2024
Physical space of thirty pediatric intensive care units in the United States of America: a national survey
Karam O, Ahmed A, Bizzarro M, Bogue C, Giuliano J, Collaborative P, Al-Subu A, Bateman S, Berning E, Brown K, Bulut Y, Cheifetz I, Chegondi M, Cholette J, Cowl A, Ceneviva G, Gehlbach J, Hobson M, Kudchadkar S, Labarinas S, Louis C, Miller M, Marinello M, Malone M, Nair A, Nishisaki A, Lowrie L, Rehder K, Rozenfeld R, Schneider J, Sequeira J, Shein S, Stalets E, Taylor J, Yager P. Physical space of thirty pediatric intensive care units in the United States of America: a national survey. Frontiers In Pediatrics 2024, 12: 1473805. PMID: 39359742, PMCID: PMC11445063, DOI: 10.3389/fped.2024.1473805.Peer-Reviewed Original ResearchRoom sizePediatric intensive care unitPhysical spaceConstruction of hospitalsIntensive care unitBuilding yearDesign practiceCare unitBuildings dateRoom designPrivate bathroomsOccupancy rateDouble roomRenovationBathroomCompliant unitsRoom characteristicsAmenitiesDesignConstructionIntermediate care unitCardiac ICUClinical outcomesInterquartile rangeUnit typesKetamine Use in the Intubation of Critically Ill Children with Neurological Indications: A Multicenter Retrospective Analysis.
Loi MV, Lee JH, Huh JW, Mallory P, Napolitano N, Shults J, Krawiec C, Shenoi A, Polikoff L, Al-Subu A, Sanders R Jr, Toal M, Branca A, Glater-Welt L, Ducharme-Crevier L, Breuer R, Parsons S, Harwayne-Gidansky I, Kelly S, Motomura M, Gladen K, Pinto M, Giuliano J Jr, Bysani G, Berkenbosch J, Biagas K, Rehder K, Kasagi M, Lee A, Jung P, Shetty R, Nadkarni V, Nishisaki A, National Emergency Airway Registry for Children (NEAR4KIDS) Investigators, Pediatric Acute Lung Injury, Sepsis Investigators (PALISI) Network. Ketamine Use in the Intubation of Critically Ill Children with Neurological Indications: A Multicenter Retrospective Analysis. Neurocrit Care 2024, 40: 205-214. PMID: 37160847, DOI: 10.1007/s12028-023-01734-0.Peer-Reviewed Original ResearchAdverse Tracheal Intubation Events in Critically Ill Underweight and Obese Children: Retrospective Study of the National Emergency Airway for Children Registry (2013-2020).
Gladen KM, Tellez D, Napolitano N, Edwards LR, Sanders RC Jr, Kojima T, Malone MP, Shults J, Krawiec C, Ambati S, McCarthy R, Branca A, Polikoff LA, Jung P, Parsons SJ, Mallory PP, Komeswaran K, Page-Goertz C, Toal MC, Bysani GK, Meyer K, Chiusolo F, Glater-Welt LB, Al-Subu A, Biagas K, Hau Lee J, Miksa M, Giuliano JS Jr, Kierys KL, Talukdar AM, DeRusso M, Cucharme-Crevier L, Adu-Arko M, Shenoi AN, Kimura D, Flottman M, Gangu S, Freeman AD, Piehl MD, Nuthall GA, Tarquinio KM, Harwayne-Gidansky I, Hasegawa T, Rescoe ES, Breuer RK, Kasagi M, Nadkarni VM, Nishisaki A, National Emergency Airway Registry for Children (NEAR4KIDS) and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI). Adverse Tracheal Intubation Events in Critically Ill Underweight and Obese Children: Retrospective Study of the National Emergency Airway for Children Registry (2013-2020). Pediatr Crit Care Med 2024, 25: 147-158. PMID: 37909825, DOI: 10.1097/PCC.0000000000003387.Peer-Reviewed Original ResearchTracheal Intubation by Advanced Practice Registered Nurses in Pediatric Critical Care: Retrospective Study From the National Emergency Airway for Children Registry (2015-2019).
