2024
Impact of acute kidney injury response on survival and liver transplant rates in hospitalized patients with cirrhosis awaiting liver transplantation: Results from the HRS-HARMONY consortium
Li X, Ouyang T, Belcher J, Patidar K, Cullaro G, Asrani S, Wadei H, Simonetto D, Regner K, Dageforde L, Przybyszewski E, Wilechansky R, Sharma P, Ufere N, Duarte-Rojo A, Wahid N, Orman E, St. Hillien S, Robinson J, Chung R, Allegretti A, collaborative I. Impact of acute kidney injury response on survival and liver transplant rates in hospitalized patients with cirrhosis awaiting liver transplantation: Results from the HRS-HARMONY consortium. Liver Transplantation 2024, 30: 1106-1115. PMID: 39073567, DOI: 10.1097/lvt.0000000000000445.Peer-Reviewed Original ResearchAKI responseAcute kidney injuryTransplant-free survivalLiver transplantationLT ratesCirrhosis patientsNon-respondersTime of liver transplantationCourse of hospitalized patientsNo responseRetrospective multicenter studyMELD-Na scoreResponse to therapyResponse to treatmentLiver transplant ratesRate of LTOverall survivalMulticenter studyKidney injuryCirrhosis etiologyCirrhosisHospitalized patientsTransplantationPatientsInjury responseOutcomes of patients with alcohol‐associated hepatitis and acute kidney injury – Results from the HRS Harmony Consortium
T. A, Allegretti A, Cullaro G, Ouyang T, Asrani S, Chung R, Przybyszewski E, Wilechansky R, Robinson J, Sharma P, Simonetto D, Jalal P, Orman E, Wadei H, St. Hillien S, Saly D, Ufere N, Dageforde L, Regner K, Belcher J, Patidar K, Consortium F. Outcomes of patients with alcohol‐associated hepatitis and acute kidney injury – Results from the HRS Harmony Consortium. Alimentary Pharmacology & Therapeutics 2024, 60: 778-786. PMID: 39010302, PMCID: PMC11349455, DOI: 10.1111/apt.18159.Peer-Reviewed Original ResearchAlcohol-associated hepatitisAcute kidney injuryAcute kidney injury phenotypesHepatorenal syndromeMELD-NaDevelopment of acute kidney injuryCumulative incidence of deathConsecutive adult patientsOutcomes of patientsAlcohol Abuse and Alcoholism (NIAAANon-AH groupRenal replacement therapyPresence of AHAcute tubular necrosisRetrospective cohort studyPredictors of mortalityIncidence of deathAKI stageClinical courseReplacement therapyAdult patientsKidney injuryCumulative incidencePoor prognosisTubular necrosisAcute kidney injury in patients with cirrhosis: Acute Disease Quality Initiative (ADQI) and International Club of Ascites (ICA) joint multidisciplinary consensus meeting
Nadim M, Kellum J, Forni L, Francoz C, Asrani S, Ostermann M, Allegretti A, Neyra J, Olson J, Piano S, VanWagner L, Verna E, Akcan-Arikan A, Angeli P, Belcher J, Biggins S, Deep A, Garcia-Tsao G, Genyk Y, Gines P, Kamath P, Kane-Gill S, Kaushik M, Lumlertgul N, Macedo E, Maiwall R, Marciano S, Pichler R, Ronco C, Tandon P, Velez J, Mehta R, Durand F. Acute kidney injury in patients with cirrhosis: Acute Disease Quality Initiative (ADQI) and International Club of Ascites (ICA) joint multidisciplinary consensus meeting. Journal Of Hepatology 2024, 81: 163-183. PMID: 38527522, PMCID: PMC11193657, DOI: 10.1016/j.jhep.2024.03.031.Peer-Reviewed Original ResearchAcute Disease Quality InitiativeInternational Club of AscitesAcute kidney injuryHRS-AKIQuality InitiativeHepatorenal syndromePost-discharge follow-upKidney injuryMultidisciplinary consensus meetingRisk of progression to chronic kidney diseaseProgression to chronic kidney diseasePhenotypes of acute kidney injuryFollow-up of patientsBridge to liver transplantationIncreased in-hospital morbidityIn-hospital morbidityPost-discharge follow-up of patientsChronic kidney diseaseMortality riskConsensus meetingInternational ClubCurative optionSplanchnic vasoconstrictorsAdvanced cirrhosisLiver transplantationHepatorenal Syndrome Type 1: Diagnosis and Treatment
