptomatic peripheral artery diseaseInternational prospective registryHigh-risk populationMedian odds ratioAbdominal aorta aneurysmAAA positivityMulticenter registryPAD symptomsProspective registryGuideline implementationAortic aneurysmAAA screeningAorta aneurysmOdds ratioPAD managementDisease RegistryPatientsMedian oddsClinical sitesAssociation of Disease‐Specific Health Status With Long‐Term Survival in Peripheral Artery Disease
Tran AT, Spertus JA, Mena‐Hurtado C, Jones PG, Aronow HD, Safley DM, Malik AO, Peri‐Okonny P, Shishehbor MH, Labrosciano C, Smolderen KG. Association of Disease‐Specific Health Status With Long‐Term Survival in Peripheral Artery Disease. Journal Of The American Heart Association 2022, 11: e022232. PMID: 35132874, PMCID: PMC9245831, DOI: 10.1161/jaha.121.022232.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePAD-specific health statusHealth statusPAD symptomsArtery diseaseHierarchical Cox regression modelsDisease-specific health statusLong-term mortality riskTime of diagnosisCox regression modelLong-term survivalPORTRAIT registryCardiovascular morbidityCause mortalityResults PatientsKaplan-MeierMortality riskUnadjusted modelsSummary scoresUS sitesPatientsMortalityBaselineSymptomsDisease
2021
Patient representativeness of a peripheral artery disease cohort in a randomized control trial versus a real-world cohort: The CLEVER trial versus the PORTRAIT registry
Scierka LE, Jelani QU, Smolderen KG, Gosch K, Spertus JA, Mena-Hurtado C, Jones P, Dreyer RP. Patient representativeness of a peripheral artery disease cohort in a randomized control trial versus a real-world cohort: The CLEVER trial versus the PORTRAIT registry. Contemporary Clinical Trials 2021, 112: 106624. PMID: 34793986, DOI: 10.1016/j.cct.2021.106624.Peer-Reviewed Original ResearchConceptsOptimal medical therapyPeripheral artery diseasePatient characteristicsBaseline patient characteristicsPAD cohortPAD populationPORTRAIT registryExercise therapyPAD patientsPAD symptomsArtery diseaseFinal cohortMedical therapyProspective studyBurdensome diseaseControl trialHealth statusPatientsTherapyCohortCLEVER studyDiseaseMulticenterRevascularizationRCTsAssociation of sleep apnea with outcomes in peripheral artery disease: Insights from the PORTRAIT study
Jelani QU, Mena-Hurtado C, Gosch K, Mohammed M, Labrosciano C, Regan C, Scierka LE, Spertus JA, Nagpal S, Smolderen KG. Association of sleep apnea with outcomes in peripheral artery disease: Insights from the PORTRAIT study. PLOS ONE 2021, 16: e0256933. PMID: 34506511, PMCID: PMC8432750, DOI: 10.1371/journal.pone.0256933.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePeripheral Artery QuestionnaireSleep apneaHealth statusArtery diseaseSummary scoresDisease-specific Peripheral Artery QuestionnaireFive-year survival curvesHigh ankle-brachial indexPAQ summary scoreVascular specialty clinicsAnkle-brachial indexLog-rank testSleep apnea statusHealth status outcomesWorse health statusQuality of lifeBetter health statusCause mortalityMultivariable adjustmentPAD symptomsCoronary diseasePeripheral interventionsUS patientsMean ageVariability in utilization of diagnostic imaging tests in patients with symptomatic peripheral artery disease
Derbas LA, Patel KK, Muskula PR, Wang J, Gosch K, Fitridge R, Spertus JA, Smolderen KG. Variability in utilization of diagnostic imaging tests in patients with symptomatic peripheral artery disease. International Journal Of Cardiology 2021, 330: 200-206. PMID: 33581177, DOI: 10.1016/j.ijcard.2021.02.014.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseMedian odds ratioImaging testsSymptomatic peripheral artery diseaseSymptomatic peripheral arterial diseaseInvasive imaging testsPAQ summary scoreVascular specialty clinicsPatient-level factorsPeripheral artery diseaseDiagnostic imaging testsHierarchical logistic regression modelsLogistic regression modelsMean ABIPAD diagnosisNew onsetPAD symptomsPatient demographicsArtery diseasePatient characteristicsVascular clinicArterial diseaseDisease characteristicsRecent exacerbationReferral rates