Van Damme DM, McRae EM, Irving SY, Kelly SP, Tarquinio KM, Giuliano JS Jr, Ruppe MD, Kierys KL, Breuer RK, Parsons SJ, Mallory PP, Shenoi AN, Swain KA, Polikoff LA, Lee A, Adu-Darko MA, Napolitano N, Shults J, Nishisaki A, Berkenbosch JW, National Emergency Airway Registry for Children (NEAR4KIDS) and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI). Tracheal Intubation by Advanced Practice Registered Nurses in Pediatric Critical Care: Retrospective Study From the National Emergency Airway for Children Registry (2015-2019). Pediatr Crit Care Med 2024, 25: 139-146. PMID: 37882620, DOI: 10.1097/PCC.0000000000003386.Peer-Reviewed Original ResearchSafety of primary nasotracheal intubation in the pediatric intensive care unit (PICU).
Ducharme-Crevier L, Furlong-Dillard J, Jung P, Chiusolo F, Malone MP, Ambati S, Parsons SJ, Krawiec C, Al-Subu A, Polikoff LA, Napolitano N, Tarquinio KM, Shenoi A, Talukdar A, Mallory PP, Giuliano JS Jr, Breuer RK, Kierys K, Kelly SP, Motomura M, Sanders RC Jr, Freeman A, Nagai Y, Glater-Welt LB, Wilson J, Loi M, Adu-Darko M, Shults J, Nadkarni V, Emeriaud G, Nishisaki A, National Emergency Airway Registry for Children (NEAR4KIDS), Pediatric Acute Lung Injury, Sepsis Investigators (PALISI) Network. Safety of primary nasotracheal intubation in the pediatric intensive care unit (PICU). Intensive Care Med Paediatr Neonatal 2024, 2: 7. PMID: 38404646, DOI: 10.1007/s44253-024-00035-4.Peer-Reviewed Original Research
2023
Implementation of Video Laryngoscope-Assisted Coaching Reduces Adverse Tracheal Intubation-Associated Events in the PICU*
Giuliano J, Krishna A, Napolitano N, Panisello J, Shenoi A, Sanders R, Rehder K, Al-Subu A, Brown C, Edwards L, Wright L, Pinto M, Harwayne-Gidansky I, Parsons S, Romer A, Laverriere E, Shults J, Yamada N, Walsh C, Nadkarni V, Nishisaki A, Network F. Implementation of Video Laryngoscope-Assisted Coaching Reduces Adverse Tracheal Intubation-Associated Events in the PICU*. Critical Care Medicine 2023, 51: 936-947. PMID: 37058348, DOI: 10.1097/ccm.0000000000005847.Peer-Reviewed Original ResearchCommunity-Onset Bacterial Coinfection in Children Critically Ill With Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
Moffitt KL, Nakamura MM, Young CC, Newhams MM, Halasa NB, Reed JN, Fitzgerald JC, Spinella PC, Soma VL, Walker TC, Loftis LL, Maddux AB, Kong M, Rowan CM, Hobbs CV, Schuster JE, Riggs BJ, McLaughlin GE, Michelson KN, Hall MW, Babbitt CJ, Cvijanovich NZ, Zinter MS, Maamari M, Schwarz AJ, Singh AR, Flori HR, Gertz SJ, Staat MA, Giuliano JS Jr, Hymes SR, Clouser KN, McGuire J, Carroll CL, Thomas NJ, Levy ER, Randolph AG. Community-Onset Bacterial Coinfection in Children Critically Ill With Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Open Forum Infect Dis 2023, 10: ofad122. PMID: 36968962, DOI: 10.1093/ofid/ofad122.Peer-Reviewed Original Research
2022
Investigating Health Disparities Associated With Multisystem Inflammatory Syndrome in Children After SARS-CoV-2 Infection
