2023
Association of flooding exposure with cause-specific mortality in North Carolina, United States
Ban J, Sutton C, Ma Y, Lin C, Chen K. Association of flooding exposure with cause-specific mortality in North Carolina, United States. Nature Water 2023, 1: 1027-1034. DOI: 10.1038/s44221-023-00167-5.Peer-Reviewed Original ResearchCause-specific mortalityRelative riskAssociated with mortality riskAssociated with higher relative riskCounty-level estimatesTime series designTwo-stage time-series designHigher relative riskNorth CarolinaOlder adultsSeries designDeaths per yearMortality riskMental disordersUnited StatesAccidental mortalityNon-accidentalRisk increaseTotal deathHealth impactsCardiovascular diseaseCounty levelAssociationMortalityRespiratory diseaseRacial/ethnic disparities in PM2.5-attributable cardiovascular mortality burden in the United States
Ma Y, Zang E, Opara I, Lu Y, Krumholz H, Chen K. Racial/ethnic disparities in PM2.5-attributable cardiovascular mortality burden in the United States. Nature Human Behaviour 2023, 7: 2074-2083. PMID: 37653149, PMCID: PMC10901568, DOI: 10.1038/s41562-023-01694-7.Peer-Reviewed Original ResearchConceptsNon-Hispanic White peopleCVD deathMortality burdenNon-Hispanic black peopleCardiovascular disease mortality ratesDisease mortality ratesNon-Hispanic blacksRace/ethnicityMortality rateLong-term exposureWhite peopleEthnic disparitiesHealth benefitsHispanic peopleSignificant differencesBurdenDeathUS countiesEthnic groupsAbsolute disparityAssociationExposureEthnic minoritiesDisparitiesAmbient fine particulate matter (PM2.5) concentrations
2020
Hourly Exposure to Ultrafine Particle Metrics and the Onset of Myocardial Infarction in Augsburg, Germany
Chen K, Schneider A, Cyrys J, Wolf K, Meisinger C, Heier M, von Scheidt W, Kuch B, Pitz M, Peters A, Breitner S, Group F. Hourly Exposure to Ultrafine Particle Metrics and the Onset of Myocardial Infarction in Augsburg, Germany. Environmental Health Perspectives 2020, 128: 017003. PMID: 31939685, PMCID: PMC7015564, DOI: 10.1289/ehp5478.Peer-Reviewed Original ResearchConceptsMyocardial infarctionMI casesTime-stratified case-crossover analysisConditional logistic regressionInterquartile range increaseCase-crossover analysisTwo-pollutant modelsMI registryEpidemiological evidenceDifferent particle metricsCardiovascular diseaseMyocardial infractionSimilar associationLogistic regressionHourly air pollutionParticle metricsEffect estimatesHealth effectsExposure metricsIndependent effectsTransient exposureInfarctionAssociationExposureAerodynamic diameter
2019
Temporal variations in the triggering of myocardial infarction by air temperature in Augsburg, Germany, 1987–2014
Chen K, Breitner S, Wolf K, Hampel R, Meisinger C, Heier M, von Scheidt W, Kuch B, Peters A, Schneider A, Peters A, Schulz H, Schwettmann L, Leidl R, Heier M, Strauch K. Temporal variations in the triggering of myocardial infarction by air temperature in Augsburg, Germany, 1987–2014. European Heart Journal 2019, 40: 1600-1608. PMID: 30859207, DOI: 10.1093/eurheartj/ehz116.Peer-Reviewed Original ResearchConceptsMyocardial infarctionMI riskCases of MIRisk of MITime-stratified case-crossover analysisPopulation susceptibilityCase-crossover analysisArea of AugsburgCoronary deathDiabetes mellitusNon-significant declineSubgroup analysisRelative riskLag non-linear modelShort-term exposureMI eventsEnvironmental triggersInfarctionRiskFuture studiesSocioeconomic settingsAssociationExposureSusceptibility
2018
Two-way effect modifications of air pollution and air temperature on total natural and cardiovascular mortality in eight European urban areas
Chen K, Wolf K, Breitner S, Gasparrini A, Stafoggia M, Samoli E, Andersen ZJ, Bero-Bedada G, Bellander T, Hennig F, Jacquemin B, Pekkanen J, Hampel R, Cyrys J, Peters A, Schneider A, Group U. Two-way effect modifications of air pollution and air temperature on total natural and cardiovascular mortality in eight European urban areas. Environment International 2018, 116: 186-196. PMID: 29689465, DOI: 10.1016/j.envint.2018.04.021.Peer-Reviewed Original ResearchConceptsCardiovascular mortalityAmbient air pollutionShort-term associationsTemperature-mortality associationCity-specific effect estimatesEffect modificationHigh air pollutionMortality riskEpidemiological studiesInfluenza epidemicsMortalityEffect estimatesMortality effectsAir pollutionDaily mortalityAssociationDaysAir pollution levelsDistributed lag
2014
Influence of heat wave definitions to the added effect of heat waves on daily mortality in Nanjing, China
Chen K, Bi J, Chen J, Chen X, Huang L, Zhou L. Influence of heat wave definitions to the added effect of heat waves on daily mortality in Nanjing, China. The Science Of The Total Environment 2014, 506: 18-25. PMID: 25460935, DOI: 10.1016/j.scitotenv.2014.10.092.Peer-Reviewed Original ResearchConceptsDifferent heat wave definitionsDisease mortalityChronic obstructive pulmonary disease (COPD) mortalityIschemic heart disease mortalityLag day 2Heart disease mortalityBurden of diseaseCause-specific mortalityDaily mortalityCardiovascular mortalityStroke mortalityEffect modificationHeat wave definitionsStratified analysisRespiratory mortalityDay 2Total mortalityMortalityConsecutive daysHeat warning systemsLower educationDaysAssociationGood model fitCritical role