2024
Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation
Xin T, Gallini S, Wei H, Gonzalez D, Matte-Martone C, Machida H, Fujiwara H, Pasolli H, Suozzi K, Gonzalez L, Regot S, Greco V. Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation. Nature Cell Biology 2024, 26: 859-867. PMID: 38689013, PMCID: PMC11519783, DOI: 10.1038/s41556-024-01413-y.Peer-Reviewed Original ResearchERK signalingStem cellsSquamous cell carcinomaHair folliclesOncogenic KRAS mutationsCell carcinomaKRAS mutationsSustained ERK activationERK signaling dynamicsOncogenic mutationsOncogenic KRASERK activationStem cell behaviorIntravital imagingAbnormal cell divisionModulates specific featuresKrasG12DTissue deformationSpatiotemporally specific mannerSustained ERK signalingMutationsLiving miceFolliclesTissue disruptionSingle-cell level
2022
Evidence-Based Clinical Practice Guidelines for Laser-Assisted Drug Delivery
Labadie JG, Ibrahim SA, Worley B, Kang BY, Rakita U, Rigali S, Arndt KA, Bernstein E, Brauer JA, Chandra S, Didwania A, DiGiorgio C, Donelan M, Dover JS, Galadari H, Geronemus RG, Goldman MP, Haedersdal M, Hruza G, Ibrahimi OA, Kauvar A, Kelly KM, Krakowski AC, Miest R, Orringer JS, Ozog DM, Ross EV, Shumaker PR, Sobanko JF, Suozzi K, Taylor MB, Teng JMC, Uebelhoer NS, Waibel J, Wanner M, Ratchev I, Christensen RE, Poon E, Miller CH, Alam M. Evidence-Based Clinical Practice Guidelines for Laser-Assisted Drug Delivery. JAMA Dermatology 2022, 158: 1193-1201. PMID: 35976634, DOI: 10.1001/jamadermatol.2022.3234.Peer-Reviewed Original ResearchConceptsLaser-assisted drug deliveryEvidence-based clinical practice guidelinesFractional laser-assisted drug deliveryClinical practice guidelinesPractice guidelinesSystematic reviewCutaneous squamous cell carcinomaCochrane Central RegisterExpert panelSquamous cell carcinomaDelphi consensus approachImpaired wound healingFitzpatrick skin typeEvidence-based guidanceAntibiotic prophylaxisAntifungal prophylaxisAntiviral prophylaxisDermal analgesiaCentral RegisterControlled TrialsActinic keratosisCell carcinomaActinic cheilitisMultidisciplinary panelInclusion criteria
2021
A Histopathologic Scoring System for Perineural Invasion Correlates With Adverse Outcomes in Patients With Cutaneous Squamous Cell Carcinoma.
Totonchy MB, McNiff JM, Suozzi KC, Leffell DJ, Christensen SR. A Histopathologic Scoring System for Perineural Invasion Correlates With Adverse Outcomes in Patients With Cutaneous Squamous Cell Carcinoma. Dermatologic Surgery 2021, 47: 445-451. PMID: 33795563, DOI: 10.1097/dss.0000000000002923.Peer-Reviewed Original ResearchConceptsCutaneous squamous cell carcinomaPerineural invasionSquamous cell carcinomaAdverse outcomesNerve diameterHistopathologic featuresPNI scoreCell carcinomaExtratumoral perineural invasionRetrospective cohort studyCurrent staging systemHistopathologic scoring systemTumor-related deathNumber of nervesLogistic regression analysisMedian followNerve involvementCohort studyLocal recurrenceSurgical excisionStaging systemRisk factorsMedian numberHistopathologic slidesNerve structures
2020
Cutaneous Photoprotection: A Review of the Current Status and Evolving Strategies.
Suozzi K, Turban J, Girardi M. Cutaneous Photoprotection: A Review of the Current Status and Evolving Strategies. The Yale Journal Of Biology And Medicine 2020, 93: 55-67. PMID: 32226337, PMCID: PMC7087054.Peer-Reviewed Original ResearchConceptsCutaneous squamous cell carcinomaBasal cell carcinomaCell carcinomaRisk factorsMajor environmental risk factorSquamous cell carcinomaAdditional risk factorsEnvironmental risk factorsDevelopment of melanomaUltraviolet radiation exposureLifestyle modificationTopical therapyImmune statusCutaneous carcinogenesisImmune factorsCell malignant transformationDrug Administration regulationsInsufficient evidenceMultifactorial mechanismsSkin cancerMalignant transformationFavorable aestheticsTumor developmentClonal expansionRadiation exposure