Kartik Pattabiraman, MD/PhD
Assistant Professor in the Child Study CenterDownloadHi-Res Photo
Cards
Appointments
Child Study Center
Primary
Neuroscience
Secondary
Additional Titles
Solnit Integrated Program, Yale Child Study Center
Contact Info
Appointments
Child Study Center
Primary
Neuroscience
Secondary
Additional Titles
Solnit Integrated Program, Yale Child Study Center
Contact Info
Appointments
Child Study Center
Primary
Neuroscience
Secondary
Additional Titles
Solnit Integrated Program, Yale Child Study Center
Contact Info
About
Titles
Assistant Professor in the Child Study Center
Solnit Integrated Program, Yale Child Study Center
Biography
Kartik Pattabiraman is an assistant professor and child psychiatrist at the Yale Child Study Center. He received his M.D. and Ph.D. from University of California, San Francisco. He completed his Ph.D. thesis work in the laboratory of John Rubenstein M.D., Ph.D. Afterward, he completed his clinical training in adult and child psychiatry and his postdoctoral training in the laboratory of Nenad Sestan M.D., Ph.D.
Appointments
Child Study Center
Assistant ProfessorPrimaryNeuroscience
Assistant ProfessorSecondary
Other Departments & Organizations
- Albert J. Solnit Integrated Training Program
- Center for Brain & Mind Health
- Child Study Center
- Interdepartmental Neuroscience Program
- Janeway Society
- Neural Disorders
- Neuroscience
- Neuroscience Research Training Program (NRTP)
- Neuroscience Track
- Wu Tsai Institute
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Medicine
Education & Training
- Alfred J Solnit Integrated Fellowship
- Yale University (2022)
- MD/PhD
- University of California, San Franciso, Neuroscience (2016)
- ScB
- Brown University, Neuroscience (2007)
Research
Overview
Medical Research Interests
Cerebral Cortex; Developmental Disabilities; Embryonic and Fetal Development; Gene Regulatory Networks; Schizophrenia
Public Health Interests
Child/Adolescent Health
ORCID
0000-0002-3924-426X- View Lab Website
Pattabiraman Lab Website
Research at a Glance
Yale Co-Authors
Frequent collaborators of Kartik Pattabiraman's published research.
Publications Timeline
A big-picture view of Kartik Pattabiraman's research output by year.
Research Interests
Research topics Kartik Pattabiraman is interested in exploring.
Nenad Sestan, MD, PhD
Suel-Kee Kim
Victor Luria, PhD
Xiaojun Xing
11Publications
800Citations
Cerebral Cortex
Gene Regulatory Networks
Publications
Featured Publications
Regulation of prefrontal patterning and connectivity by retinoic acid
Shibata M, Pattabiraman K, Lorente-Galdos B, Andrijevic D, Kim SK, Kaur N, Muchnik SK, Xing X, Santpere G, Sousa AMM, Sestan N. Regulation of prefrontal patterning and connectivity by retinoic acid. Nature 2021, 598: 483-488. PMID: 34599305, PMCID: PMC9018119, DOI: 10.1038/s41586-021-03953-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPrefrontal cortexRetinoic acidGranular layer 4Neocortex of humansRetinoic acid signalingCerebral cortexRetinoic acid receptorsMotor cortexMotor areaMediodorsal thalamusFetal developmentCortical expansionAcid receptorsGenetic deletionDendritic spinogenesisLayer 4Synthesizing enzymesCortexAcid signalingNeural developmentMiceCritical roleSignalingThalamusSpinogenesis
2024
15.3 Connecting ASD Risk Genes to Circuits: Multi-Level Characterization of the Cortical Subplate
Pattabiraman K. 15.3 Connecting ASD Risk Genes to Circuits: Multi-Level Characterization of the Cortical Subplate. Journal Of The American Academy Of Child & Adolescent Psychiatry 2024, 63: s334. DOI: 10.1016/j.jaac.2024.07.719.Peer-Reviewed Original ResearchTranscriptome-Connectome association from fetal stage to adulthood