2020
Relationship Between Depressive Symptoms and Health Status in Peripheral Artery Disease: Role of Sex Differences
Jelani Q, Mena‐Hurtado C, Burg M, Soufer R, Gosch K, Jones PG, Spertus JA, Safdar B, Smolderen KG. Relationship Between Depressive Symptoms and Health Status in Peripheral Artery Disease: Role of Sex Differences. Journal Of The American Heart Association 2020, 9: e014583. PMID: 32781883, PMCID: PMC7660812, DOI: 10.1161/jaha.119.014583.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseDepressive symptomsHealth statusArtery diseaseEQ-5D visual analog scale scoresEQ-5D visual analog scaleVisual analog scale scoreGeneric health statusPeripheral Artery QuestionnaireVascular specialty clinicsAnalog scale scoreHealth status scoresPatient Health QuestionnaireSevere depressive symptomsVisual analog scaleHealth status outcomesWorse health statusAdjusted general linear modelSex differencesPORTRAIT registryPAD diagnosisPAD symptomsAnalog scaleConclusions WomenMean agePatient profiles and health status outcomes for peripheral artery disease in high-income countries: a comparison between the USA and The Netherlands
Jelani QU, Smolderen KG, Halpin D, Gosch K, Spertus JA, Chaar C, Nolthenius R, Heyligers J, De Vries JP, Mena-Hurtado C. Patient profiles and health status outcomes for peripheral artery disease in high-income countries: a comparison between the USA and The Netherlands. European Heart Journal - Quality Of Care And Clinical Outcomes 2020, 7: 505-512. PMID: 32539108, DOI: 10.1093/ehjqcco/qcaa052.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseHealth status scoresHealth status outcomesStatus scoreStatus outcomesArtery diseaseUS patientsHigh-income countriesPatient profilesCardiovascular risk factor burdenPAD-specific health statusPeripheral Artery QuestionnaireRisk factor burdenVascular specialty clinicsPeripheral arterial diseasePatient-centered outcomesLow referral ratesMore financial barriersPAD carePAD outcomesNew onsetPAD symptomsArterial diseaseExercise treatmentReferral ratesAdherence to Guideline‐Recommended Therapy—Including Supervised Exercise Therapy Referral—Across Peripheral Artery Disease Specialty Clinics: Insights From the International PORTRAIT Registry
Saxon JT, Safley DM, Mena‐Hurtado C, Heyligers J, Fitridge R, Shishehbor M, Spertus JA, Gosch K, Patel MR, Smolderen KG. Adherence to Guideline‐Recommended Therapy—Including Supervised Exercise Therapy Referral—Across Peripheral Artery Disease Specialty Clinics: Insights From the International PORTRAIT Registry. Journal Of The American Heart Association 2020, 9: e012541. PMID: 31973609, PMCID: PMC7033887, DOI: 10.1161/jaha.119.012541.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmbulatory Care FacilitiesAustraliaCardiovascular AgentsExercise TherapyFemaleGuideline AdherenceHealthcare DisparitiesHumansMaleMiddle AgedNetherlandsPeripheral Arterial DiseasePractice Guidelines as TopicPractice Patterns, Physicians'Prospective StudiesQuality Indicators, Health CareReferral and ConsultationRegistriesUnited StatesConceptsSupervised exercise therapyPeripheral artery diseaseGuideline-recommended therapiesMedian odds ratioPORTRAIT registryAntiplatelet medicationsPAD symptomsOdds ratioSpecialty clinicSpecialty care facilityEvidence-based careCessation counselingExercise therapyCurrent smokersArtery diseaseCare facilitiesPatientsTherapy/counselingUS sitesReferralTherapyStatinsProcedural databaseQuality measuresMedications
2019
Financial barriers in accessing medical care for peripheral artery disease are associated with delay of presentation and adverse health status outcomes in the United States