Zambrano LD, Ly KN, Link-Gelles R, Newhams MM, Akande M, Wu MJ, Feldstein LR, Tarquinio KM, Sahni LC, Riggs BJ, Singh AR, Fitzgerald JC, Schuster JE, Giuliano JS, Englund JA, Hume JR, Hall MW, Osborne CM, Doymaz S, Rowan CM, Babbitt CJ, Clouser KN, Horwitz SM, Chou J, Patel MM, Hobbs C, Randolph AG, Campbell AP, Investigators F. Investigating Health Disparities Associated With Multisystem Inflammatory Syndrome in Children After SARS-CoV-2 Infection. The Pediatric Infectious Disease Journal 2022, 41: 891-898. PMID: 36102740, PMCID: PMC9555608, DOI: 10.1097/inf.0000000000003689.Peer-Reviewed Original ResearchConceptsMIS-C casesNon-Hispanic black childrenInflammatory syndromeRisk factorsMedical conditionsMixed-effects multivariable logistic regressionSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2SARS-CoV-2 infectionRespiratory syndrome coronavirus 2MIS-C patientsMultisystem inflammatory syndromeUnderlying medical conditionsMultivariable logistic regressionSyndrome coronavirus 2Case-control studyNon-Hispanic blacksBlack childrenMultivariable analysisPediatric hospitalCoronavirus 2Insurance statusIndependent factorsSimilar sexSocial Vulnerability IndexLife-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children
Halasa NB, Spieker AJ, Young CC, Olson SM, Newhams MM, Amarin JZ, Moffitt KL, Nakamura MM, Levy ER, Soma VL, Talj R, Weiss SL, Fitzgerald JC, Mack EH, Maddux AB, Schuster JE, Coates BM, Hall MW, Schwartz SP, Schwarz AJ, Kong M, Spinella PC, Loftis LL, McLaughlin GE, Hobbs CV, Rowan CM, Bembea MM, Nofziger RA, Babbitt CJ, Bowens C, Flori HR, Gertz SJ, Zinter MS, Giuliano JS, Hume JR, Cvijanovich NZ, Singh AR, Crandall HA, Thomas NJ, Cullimore ML, Patel MM, Randolph AG, Kong M, Gaspers M, Typpo K, Sanders R, Katherine I, Peter M, Schwarz A, Babbitt C, Helen H, Cvijanovich N, Zinter M, Maddux A, Osborne C, Sara S, Mourani P, Emily P, Van K, Carroll C, Giuliano J, McLaughlin G, Tarquinio K, Michelson K, Coates B, Rowan C, Wellnitz K, Bhoojhawon, Sullivan J, Montgomery V, Havlin K, Bradford T, Riggs B, Bembea M, Randolph A, Newhams M, Chen S, Young C, Moffitt K, Nakamura M, Carroll R, Yager P, Fernandes N, Flori H, Heidemann S, Hume J, Levy E, Hobbs C, Martin L, Malloch L, Inagaki K, Dhanrajani A, Schuster J, Kietzman A, Hill S, Spinella P, Cullimore M, McCulloh R, Clouser K, Gertz S, Kleinman L, Li S, Horwitz S, Ratner A, Dapul H, Soma V, Keenaghan M, Singh A, Harwayne-Gidansky I, Hymes S, Doymaz S, Schwartz S, Walker T, Hall M, Shein S, Lansell A, Nofziger R, Staat M, Fitzgerald J, Weiss S, Thomas N, Fink E, Carcillo J, Mack E, Smallcomb L, Halasa N, Stewart L, Romero Y, Hayek H, Loftis L, Munoz A, Bowens C, Maamari M, Crandall H, Smith L, McGuire J. Life-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children. Clinical Infectious Diseases 2022, 76: ciac477. PMID: 35717646, PMCID: PMC9384330, DOI: 10.1093/cid/ciac477.Peer-Reviewed Original ResearchConceptsLife-threatening complicationsOdds of deathCoronavirus disease 2019Clinical characteristicsDisease 2019COVID-19US childrenLife supportHigher-acuity unitsInvasive mechanical ventilationShorter hospital stayNon-Hispanic blacksVasopressor supportHospital stayCritical illnessMembrane oxygenationPediatric patientsInfluenza infectionMechanical ventilationIntensive careClinical differencesUnderlying conditionDisease severityInfluenzaMixed-effects modelsFacilitators and Barriers to Implementing Two Quality Improvement Interventions Across 10 Pediatric Intensive Care Units: Video Laryngoscopy-Assisted Coaching and Apneic Oxygenation.