Ouyang M, Poddar T, Santpere G, Andrijevic D, Ma S, Pattabiraman K, Gobeske K, Sestan N, Huang H. Transcriptome-Connectome association from fetal stage to adulthood. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2024 DOI: 10.58530/2024/2389.Peer-Reviewed Original Research
2023
Molecular and cellular mechanisms of human cortical connectivity
Luria V, Ma S, Shibata M, Pattabiraman K, Sestan N. Molecular and cellular mechanisms of human cortical connectivity. Current Opinion In Neurobiology 2023, 80: 102699. PMID: 36921362, DOI: 10.1016/j.conb.2023.102699.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2021
Transcriptional network orchestrating regional patterning of cortical progenitors
Ypsilanti AR, Pattabiraman K, Catta-Preta R, Golonzhka O, Lindtner S, Tang K, Jones IR, Abnousi A, Juric I, Hu M, Shen Y, Dickel DE, Visel A, Pennachio LA, Hawrylycz M, Thompson CL, Zeng H, Barozzi I, Nord AS, Rubenstein JL. Transcriptional network orchestrating regional patterning of cortical progenitors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2024795118. PMID: 34921112, PMCID: PMC8713794, DOI: 10.1073/pnas.2024795118.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRegional patterningEnhancer-gene interactionsTranscription factor networkTF ChIP-seqExpression of hundredsCortical progenitorsVentricular zoneRadial glial stem cellsMutant miceEpigenomic marksTF networksDNA accessibilityGenomic programmingTranscriptional networksGlial stem cellsFactor networkChIP-seqStem cellsVZ cellsPatterningProgenitorsEnhancerMouse cortexExpressionCellsHominini-specific regulation of CBLN2 increases prefrontal spinogenesis
Shibata M, Pattabiraman K, Muchnik SK, Kaur N, Morozov YM, Cheng X, Waxman SG, Sestan N. Hominini-specific regulation of CBLN2 increases prefrontal spinogenesis. Nature 2021, 598: 489-494. PMID: 34599306, PMCID: PMC9018127, DOI: 10.1038/s41586-021-03952-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsCalcium-Binding ProteinsDendritesEnhancer Elements, GeneticFemaleHumansIntercellular Signaling Peptides and ProteinsMacacaMental DisordersMiceNerve Tissue ProteinsNervous System DiseasesNeural Cell Adhesion MoleculesPhylogenyPrefrontal CortexPromoter Regions, GeneticSOXD Transcription FactorsTranscriptomeUp-RegulationConceptsCerebellin 2Prefrontal cortexCerebral cortex regionsDendritic spine formationInitiation of synaptogenesisLaminar distributionDendritic spinesNervous systemNeuropsychiatric disordersSpine formationLevel of expressionCortex regionsGenetic humanizationCortical gradientsDisproportionate increaseSpecies differencesNeurexinsSpinogenesisDysfunctionMolecular basisPathogenesisExpressionCortexSynaptogenesisSpine
2020
The evolution of the human brain and disease susceptibility
Pattabiraman K, Muchnik SK, Sestan N. The evolution of the human brain and disease susceptibility. Current Opinion In Genetics & Development 2020, 65: 91-97. PMID: 32629339, DOI: 10.1016/j.gde.2020.05.004.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGene expression patternsField of evolutionDisease risk genesNervous system developmentExtant speciesGene regulationEvolutionary changeExtinct ancestorsExpression patternsGenetic studiesMetabolic processesHuman-specific aspectsRisk genesCell typesHuman biologyEvolutionary perspectiveDisease susceptibilityNeurodegenerative disease riskNeurodegenerative diseasesDifficult hypothesisComplex processGenomicsAncestorEvolutionGenes
2016
