2017
Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice
Fuster JJ, MacLauchlan S, Zuriaga MA, Polackal MN, Ostriker AC, Chakraborty R, Wu CL, Sano S, Muralidharan S, Rius C, Vuong J, Jacob S, Muralidhar V, Robertson AA, Cooper MA, Andrés V, Hirschi KK, Martin KA, Walsh K. Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice. Science 2017, 355: 842-847. PMID: 28104796, PMCID: PMC5542057, DOI: 10.1126/science.aag1381.Peer-Reviewed Original ResearchConceptsTET2-deficient cellsLow-density lipoprotein receptor-deficient miceLipoprotein receptor-deficient miceClonal hematopoiesisBlood cellsAtherosclerotic cardiovascular diseaseAtherosclerotic plaque sizeReceptor-deficient miceBone marrow reconstitutionInterleukin-1β secretionMutant blood cellsAtherosclerosis developmentNLRP3 inhibitorAtheroprotective activityCardiovascular diseaseMarrow reconstitutionChimeric micePlaque sizeClonal expansionMiceMarked increaseCausal roleTET2 deficiencySomatic mutationsHematopoietic cells
1997
CD4-Independent Binding of SIV gp120 to Rhesus CCR5
Martin K, Wyatt R, Farzan M, Choe H, Marcon L, Desjardins E, Robinson J, Sodroski J, Gerard C, Gerard N. CD4-Independent Binding of SIV gp120 to Rhesus CCR5. Science 1997, 278: 1470-1473. PMID: 9367961, DOI: 10.1126/science.278.5342.1470.Peer-Reviewed Original ResearchHIV-1 Entry and Macrophage Inflammatory Protein-1β-mediated Signaling Are Independent Functions of the Chemokine Receptor CCR5*
Farzan M, Choe H, Martin K, Sun Y, Sidelko M, Mackay C, Gerard N, Sodroski J, Gerard C. HIV-1 Entry and Macrophage Inflammatory Protein-1β-mediated Signaling Are Independent Functions of the Chemokine Receptor CCR5*. Journal Of Biological Chemistry 1997, 272: 6854-6857. PMID: 9054370, DOI: 10.1074/jbc.272.11.6854.Peer-Reviewed Original ResearchConceptsHIV-1 entryInflammatory protein-1betaChemokine receptor CCR5Viral entryReceptor CCR5Macrophage inflammatory protein-1βHuman immunodeficiency virus type 1Immunodeficiency virus type 1Ability of CCR5Only viral entrySpecific chemokine receptorsInflammatory protein-1βMacrophage-tropic strainsVirus type 1Wild-type CCR5CCR5 mutantsMCP-1Asymptomatic stageChemokine receptorsHIV-1CCR5Virus life cycleChemokine signalingType 1Target cells