Jelani QU, Jhamnani S, Spatz ES, Spertus J, Smolderen KG, Wang J, Desai NR, Jones P, Gosch K, Shah S, Attaran R, Mena-Hurtado C. Financial barriers in accessing medical care for peripheral artery disease are associated with delay of presentation and adverse health status outcomes in the United States. Vascular Medicine 2019, 25: 13-24. PMID: 31603393, DOI: 10.1177/1358863x19872542.Peer-Reviewed Original ResearchMeSH KeywordsAgedFemaleHealth Care CostsHealth Services AccessibilityHealth Status DisparitiesHealthcare DisparitiesHumansInsurance, HealthMaleMedically UninsuredMiddle AgedPatient Reported Outcome MeasuresPeripheral Arterial DiseaseProspective StudiesQuality of LifeRisk FactorsTime FactorsTime-to-TreatmentUnited StatesConceptsPeripheral artery diseasePeripheral Artery QuestionnaireHealth status outcomesHealth statusArtery diseaseStatus outcomesFinancial barriersGeneral health-related qualityDisease-specific health statusPatient-reported health statusDelay of presentationPatient-reported difficultyVascular specialty clinicsPeripheral arterial diseaseEuroQol-5 DimensionsHealth-related qualityPoor health statusUnited States patientsMulticenter registryMultivariable adjustmentPAD symptomsArterial diseaseTreatment patternsUS patientsLate presentation
2018
Guideline‐directed statin intensification in patients with new or worsening symptoms of peripheral artery disease
Khariton Y, Patel KK, Chan PS, Pokharel Y, Wang J, Spertus JA, Safley DM, Hiatt WR, Smolderen KG. Guideline‐directed statin intensification in patients with new or worsening symptoms of peripheral artery disease. Clinical Cardiology 2018, 41: 1414-1422. PMID: 30284297, PMCID: PMC6489902, DOI: 10.1002/clc.23087.Peer-Reviewed Original ResearchMeSH KeywordsAgedAustraliaDisease ProgressionDyslipidemiasFemaleGuideline AdherenceHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIntermittent ClaudicationMaleMiddle AgedNetherlandsPeripheral Arterial DiseasePractice Guidelines as TopicPractice Patterns, Physicians'Prospective StudiesRegistriesTime FactorsTreatment OutcomeUnited StatesConceptsPeripheral artery diseaseAdjusted median odds ratioStatin intensificationClaudication symptomsStatin therapyGuideline therapyArtery diseaseSpecialty clinicACC/AHA cholesterol guidelinesHigh-intensity statin treatmentHigh-intensity statinsLow-intensity statinsProvider-level variationMedian odds ratioCholesterol guidelinesPORTRAIT registryMost patientsOlder patientsPAD symptomsStatin treatmentMedical therapyPatient factorsAppropriate therapyOdds ratioLower oddsPORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease
Smolderen KG, Gosch K, Patel M, Jones WS, Hirsch AT, Beltrame J, Fitridge R, Shishehbor MH, Denollet J, Vriens P, Heyligers J, Stone MEd N, Aronow H, Abbott JD, Labrosciano C, Tutein-Nolthenius R, A Spertus J. PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease. Circulation Cardiovascular Quality And Outcomes 2018, 11: e003860. PMID: 29440123, DOI: 10.1161/circoutcomes.117.003860.Peer-Reviewed Original ResearchMeSH KeywordsAgedAustraliaCardiovascular AgentsExercise TherapyFemaleHealth StatusHealth Status IndicatorsHealthcare DisparitiesHumansIntermittent ClaudicationLife StyleMaleMiddle AgedMulticenter Studies as TopicNetherlandsPatient Outcome AssessmentPeripheral Arterial DiseaseProspective StudiesQuality of LifeRegistriesResearch DesignRisk FactorsSurveys and QuestionnairesTime FactorsTreatment OutcomeUnited StatesVascular Surgical ProceduresConceptsHealth status outcomesHealth statusMedical historyMedical recordsStatus outcomesAbnormal ankle-brachial indexPAD-related hospitalizationAnkle-brachial indexCardiovascular risk factorsMajor cardiovascular eventsPatients' medical recordsComparative effectiveness studiesHealth status dataPatient's medical historyPatients' health statusQuality of lifeClaudication symptomsEligible patientsCardiovascular eventsPAD symptomsPatient characteristicsClinician adherenceRisk stratificationLifestyle factorsFunctional status
2017
Sex differences in disease-specific health status measures in patients with symptomatic peripheral artery disease: Data from the PORTRAIT study