Davis KF, Rosenblatt S, Buffman H, Polikoff L, Napolitano N, Giuliano JS, Sanders RC, Edwards LR, Krishna AS, Parsons SJ, Al-Subu A, Krawiec C, Harwayne-Gidansky I, Vanderford P, Salfity N, Lane-Fall M, Nadkarni V, Nishisaki A. Facilitators and Barriers to Implementing Two Quality Improvement Interventions Across 10 Pediatric Intensive Care Units: Video Laryngoscopy-Assisted Coaching and Apneic Oxygenation. American Journal Of Medical Quality : The Official Journal Of The American College Of Medical Quality 2022, 37: 255-265. PMID: 34935683, DOI: 10.1097/JMQ.0000000000000032.Peer-Reviewed Original ResearchA Description of COVID-19-Directed Therapy in Children Admitted to US Intensive Care Units 2020
Schuster JE, Halasa NB, Nakamura M, Levy ER, Fitzgerald JC, Young CC, Newhams MM, Bourgeois F, Staat MA, Hobbs CV, Dapul H, Feldstein LR, Jackson AM, Mack EH, Walker TC, Maddux AB, Spinella PC, Loftis LL, Kong M, Rowan CM, Bembea MM, McLaughlin GE, Hall MW, Babbitt CJ, Maamari M, Zinter MS, Cvijanovich NZ, Michelson KN, Gertz SJ, Carroll CL, Thomas NJ, Giuliano JS, Singh AR, Hymes SR, Schwarz AJ, McGuire JK, Nofziger RA, Flori HR, Clouser KN, Wellnitz K, Cullimore ML, Hume JR, Patel M, Randolph AG, Investigators O. A Description of COVID-19-Directed Therapy in Children Admitted to US Intensive Care Units 2020. Journal Of The Pediatric Infectious Diseases Society 2022, 11: piab123-. PMID: 35022779, PMCID: PMC8807297, DOI: 10.1093/jpids/piab123.Peer-Reviewed Original ResearchConceptsCOVID-19-directed therapiesAcute coronavirus disease 2019Life-threatening COVID-19COVID-19Acute COVID-19Underlying medical conditionsIntensive care unitHigh-acuity careCoronavirus disease 2019Half of childrenYears of ageCharacteristics of childrenRemdesivir useSystemic steroidsRespiratory supportClinical courseCare unitPediatric hospitalSpecific therapyPediatric dataIll childrenLaboratory valuesDisease 2019Medical conditionsUS hospitalsIntubation practice and outcomes among pediatric emergency departments: A report from National Emergency Airway Registry for Children (NEAR4KIDS)
Capone CA, Emerson B, Sweberg T, Polikoff L, Turner DA, Adu‐Darko M, Li S, Glater‐Welt L, Howell J, Brown CA, Donoghue A, Krawiec C, Shults J, Breuer R, Swain K, Shenoi A, Krishna AS, Al‐Subu A, Harwayne‐Gidansky I, Biagas KV, Kelly SP, Nuthall G, Panisello J, Napolitano N, Giuliano JS, Emeriaud G, Toedt‐Pingel I, Lee A, Page‐Goertz C, Kimura D, Kasagi M, D'Mello J, Parsons SJ, Mallory P, Gima M, Bysani GK, Motomura M, Tarquinio KM, Nett S, Ikeyama T, Shetty R, Sanders RC, Lee JH, Pinto M, Orioles A, Jung P, Shlomovich M, Nadkarni V, Nishisaki A, for the National Emergency Airway Registry for Children Investigators P. Intubation practice and outcomes among pediatric emergency departments: A report from National Emergency Airway Registry for Children (NEAR4KIDS). Academic Emergency Medicine 2022, 29: 406-414. PMID: 34923705, DOI: 10.1111/acem.14431.Peer-Reviewed Original ResearchConceptsPediatric emergency departmentNational Emergency Airway RegistryLimited mouth openingEmergency departmentAirway RegistryOxygen desaturationIntubation practicesMouth openingLimited neck mobilityMedian patient ageTracheal intubation practiceQuality improvement targetsRespiratory decompensationCardiac ICUNeurologic deteriorationPatient ageProcedural successNeck mobilityMultivariable modelICUOutcomesRegistryDesaturationChildren databaseDepartmentPediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary.