Subpallial Enhancer Transgenic Lines: a Data and Tool Resource to Study Transcriptional Regulation of GABAergic Cell Fate
Silberberg SN, Taher L, Lindtner S, Sandberg M, Nord AS, Vogt D, Mckinsey GL, Hoch R, Pattabiraman K, Zhang D, Ferran JL, Rajkovic A, Golonzhka O, Kim C, Zeng H, Puelles L, Visel A, Rubenstein JLR. Subpallial Enhancer Transgenic Lines: a Data and Tool Resource to Study Transcriptional Regulation of GABAergic Cell Fate. Neuron 2016, 92: 59-74. PMID: 27710791, PMCID: PMC5063253, DOI: 10.1016/j.neuron.2016.09.027.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGABAergic cell fateEnhancer activityTranscriptional regulationCell fateNovel molecular mechanismStable transgenic mouse linesTranscriptional circuitryTransgenic linesTranscription factorsTranscriptional mechanismsDifferent enhancer elementsFate mapEnhancer elementsMolecular mechanismsTransgenic mouse lineForebrain developmentDistinct domainsMouse linesRegulationAmygdala neuronsBasal gangliaFateSpecific subtypesMutantsUnique tool
2015
Genomic Perspectives of Transcriptional Regulation in Forebrain Development
Nord AS, Pattabiraman K, Visel A, Rubenstein JL. Genomic Perspectives of Transcriptional Regulation in Forebrain Development. Neuron 2015, 85: 27-47. PMID: 25569346, PMCID: PMC4438709, DOI: 10.1016/j.neuron.2014.11.011.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCis-acting genomic elementsForebrain developmentGene expression statesGene expression programsAnalysis of chromatinGenomic regulatory mechanismsGenetic circuitryGenomic perspectiveExpression programsGenomic elementsTranscriptional regulationExpression statesHigher-order brain functionsTranscription factorsDNA modificationsGene expressionRegulatory mechanismsHuman neuropsychiatric disordersGenetic defectsCurrent knowledgeChromatinRecent progressEnhancerNeuropsychiatric disordersRegulation
2014
Transcriptional Regulation of Enhancers Active in Protodomains of the Developing Cerebral Cortex
Pattabiraman K, Golonzhka O, Lindtner S, Nord AS, Taher L, Hoch R, Silberberg SN, Zhang D, Chen B, Zeng H, Pennacchio LA, Puelles L, Visel A, Rubenstein JL. Transcriptional Regulation of Enhancers Active in Protodomains of the Developing Cerebral Cortex. Neuron 2014, 82: 989-1003. PMID: 24814534, PMCID: PMC4104757, DOI: 10.1016/j.neuron.2014.04.014.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsBinding SitesCerebral CortexCOUP Transcription Factor IEnhancer Elements, GeneticEye ProteinsGene Expression Regulation, DevelopmentalHippocampusHomeodomain ProteinsHumansMiceMice, TransgenicPaired Box Transcription FactorsPAX6 Transcription FactorPre-B-Cell Leukemia Transcription Factor 1Repressor ProteinsTranscription FactorsTranscription, Genetic
Academic Achievements & Community Involvement
honor Klingenstein Simons Fellowship Awards in Neuroscience
National AwardEsther A. & Joseph Klingenstein FundDetails07/01/2024honor Deeda Blair Research Initiative for Disorders of the Brain Award
National AwardFoundation for the National Institutes of HealthDetails07/01/2024honor Bridge to Independence
National AwardSimons Foundation Autism Research Initiative (SFARI)Details07/01/2022United Stateshonor Career Award for Medical Scientists
National AwardBurroughs Wellcome FundDetails06/27/2022United States
News
News
- June 25, 2024Source: FNIH
Pattabiraman receives award from the Deeda Blair Research Initiative for Disorders of the Brain
- October 11, 2023
Yale Child Study Center Community Celebrates Professional Progression
- June 08, 2023
Yale Child Study Center welcomes 2023 summer interns
- April 03, 2023
2023 Trainee Pilot Research Award Recipients Announced