Belcher J. Hepatorenal Syndrome Type 1: Diagnosis and Treatment. Advances In Kidney Disease And Health 2024, 31: 100-110. PMID: 38649214, DOI: 10.1053/j.akdh.2023.05.001.Peer-Reviewed Original ResearchConceptsAcute kidney injuryHepatorenal syndromeKidney injuryFunctional acute kidney injuryUrinary biomarkers of kidney injuryAssociated with significant morbidityFractional excretion of sodiumNeutrophil gelatinase-associated lipocalinDiagnostic criteriaBiomarkers of kidney injuryMultiple urinary biomarkersOptimal dosing strategiesExcretion of sodiumPoint-of-care ultrasoundAccurate differential diagnosisAnalog of vasopressinSets of diagnostic criteriaAdvanced cirrhosisAlbumin administrationSignificant morbidityVolume resuscitationTherapeutic optionsDosing strategiesFractional excretionDifferential diagnosis
2023
Incidence and outcomes of acute kidney injury including hepatorenal syndrome in hospitalized patients with cirrhosis in the US
Patidar K, Belcher J, Regner K, St. Hillien S, Simonetto D, Asrani S, Neyra J, Sharma P, Velez J, Wadei H, Nadim M, Chung R, Seethapathy R, Parada X, Ouyang T, Ufere N, Robinson J, Diaz P, Wilechansky R, Przybyszewski E, Smith T, Ali A, Orman E, Schulz P, Siddiqui S, Shabbir R, Liu L, Cama-Olivares A, Flannery A, Baker M, Gunasekaran D, Aswine A, Issa R, Li J, Verma S, Chalmers D, Varghese V, Lam W, Mohamed M, Kovacic R, Gaddy A, Attieh R, Cortes P, Semnani S, Wang L, Khemichian S, Allegretti A, consortium F. Incidence and outcomes of acute kidney injury including hepatorenal syndrome in hospitalized patients with cirrhosis in the US. Journal Of Hepatology 2023, 79: 1408-1417. PMID: 37517455, PMCID: PMC10807505, DOI: 10.1016/j.jhep.2023.07.010.Peer-Reviewed Original ResearchConceptsEtiology of AKIHRS-AKISubdistribution hazard ratiosHepatorenal syndromePrerenal AKIKidney injuryHigh morbidityIncidence ratePractice patternsSimilar outcomesHigher AKI stageAcute kidney injuryRetrospective cohort studyAcute tubular necrosisConsecutive adult patientsEtiology of injuryAKI stageAKI definitionLiver transplantAdult patientsCohort studyHazard ratioSevere complicationsTubular necrosisComplete responseHepatorenal Syndrome Pathophysiology, Diagnosis, and Treatment
Belcher J. Hepatorenal Syndrome Pathophysiology, Diagnosis, and Treatment. Medical Clinics Of North America 2023, 107: 781-792. PMID: 37258014, DOI: 10.1016/j.mcna.2023.03.009.Peer-Reviewed Original ResearchConceptsAcute kidney injuryHepatorenal syndromeCombination of midodrineFirst-line standardPooling of bloodAnalog of vasopressinIntravenous albuminKidney injuryLiver transplantationVasoconstrictor agentsDefinitive treatmentPathophysiologic cascadeSplanchnic systemSyndrome pathophysiologyArterial volumeTreatmentTerlipressinCirrhosisMidodrineOctreotidePatientsTransplantationPathophysiologySyndromeInjury
2021
Terlipressin and the Treatment of Hepatorenal Syndrome: How the CONFIRM Trial Moves the Story Forward
Belcher JM, Parada XV, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Sharma P, Regner KR, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT, Allegretti AS, Investigators H. Terlipressin and the Treatment of Hepatorenal Syndrome: How the CONFIRM Trial Moves the Story Forward. American Journal Of Kidney Diseases 2021, 79: 737-745. PMID: 34606933, DOI: 10.1053/j.ajkd.2021.08.016.Peer-Reviewed Original ResearchConceptsAcute kidney injuryHepatorenal syndromeRespiratory adverse eventsPrimary end pointFirst-line therapyMean arterial pressureSympathetic nervous systemSynthetic vasopressin analogueAdvanced cirrhosisHRS reversalAldosterone systemKidney injuryLack of evidenceAdverse eventsMortality benefitPortal pressureArterial pressureFulminant formSplanchnic systemSignificant morbidityRenal vasculatureVasodilatory substancesApparent increased rateTerlipressinCONFIRM trialsUrinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study