Bembea MM, Agus M, Akcan-Arikan A, Alexander P, Basu R, Bennett TD, Bohn D, Brandão LR, Brown AM, Carcillo JA, Checchia P, Cholette J, Cheifetz IM, Cornell T, Doctor A, Eckerle M, Erickson S, Farris RWD, Faustino EVS, Fitzgerald JC, Fuhrman DY, Giuliano JS, Guilliams K, Gaies M, Gorga SM, Hall M, Hanson SJ, Hartman M, Hassinger AB, Irving SY, Jeffries H, Jouvet P, Kannan S, Karam O, Khemani RG, Kissoon N, Lacroix J, Laussen P, Leclerc F, Lee JH, Leteurtre S, Lobner K, McKiernan PJ, Menon K, Monagle P, Muszynski JA, Odetola F, Parker R, Pathan N, Pierce RW, Pineda J, Prince JM, Robinson KA, Rowan CM, Ryerson LM, Sanchez-Pinto LN, Schlapbach LJ, Selewski DT, Shekerdemian LS, Simon D, Smith LS, Squires JE, Squires RH, Sutherland SM, Ouellette Y, Spaeder MC, Srinivasan V, Steiner ME, Tasker RC, Thiagarajan R, Thomas N, Tissieres P, Traube C, Tucci M, Typpo KV, Wainwright MS, Ward SL, Watson RS, Weiss S, Whitney J, Willson D, Wynn JL, Yehya N, Zimmerman JJ. Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary. Pediatrics 2022, 149: s1-s12. PMID: 34970673, PMCID: PMC9599725, DOI: 10.1542/peds.2021-052888b.Peer-Reviewed Original ResearchConceptsMultiple organ dysfunctionOrgan dysfunctionIll childrenElectronic data extraction formSingle organ dysfunctionPrognosis Studies toolRisk of biasImmune system dysfunctionMedical Subject Headings termsEvidence-based criteriaData extraction formSubject Headings termsAcute liverSystem dysfunctionClinical assessmentElectronic searchDysfunctionExtraction formSystematic reviewAvailable evidenceExpert panelMeaningful outcomesStudy identificationChildrenStudy toolEndothelial Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.
Pierce RW, Giuliano JS, Whitney JE, Ouellette Y. Endothelial Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics 2022, 149: s97-s102. PMID: 34970676, PMCID: PMC9754809, DOI: 10.1542/peds.2021-052888o.Peer-Reviewed Original ResearchConceptsMultiple organ dysfunction syndromeOrgan dysfunction syndromeEndothelial dysfunctionIll childrenDysfunction syndromeEndothelial functionPediatric multiple organ dysfunction syndromeVascular segmentsOrgan systemsStandard data extraction formOrgan-specific outcomesPediatric critical illnessPODIUM Consensus ConferencePatient-centered outcomesNon-English language studiesCombination of biomarkersData extraction formStudies of adultsCritical illnessCase seriesPremature infantsFunctional statusEligible studiesBias assessmentLeukocyte recruitment
2021
Data-driven clustering identifies features distinguishing multisystem inflammatory syndrome from acute COVID-19 in children and adolescents
Geva A, Patel MM, Newhams MM, Young CC, Son MBF, Kong M, Maddux AB, Hall MW, Riggs BJ, Singh AR, Giuliano JS, Hobbs CV, Loftis LL, McLaughlin GE, Schwartz SP, Schuster JE, Babbitt CJ, Halasa NB, Gertz SJ, Doymaz S, Hume JR, Bradford TT, Irby K, Carroll CL, McGuire JK, Tarquinio KM, Rowan CM, Mack EH, Cvijanovich NZ, Fitzgerald JC, Spinella PC, Staat MA, Clouser KN, Soma VL, Dapul H, Maamari M, Bowens C, Havlin KM, Mourani PM, Heidemann SM, Horwitz SM, Feldstein LR, Tenforde MW, Newburger JW, Mandl KD, Randolph AG, Investigators O. Data-driven clustering identifies features distinguishing multisystem inflammatory syndrome from acute COVID-19 in children and adolescents. EClinicalMedicine 2021, 40: 101112. PMID: 34485878, PMCID: PMC8405351, DOI: 10.1016/j.eclinm.2021.101112.Peer-Reviewed Original ResearchSARS-CoV-2 PCRCluster 1 patientsInflammatory syndromeClinical featuresPositive SARS-CoV-2 PCRAcute COVID-19 pneumoniaCOVID-19 pulmonary diseaseCOVID-19-related illnessChest radiograph infiltratesHigher inflammatory biomarkersPositive PCR testingAcute COVID-19Multisystem inflammatory syndromeCOVID-19 pneumoniaDiagnosis of MISCluster 3 patientsCluster 2 patientsClusters of patientsPre-existing conditionsPulmonary infiltratesInflammatory biomarkersMucocutaneous involvementPulmonary diseaseRadiographic findingsMean ageMultisystem Inflammatory Syndrome in Children — Initial Therapy and Outcomes
