Featured Publications
Unfolded Protein Response Differentially Modulates the Platelet Phenotype
Jain K, Tyagi T, Du J, Hu X, Patell K, Martin KA, Hwa J. Unfolded Protein Response Differentially Modulates the Platelet Phenotype. Circulation Research 2022, 131: 290-307. PMID: 35862006, PMCID: PMC9357223, DOI: 10.1161/circresaha.121.320530.Peer-Reviewed Original ResearchConceptsUPR pathwayProtein responseMouse plateletsUnfolded protein responseActivation of UPRPlatelet phenotypeTranscriptional regulationGenomic regulationProtein misfoldingAnucleate plateletsProtein aggregationUPR activationPhosphorylation of PLCγ2Chemical chaperonesXBP1 pathwayP38 MAPKPERK pathwayUPRPKCδ activationPlatelet physiologyActivation pathwayPathwayPhenotypeIRE1α inhibitionSelective induction
2014
P436Role of myocardial proteostasis in hypoxic tolerance: effect of chemical chaperones and er stress inducers
Jain K, Ganju L, Suryakumar G. P436Role of myocardial proteostasis in hypoxic tolerance: effect of chemical chaperones and er stress inducers. Cardiovascular Research 2014, 103: s80-s80. DOI: 10.1093/cvr/cvu091.115.Peer-Reviewed Original ResearchChemical chaperonesProtein modificationER stressStress inducersHypoxic toleranceRole of proteinsOxidative protein modificationsER stress inducersHeat shock protein expressionStress toleranceProtein homeostasisInhibition of apoptosisProtein misfoldingShock protein expressionEnvironmental stressHarsh environmental conditionsExpression analysisER stress activationChaperonesUPR markersGreater protein oxidationER stress markersBiochemical assaysEnvironmental conditionsProtein oxidation