Allegretti AS, Parada XV, Endres P, Zhao S, Krinsky S, St. Hillien SA, Kalim S, Nigwekar SU, Flood JG, Nixon A, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Regner KR, Belcher JM, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT. Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study. Clinical And Translational Gastroenterology 2021, 12: e00359. PMID: 33979307, PMCID: PMC8116001, DOI: 10.14309/ctg.0000000000000359.Peer-Reviewed Original ResearchConceptsNeutrophil gelatinase-associated lipocalinUrinary neutrophil gelatinase-associated lipocalinAcute kidney injuryAcute tubular necrosisPrerenal acute kidney injuryHepatorenal syndromeKidney injuryC-statisticManagement of AKITypes of AKIEnd-stage liver disease (MELD) scoreTransplant-free survivalLiver Disease scoreMedian serum creatinineGelatinase-associated lipocalinPrediction of mortalityNet reclassification indexDiscrimination incrementProspective cohortSerum creatinineTubular necrosisProspective studyReclassification indexUnadjusted analysesPrognostic marker
2019
47 Acute Kidney Injury Diagnostics and Biomarkers
Belcher J, Parikh C. 47 Acute Kidney Injury Diagnostics and Biomarkers. 2019, 713-724.e5. DOI: 10.1016/b978-0-323-52978-5.00047-1.Peer-Reviewed Original ResearchAcute kidney injuryKidney injuryUrine outputPrognosis of AKICommon clinical conditionLong-term outcomesAppropriate clinical trialsPotential therapeutic efficacyNew therapeutic approachesMultiple potential therapiesFrank injurySerum creatinineAcute settingInjury biomarkersHigh morbidityClinical trialsDifferential diagnosisClinical conditionsEarly diagnosisTherapeutic approachesPotential therapyAnimal modelsPromising biomarkerSuch biomarkersTherapeutic efficacy
2018
Acute Kidney Injury and Liver Disease: Incidence, Pathophysiology, Prevention/Treatment, and Outcomes
Belcher J, Parikh C. Acute Kidney Injury and Liver Disease: Incidence, Pathophysiology, Prevention/Treatment, and Outcomes. 2018, 113-131. DOI: 10.1007/978-1-4939-8628-6_7.Peer-Reviewed Original ResearchAcute kidney injuryAcute tubular necrosisHepatorenal syndromeKidney injuryDefinition of AKIRecent consensus criteriaStructural kidney injurySpontaneous bacterial peritonitisPortal hypertension resultsPrevention/treatmentMultiple urinary biomarkersAKI etiologyCreatinine cutoffRenal hypoperfusionGastrointestinal bleedingPrerenal azotemiaRenal functionSecondary insultsTubular necrosisBacterial peritonitisFractional excretionHypertension resultsPathophysiologic cascadeCommon etiologyLiver disease
2016
Urine Interleukin 18 and Lipocalin 2 Are Biomarkers of Acute Tubular Necrosis in Patients With Cirrhosis: A Systematic Review and Meta-analysis
Puthumana J, Ariza X, Belcher JM, Graupera I, Ginès P, Parikh CR. Urine Interleukin 18 and Lipocalin 2 Are Biomarkers of Acute Tubular Necrosis in Patients With Cirrhosis: A Systematic Review and Meta-analysis. Clinical Gastroenterology And Hepatology 2016, 15: 1003-1013.e3. PMID: 28013112, PMCID: PMC5474196, DOI: 10.1016/j.cgh.2016.11.035.Peer-Reviewed Original ResearchConceptsNeutrophil gelatinase-associated lipocalinAcute tubular necrosisUrine levelsUrine biomarkersSystematic reviewKidney impairmentKidney injuryTubular necrosisLipocalin-2Development of ATNAUC valuesEtiology of AKIUrine interleukin-18Acute kidney injuryGelatinase-associated lipocalinShort-term mortalityLogistic mixed-effects modelsHepatorenal syndromeCause mortalityPrerenal azotemiaCommon complicationInterleukin-18Prospective studyPatient outcomesCommon causeA Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury
Zhao B, Lu Q, Cheng Y, Belcher JM, Siew ED, Leaf DE, Body SC, Fox AA, Waikar SS, Collard CD, Thiessen-Philbrook H, Ikizler TA, Ware LB, Edelstein CL, Garg AX, Choi M, Schaub JA, Zhao H, Lifton RP, Parikh CR. A Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury. American Journal Of Respiratory And Critical Care Medicine 2016, 195: 482-490. PMID: 27576016, PMCID: PMC5378420, DOI: 10.1164/rccm.201603-0518oc.