Son MBF, Murray N, Friedman K, Young CC, Newhams MM, Feldstein LR, Loftis LL, Tarquinio KM, Singh AR, Heidemann SM, Soma VL, Riggs BJ, Fitzgerald JC, Kong M, Doymaz S, Giuliano JS, Keenaghan MA, Hume JR, Hobbs CV, Schuster JE, Clouser KN, Hall MW, Smith LS, Horwitz SM, Schwartz SP, Irby K, Bradford TT, Maddux AB, Babbitt CJ, Rowan CM, McLaughlin GE, Yager PH, Maamari M, Mack EH, Carroll CL, Montgomery VL, Halasa NB, Cvijanovich NZ, Coates BM, Rose CE, Newburger JW, Patel MM, Randolph AG. Multisystem Inflammatory Syndrome in Children — Initial Therapy and Outcomes. New England Journal Of Medicine 2021, 385: 23-34. PMID: 34133855, PMCID: PMC8220972, DOI: 10.1056/nejmoa2102605.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild, PreschoolCohort StudiesCombined Modality TherapyCOVID-19COVID-19 Drug TreatmentDrug Therapy, CombinationFemaleGlucocorticoidsHospitalizationHumansImmunoglobulins, IntravenousImmunomodulationInfantLogistic ModelsMalePropensity ScorePublic Health SurveillanceShockSystemic Inflammatory Response SyndromeTreatment OutcomeVentricular Dysfunction, LeftYoung AdultConceptsIntravenous immune globulinMultisystem inflammatory syndromeCardiovascular dysfunctionDay 2Immunomodulatory therapyInflammatory syndromePrimary outcomeInitial treatmentLower riskRisk of feverReal-world effectivenessYears of agePropensity-score matchingImmunomodulatory medicationsVasopressor useVentricular dysfunctionAdjunctive therapyComposite outcomeImmune globulinSecondary outcomesAdjunctive treatmentRecurrent feverInverse probability weightingDay 1GlucocorticoidsIncidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2
Payne AB, Gilani Z, Godfred-Cato S, Belay ED, Feldstein LR, Patel MM, Randolph AG, Newhams M, Thomas D, Magleby R, Hsu K, Burns M, Dufort E, Maxted A, Pietrowski M, Longenberger A, Bidol S, Henderson J, Sosa L, Edmundson A, Tobin-D’Angelo M, Edison L, Heidemann S, Singh AR, Giuliano JS, Kleinman LC, Tarquinio KM, Walsh RF, Fitzgerald JC, Clouser KN, Gertz SJ, Carroll RW, Carroll CL, Hoots BE, Reed C, Dahlgren FS, Oster ME, Pierce TJ, Curns AT, Langley GE, Campbell AP, Balachandran N, Murray T, Burkholder C, Brancard T, Lifshitz J, Leach D, Charpie I, Tice C, Coffin S, Perella D, Jones K, Marohn K, Yager P, Fernandes N, Flori H, Koncicki M, Walker K, Di Pentima M, Li S, Horwitz S, Gaur S, Coffey D, Harwayne-Gidansky I, Hymes S, Thomas N, Ackerman K, Cholette J. Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2. JAMA Network Open 2021, 4: e2116420. PMID: 34110391, PMCID: PMC8193431, DOI: 10.1001/jamanetworkopen.2021.16420.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionMultisystem inflammatory syndromeRace/ethnicityInflammatory syndromeCohort studyPacific Islander personsAge groupsCurrent SARS-CoV-2 infectionIncidence of MISPopulation-based incidenceWhite personsPopulation-based estimatesEnhanced surveillance dataSARS-CoV-2Rare complicationCOVID-19 casesLatino personsNational surveillanceMAIN OUTCOMEInfectionDisease controlIncidenceSurveillance dataCOVID-19Further studiesNeurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome
LaRovere KL, Riggs BJ, Poussaint TY, Young CC, Newhams MM, Maamari M, Walker TC, Singh AR, Dapul H, Hobbs CV, McLaughlin GE, Son MBF, Maddux AB, Clouser KN, Rowan CM, McGuire JK, Fitzgerald JC, Gertz SJ, Shein SL, Munoz AC, Thomas NJ, Irby K, Levy ER, Staat MA, Tenforde MW, Feldstein LR, Halasa NB, Giuliano JS, Hall MW, Kong M, Carroll CL, Schuster JE, Doymaz S, Loftis LL, Tarquinio KM, Babbitt CJ, Nofziger RA, Kleinman LC, Keenaghan MA, Cvijanovich NZ, Spinella PC, Hume JR, Wellnitz K, Mack EH, Michelson KN, Flori HR, Patel MM, Randolph AG, Last Name* F, Gaspers M, Typpo K, Sanders R, Schwarz A, Harvey H, Zinter M, Mourani P, Coates B, Bhoojhawon G, Havlin K, Montgomery V, Sullivan J, Bradford T, Bembea M, Lipton S, Graciano A, Chen S, Kucukak S, Newburger J, Carroll R, Fernandes N, Yager P, Marohn K, Heidemann S, Cullimore M, McCulloh R, Horwitz S, Li S, Walsh R, Ratner A, Soma V, Gillen J, Zackai S, Ackerman K, Cholette J, Harwayne-Gidansky I, Hymes S, Overby P, Schwartz S, Lansell A, Koncicki M, Carcillo J, Fink E, Kimura D, Bowens C, Crandall H, Smith L, Cengiz P. Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome. JAMA Neurology 2021, 78: 536-547. PMID: 33666649, PMCID: PMC7936352, DOI: 10.1001/jamaneurol.2021.0504.Peer-Reviewed Original ResearchConceptsMultisystem inflammatory syndromeNeurologic involvementInflammatory syndromeLife-threatening conditionHospital dischargeTransient symptomsNeurologic conditionsPositive severe acute respiratory syndrome coronavirus 2 test resultCOVID-19Severe acute respiratory syndrome coronavirus 2Life-threatening neurologic conditionAcute respiratory syndrome coronavirus 2Long-term neurodevelopmental outcomesRespiratory syndrome coronavirus 2Fatal neurologic conditionFulminant cerebral edemaLife-threatening involvementNew neurologic deficitsAcute neurologic signsSyndrome coronavirus 2Coronavirus disease 2019Public health registriesFibrinogen equivalent unitsAdult patientsCerebral edemaUnintentional Window Falls in Children and Adolescents.
Flaherty MR, Raybould T, Savarino J, Yager P, Mooney DP, Farr BJ, Giuliano JS, Neeman E, Campbell BT, Thaker S, McKiernan C, Lewis D, Epp TK, Baertschiger RM, Jackson CA, Rideout L, Shah A, Falank C, Ontengco J, Cairo S, McLoughlin RJ, Aidlen JT, Watson-Smith D, Wills H, Masiakos PT. Unintentional Window Falls in Children and Adolescents. Academic Pediatrics 2021, 21: 497-503. PMID: 32653687, DOI: 10.1016/j.acap.2020.07.008.Peer-Reviewed Original ResearchCharacteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19
Feldstein LR, Tenforde MW, Friedman KG, Newhams M, Rose EB, Dapul H, Soma VL, Maddux AB, Mourani PM, Bowens C, Maamari M, Hall MW, Riggs BJ, Giuliano JS, Singh AR, Li S, Kong M, Schuster JE, McLaughlin GE, Schwartz SP, Walker TC, Loftis LL, Hobbs CV, Halasa NB, Doymaz S, Babbitt CJ, Hume JR, Gertz SJ, Irby K, Clouser KN, Cvijanovich NZ, Bradford TT, Smith LS, Heidemann SM, Zackai SP, Wellnitz K, Nofziger RA, Horwitz SM, Carroll RW, Rowan CM, Tarquinio KM, Mack EH, Fitzgerald JC, Coates BM, Jackson AM, Young CC, Son MBF, Patel MM, Newburger JW, Randolph AG. Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19. JAMA 2021, 325: 1074-1087. PMID: 33625505, PMCID: PMC7905703, DOI: 10.1001/jama.2021.2091.Peer-Reviewed Original ResearchConceptsMultisystem inflammatory syndromeOrgan system involvementInflammatory syndromeCase seriesSystem involvementCardiorespiratory involvementCOVID-19Positive severe acute respiratory syndrome coronavirus 2Higher C-reactive protein levelsPositive RT-PCR test resultsSevere acute respiratory syndrome coronavirus 2Severe acute COVID-19Acute respiratory syndrome coronavirus 2C-reactive protein levelsSevere coronavirus disease 2019Left ventricular systolic functionRT-PCR test resultsRespiratory syndrome coronavirus 2Organ system complicationsAcute COVID-19Coronary artery aneurysmsVentricular systolic functionLow platelet countAntibody test resultsIntensive care unit