Roumia M, Aronow HD, Soukas P, Gosch K, Smolderen KG, Spertus JA, Abbott JD. Sex differences in disease-specific health status measures in patients with symptomatic peripheral artery disease: Data from the PORTRAIT study. Vascular Medicine 2017, 22: 103-109. PMID: 28429659, DOI: 10.1177/1358863x16686408.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnkle Brachial IndexAustraliaChi-Square DistributionCost of IllnessFemaleHealth Status DisparitiesHealth Status IndicatorsHumansIntermittent ClaudicationLinear ModelsLogistic ModelsMaleMental HealthMiddle AgedMultivariate AnalysisNetherlandsPatient SatisfactionPeripheral Arterial DiseasePrognosisProspective StudiesQuality of LifeRisk FactorsSeverity of Illness IndexSex FactorsSocial BehaviorSocioeconomic FactorsSurveys and QuestionnairesUnited StatesConceptsPeripheral artery diseasePeripheral Artery QuestionnaireHealth statusArtery diseaseSymptoms of PADAnkle-brachial index valuesPAD-specific health statusSymptomatic peripheral artery diseaseDisease-specific health status measuresPAQ scoresPeripheral arterial diseaseSex differencesHealth status domainsInternational prospective studyPoor health statusHealth status measuresMultivariable linear regressionLower PAQ scoresBaseline characteristicsClinical characteristicsPAD symptomsTreatment satisfactionArterial diseaseProspective studyFemale sex
2015
One Year Health Status Benefits Following Treatment for New Onset or Exacerbation of Peripheral Arterial Disease Symptoms: The Importance of Patients' Baseline Health Status
van Zitteren M, Denollet J, Heyligers JM, Elshof JW, Nooren MJ, Burger DH, de Fijter WM, Vriens PW, Smolderen KG. One Year Health Status Benefits Following Treatment for New Onset or Exacerbation of Peripheral Arterial Disease Symptoms: The Importance of Patients' Baseline Health Status. European Journal Of Vascular And Endovascular Surgery 2015, 50: 213-222. PMID: 26036809, DOI: 10.1016/j.ejvs.2015.04.003.Peer-Reviewed Original ResearchMeSH KeywordsAgedDisease ProgressionFemaleHealth StatusHealth Status IndicatorsHumansLinear ModelsMaleMental HealthMiddle AgedNetherlandsPeripheral Arterial DiseasePredictive Value of TestsPropensity ScoreProspective StudiesRecovery of FunctionRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeUltrasonography, Doppler, DuplexConceptsHealth status scoresPeripheral arterial diseaseHealth status gainsBaseline health statusInvasive treatmentStatus scoreHealth statusPatient's baseline health statusPeripheral arterial disease symptomsHealth status levelsHealth status outcomesNew onsetPAD symptomsVascular clinicArterial diseaseHighest quartilePCS scoresInvasive strategyTreatment strategiesClinical informationStatus outcomesPatientsLinear regression analysisChange scoresExacerbation
2014
Determinants of invasive treatment in lower extremity peripheral arterial disease
van Zitteren M, Vriens PW, Burger DH, de Fijter WM, Gerritsen GP, Heyligers JM, Nooren MJ, Smolderen KG. Determinants of invasive treatment in lower extremity peripheral arterial disease. Journal Of Vascular Surgery 2014, 59: 400-408.e2. PMID: 24461863, DOI: 10.1016/j.jvs.2013.08.045.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnkle Brachial IndexChi-Square DistributionDecision Support TechniquesEndovascular ProceduresFemaleHealth StatusHumansLower ExtremityMaleMiddle AgedNetherlandsOdds RatioPatient SelectionPeripheral Arterial DiseasePredictive Value of TestsProspective StudiesReferral and ConsultationRisk FactorsTreatment OutcomeUltrasonography, Doppler, DuplexVascular Surgical ProceduresConceptsPeripheral arterial diseaseLower extremity peripheral arterial diseasePhysical component scaleInvasive treatmentLesion locationHealth statusArterial diseaseTreatment referralSymptomatic lower extremity peripheral arterial diseaseProspective observational cohort studyVascular surgery outpatient clinicProximal lesion locationAnkle-brachial indexObservational cohort studySurgery outpatient clinicShort Form-12Poor health statusPatients' health statusPoisson regression analysisPAD diagnosisCohort studyPAD symptomsIndependent predictorsAmbulatory patientsForm-12