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultAgedApolipoprotein L1ApolipoproteinsBiomarkersCardiac Surgical ProceduresCase-Control StudiesCritical IllnessFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansIntensive Care UnitsInterferon Regulatory Factor-2Lipoproteins, HDLMaleMiddle AgedPolymorphism, Single NucleotidePostoperative ComplicationsRisk FactorsStatistics, NonparametricT-Box Domain ProteinsConceptsAcute kidney injuryGenome-wide association studiesSingle nucleotide polymorphismsKidney injuryGenetic lociAssociation studiesExploratory genome-wide association studyAcute kidney injury casesHospital acute kidney injuryCommon genetic variantsIndependent lociGene TBX1Chromosome 4Novel pathwayCritical illnessCardiac surgerySevere complicationsLociPatient populationTherapeutic advancesGenetic variantsGenotype imputationInjury casesExpedite recoveryInjury
2015
Acute Kidney Injury in Liver Disease: Role of Biomarkers
Belcher JM. Acute Kidney Injury in Liver Disease: Role of Biomarkers. Advances In Kidney Disease And Health 2015, 22: 368-375. PMID: 26311598, DOI: 10.1053/j.ackd.2015.06.009.BooksConceptsAcute kidney injuryEtiology of AKINeutrophil gelatinase-associated lipocalinAcute tubular necrosisGelatinase-associated lipocalinHepatorenal syndromeKidney injuryPrerenal azotemiaTubular necrosisFractional excretionInterleukin-18Urinary neutrophil gelatinase-associated lipocalinProgression of AKIKidney tubular injurySetting of cirrhosisOverall poor outcomeRole of biomarkersStandard diagnostic toolAdvanced cirrhosisAKI etiologyCommon complicationTubular injuryCommon etiologyLiver diseasePoor outcome
2014
Urinary Biomarkers and Progression of AKI in Patients with Cirrhosis
Belcher JM, Garcia-Tsao G, Sanyal AJ, Thiessen-Philbrook H, Peixoto AJ, Perazella MA, Ansari N, Lim J, Coca SG, Parikh CR. Urinary Biomarkers and Progression of AKI in Patients with Cirrhosis. Clinical Journal Of The American Society Of Nephrology 2014, 9: 1857-1867. PMID: 25183658, PMCID: PMC4220770, DOI: 10.2215/cjn.09430913.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAcute-Phase ProteinsAdultAgedAlbuminuriaBiomarkersDisease ProgressionFatty Acid-Binding ProteinsFemaleHepatitis A Virus Cellular Receptor 1Hospital MortalityHumansInterleukin-18Lipocalin-2LipocalinsLiver CirrhosisMaleMembrane GlycoproteinsMiddle AgedPredictive Value of TestsProspective StudiesProto-Oncogene ProteinsReceptors, VirusSodiumConceptsProgression of AKIAKI progressionIL-18Urinary biomarkersHospital mortalityKIM-1End-stage liver disease (MELD) scoreL-FABPStage liver disease scoreNeutrophil gelatinase-associated lipocalinAKI Network criteriaLiver Disease scoreProspective cohort studyGelatinase-associated lipocalinNet reclassification indexUnited States medical centersKey clinical variablesRobust clinical modelKidney injuryCohort studySevere complicationsLiver cirrhosisRisk stratificationClinical variablesMarker levelsIncidence, Trends, and Diagnosis of Perioperative Acute Kidney Injury
Belcher J, Parikh C. Incidence, Trends, and Diagnosis of Perioperative Acute Kidney Injury. 2014, 3-14. DOI: 10.1007/978-1-4939-1273-5_1.Peer-Reviewed Original ResearchAcute kidney injuryAcute Kidney Injury NetworkKidney injuryKidney diseaseIncidence of AKIUnderstanding of AKIPerioperative acute kidney injuryPostoperative acute kidney injuryEnd-stage kidney diseaseException of patientsSolid organ transplantsIntensive care unitAKI incidenceAKI definitionAKI ratesNoncardiac surgeryPostoperative patientsCardiac surgeryCare unitEpidemiologic studiesOrgan transplantsMortality rateGlobal outcomeIncidenceInjuryKidney biomarkers and differential diagnosis of patients with cirrhosis and acute kidney injury
