Automated Baseline Fluorodeoxyglucose-Positron Emission Tomography Imaging and High BCL2 Expression Provide Orthogonal Prognostic Value in Predicting High-Risk De Novo Diffuse Large B-Cell Lymphoma Patients
Jemaa S, Tracy S, Bottos A, de Crespigny A, Bengtsson T, Nielsen T, Paulson J. Automated Baseline Fluorodeoxyglucose-Positron Emission Tomography Imaging and High BCL2 Expression Provide Orthogonal Prognostic Value in Predicting High-Risk De Novo Diffuse Large B-Cell Lymphoma Patients. Blood 2020, 136: 8-9. DOI: 10.1182/blood-2020-134780.Peer-Reviewed Original ResearchDiffuse large B-cell lymphomaDiffuse large B-cell lymphoma patientsCurrent equity holderInternational Prognostic IndexTotal metabolic tumor volumeFluorodeoxyglucose-positron emission tomographyF Hoffmann-La RocheArea under the receiver operating characteristic curveR-CHOPPrognostic valueClinical featuresFluorodeoxyglucose-positron emission tomography imagingBCL2 expressionAssociated with reduced PFSInternational Prognostic Index categoryPrognostic value of Bcl2F. Hoffmann-La RocheB-cell lymphoma patientsLarge B-cell lymphomaCell of origin (COOMultivariable Cox-pH modelsPrognostic modelUnivariate Cox proportional hazardsBaseline imaging featuresMetabolic tumor volumeRisk Profiling of Relapsed/Refractory Diffuse Large B-Cell Lymphoma Patients By Measuring Circulating Tumor DNA
Herrera A, Tracy S, Croft B, Opat S, Ray J, Musick L, Paulson J, Sehn L, Jiang Y. Risk Profiling of Relapsed/Refractory Diffuse Large B-Cell Lymphoma Patients By Measuring Circulating Tumor DNA. Blood 2020, 136: 23-25. DOI: 10.1182/blood-2020-136645.Peer-Reviewed Original ResearchProgression-free survivalCirculating tumor DNACurrent equity holderInternational Prognostic IndexEntity's Board of DirectorsDetect circulating tumor DNABaseline ctDNA levelCtDNA levelsOverall survivalR/R DLBCLHazard ratioPrognostic factorsHigh riskTumor DNARefractory diffuse large B-cell lymphomaDiffuse large B-cell lymphoma patientsDiffuse large B-cell lymphomaMeasuring circulating tumor DNASource of germline DNACirculating tumor DNA levelsB-cell lymphoma patientsLarge B-cell lymphomaLactate dehydrogenaseEarly identification of patientsFirst-line setting