2014
Epigenetic regulation of smooth muscle cell plasticity
Liu R, Leslie KL, Martin KA. Epigenetic regulation of smooth muscle cell plasticity. Biochimica Et Biophysica Acta 2014, 1849: 448-453. PMID: 24937434, PMCID: PMC4552189, DOI: 10.1016/j.bbagrm.2014.06.004.Peer-Reviewed Original ResearchConceptsSMC plasticityEpigenetic regulationSmooth muscle cellsCell plasticitySmooth Muscle Cell PlasticityRegulatory cis elementsCell typesDNA demethylation pathwayLevel of epigeneticsMuscle cell plasticityMature cell typesKey transcription factorMajor cell typesHistone modificationsNovel target moleculesDNA methylationTranscription factorsEnvironmental stressCis elementsPhenotypic statesDemethylation pathwaySMC phenotypeMolecular mechanismsAdult bodyRemarkable plasticity
2007
Regulation of vascular smooth muscle cell differentiation
Rzucidlo E, Martin K, Powell R. Regulation of vascular smooth muscle cell differentiation. Journal Of Vascular Surgery 2007, 45: a25-a32. PMID: 17544021, DOI: 10.1016/j.jvs.2007.03.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsVascular smooth muscle cell differentiationSmooth muscle cell differentiationMuscle cell differentiationCell differentiationPathogenesis of atherosclerosisMajor human diseasesLocal environmental cuesEnvironmental cuesContractile roleIntimal hyperplasiaDifferentiated stateVascular aneurysmsMolecular mechanismsVascular developmentPhenotypic switchingHuman diseasesVessel wallVSMCCritical roleDifferentiationEssential componentHypertensionAsthmaAtherosclerosisHyperplasia