Belcher JM, Sanyal AJ, Peixoto AJ, Perazella MA, Lim J, Thiessen‐Philbrook H, Ansari N, Coca SG, Garcia‐Tsao G, Parikh CR, Consortium F. Kidney biomarkers and differential diagnosis of patients with cirrhosis and acute kidney injury. Hepatology 2014, 60: 622-632. PMID: 24375576, PMCID: PMC4065642, DOI: 10.1002/hep.26980.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAcute-Phase ProteinsAdultAgedAlbuminuriaBiomarkersCreatinineDiagnosis, DifferentialFatty Acid-Binding ProteinsFemaleGlomerular Filtration RateHepatitis A Virus Cellular Receptor 1HumansInterleukin-18KidneyLipocalin-2LipocalinsLiver CirrhosisMaleMembrane GlycoproteinsMiddle AgedProspective StudiesProto-Oncogene ProteinsReceptors, VirusSodiumConceptsAcute kidney injuryAcute tubular necrosisKidney injury molecule-1Neutrophil gelatinase-associated lipocalinHepatorenal syndromePrerenal azotemiaKidney injuryDifferential diagnosisUrinary biomarkersEtiology of AKIProgressive acute kidney injuryLiver-type fatty acidOptimal diagnostic cutoffInjury molecule-1Prospective cohort studyGelatinase-associated lipocalinAccurate differential diagnosisClinical decision makingNumber of biomarkersCohort studyTubular necrosisFractional excretionCommon etiologyInterleukin-18Kidney biomarkersEarly Trends in Cystatin C and Outcomes in Patients with Cirrhosis and Acute Kidney Injury
Belcher JM, Sanyal AJ, Garcia-Tsao G, Ansari N, Coca SG, Shlipak MG, Parikh CR. Early Trends in Cystatin C and Outcomes in Patients with Cirrhosis and Acute Kidney Injury. International Journal Of Nephrology 2014, 2014: 708585. PMID: 24757564, PMCID: PMC3976933, DOI: 10.1155/2014/708585.Peer-Reviewed Original ResearchAcute kidney injuryKidney injuryGlomerular filtrationCystatin CCourse of AKIOnset of AKIProgression of AKIProspective multicenter studyEventual dialysisRenal dysfunctionSerum creatinineSevere complicationsComposite endpointPrimary outcomeMulticenter studyAdverse outcomesMore rapid identificationCystatin levelsWeight cysteine proteinase inhibitorCirrhosisCreatininePatientsMultivariate analysisAccurate markerReference group
2013
Acute Kidney Injury in Patients With Cirrhosis: Perils and Promise
Belcher JM, Parikh CR, Garcia–Tsao G. Acute Kidney Injury in Patients With Cirrhosis: Perils and Promise. Clinical Gastroenterology And Hepatology 2013, 11: 1550-1558. PMID: 23583467, PMCID: PMC3840046, DOI: 10.1016/j.cgh.2013.03.018.Commentaries, Editorials and LettersConceptsCreatinine levelsSodium levelsRenal Disease Study equationPacked red blood cellsTotal serum bilirubin levelsAcute kidney injurySerum creatinine levelsMental status changesRenal tubular epithelial cellsSerum sodium levelsChronic liver diseaseGlomerular filtration rateInternational normalization ratioModification of DietIntensive care unitUrine sodium levelSerum bilirubin levelsFresh frozen plasmaChronic alcohol abuseTubular epithelial cellsHepatitis CKidney injuryRed blood cellsBlood pressureFractional excretion
2012
Association of AKI With mortality and complications in hospitalized patients with cirrhosis
Belcher JM, Garcia‐Tsao G, Sanyal AJ, Bhogal H, Lim JK, Ansari N, Coca SG, Parikh CR, Consortium F. Association of AKI With mortality and complications in hospitalized patients with cirrhosis. Hepatology 2012, 57: 753-762. PMID: 22454364, PMCID: PMC3390443, DOI: 10.1002/hep.25735.Peer-Reviewed Original ResearchConceptsAcute kidney injuryAcute Kidney Injury Network definitionAssociation of AKIDefinition of AKISeverity of AKIProgression of AKIProspective observational cohort studyAKIN stage 1Baseline renal functionObservational cohort studyIncidence of mortalityAKI criteriaAKI severityAKI stageAKIN criteriaAKIN stageHospital mortalityKidney injuryCohort studyDevastating complicationRenal functionHospitalized patientsImproved outcomesEarly diagnosisTimely treatment
2011
Clinical Applications of Biomarkers for Acute Kidney Injury
Belcher JM, Edelstein CL, Parikh CR. Clinical Applications of Biomarkers for Acute Kidney Injury. American Journal Of Kidney Diseases 2011, 57: 930-940. PMID: 21411200, DOI: 10.1053/j.ajkd.2010.11.032.BooksConceptsDiagnosis of AKIAcute kidney injurySerum creatinine levelsKidney injuryCreatinine levelsIL-18Multiple novel biomarkersProspective trial designUtility of biomarkersAdequate poweringSuccessful human trialsInterleukin-18Kidney functionNovel therapiesDifferential diagnosisHuman trialsNovel biomarkersTrial designAnimal studiesTherapeutic efficacyInjuryDiagnosisEarly detectionBiomarkersPotential role