NQO1 inhibits proteasome-mediated degradation of HIF-1α
Oh ET, Kim JW, Kim JM, Kim SJ, Lee JS, Hong SS, Goodwin J, Ruthenborg RJ, Jung MG, Lee HJ, Lee CH, Park ES, Kim C, Park HJ. NQO1 inhibits proteasome-mediated degradation of HIF-1α. Nature Communications 2016, 7: 13593. PMID: 27966538, PMCID: PMC5171868, DOI: 10.1038/ncomms13593.Peer-Reviewed Original ResearchConceptsHIF-1αColorectal cancer patient survivalNQO1 expression levelsBreast cancer cell linesOverexpression of NQO1HIF-1α expressionCancer patient survivalPro-tumorigenic capacityNQO1 knockdownCancer cell linesPro-tumorigenic functionsPatient survivalPoor prognosisHIF-1α stabilityFunction of NQO1Oxygen-dependent domainHuman colorectalMalignant progressionTumor growthNQO1CancerHIF-1Human cancersMaster transcription factorExpression levels