Genetic Variation in the Mitochondrial Glycerol‐3‐Phosphate Acyltransferase Is Associated With Liver Injury
Hakim A, Moll M, Brancale J, Liu J, Lasky‐Su J, Silverman EK, Vilarinho S, Jiang ZG, Pita‐Juárez Y, Vlachos IS, Zhang X, Åberg F, Afdhal NH, Hobbs BD, Cho MH. Genetic Variation in the Mitochondrial Glycerol‐3‐Phosphate Acyltransferase Is Associated With Liver Injury. Hepatology 2021, 74: 3394-3408. PMID: 34216018, PMCID: PMC8639615, DOI: 10.1002/hep.32038.Peer-Reviewed Original ResearchConceptsAlcohol-associated liver diseaseChronic liver diseaseLiver diseaseLiver injuryAlanine aminotransferaseAspartate aminotransferaseElevated body mass indexLevels of ALTDose-dependent riskFatty liver diseaseBody mass indexAlkaline phosphataseMass General Brigham BiobankWeekly alcohol consumptionGenetic variantsMitochondrial glycerol-3-phosphate acyltransferaseLiver biochemistryHDL cholesterolLDL cholesterolTotal cholesterolMass indexRevision codesVLDL productionGlycerol-3-phosphate acyltransferaseTotal bilirubinGIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension
Drzewiecki K, Choi J, Brancale J, Leney-Greene MA, Sari S, Dalgiç B, Aksu A, Şahin G, Ozen A, Baris S, Karakoc-Aydiner E, Jain D, Kleiner D, Schmalz M, Radhakrishnan K, Zhang J, Hoebe K, Su HC, Pereira JP, Lenardo MJ, Lifton RP, Vilarinho S. GIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension. Journal Of Experimental Medicine 2021, 218: e20201745. PMID: 33956074, PMCID: PMC8105721, DOI: 10.1084/jem.20201745.Peer-Reviewed Original ResearchConceptsLiver sinusoidal endothelial cellsPortal hypertensionEndothelial cell homeostasisHepatic endothelial cellsEndothelial cellsLiver diseaseUnexplained portal hypertensionGlobal health problemSinusoidal endothelial cellsCell homeostasisSingle-cell RNA-sequencing analysisHypertensionMouse modelHealth problemsMice resultsGimap5RNA sequence analysisMajor contributorCritical regulatorDiseaseCellsDamaging mutationsHomeostasisDecompensationMorbidity