Featured Publications
Regular cannabis use is associated with history of childhood and lifetime trauma in a non-clinical community sample
Bassir Nia A, Weleff J, Fogelman N, Nourbakhsh S, Sinha R. Regular cannabis use is associated with history of childhood and lifetime trauma in a non-clinical community sample. Journal Of Psychiatric Research 2023, 159: 159-164. PMID: 36736285, PMCID: PMC10024801, DOI: 10.1016/j.jpsychires.2023.01.036.Peer-Reviewed Original ResearchConceptsMajor life eventsChildhood traumaLife eventsChildhood Trauma QuestionnaireLifetime traumaCannabis useNon-clinical community sampleChronic stressNeurobiology of stressRegular cannabis useGender differencesRegular useSelf-report questionnairesRecent life eventsPotential gender differencesCross-sectional studyUrine drug testingLife traumaLogistic regression analysisAdversity indexCommunity sampleCannabis usersTrauma QuestionnaireHigh rateSubstance useKey Updates to Understanding Roles of Childhood Trauma in Overall Health.
Weleff J, Potter D. Key Updates to Understanding Roles of Childhood Trauma in Overall Health. The AMA Journal Of Ethic 2023, 25: e116-122. PMID: 36754073, DOI: 10.1001/amajethics.2023.116.Peer-Reviewed Original ResearchThe Zero Suicide Model in Addiction Treatment Settings: Recognizing the Need for Feasibility and Implementation Data
Arakelian M, Barnett B, Weleff J. The Zero Suicide Model in Addiction Treatment Settings: Recognizing the Need for Feasibility and Implementation Data. Psychiatric Services 2023, 75: 378-380. PMID: 37933133, DOI: 10.1176/appi.ps.20230175.Peer-Reviewed Original ResearchConceptsAddiction treatment settingsTreatment settingsZero SuicideSubstance use disordersZero Suicide modelAddiction outcomesUse disorderSuicide modelsAddiction treatmentHealth care settingsAddictionHealth care systemSuicide preventionSuicideImplement best practicesCare settingsCare systemOpen ForumIncreased riskBest practicesHealthDisordersSetsResearchCliniciansDysregulation of the endogenous cannabinoid system following opioid exposure
Mohammad Aghaei A, Saali A, Canas M, Weleff J, D'Souza D, Angarita G, Bassir Nia A. Dysregulation of the endogenous cannabinoid system following opioid exposure. Psychiatry Research 2023, 330: 115586. PMID: 37931479, PMCID: PMC10842415, DOI: 10.1016/j.psychres.2023.115586.Peer-Reviewed Original ResearchConceptsEndocannabinoid systemECS componentsBrain regionsNovel neurobiological targetsTreatment of OUDEndogenous opioid systemOpioid-related deathsEndogenous cannabinoid systemSpecific brain regionsECS dysregulationOpioid exposureOUD treatmentOpioid systemCannabinoid systemNeurobiological targetsNew medicationsPreclinical literatureCannabinoid receptorsEndogenous ligandTherapeutic potentialStudy typePresent potential targetsExposure protocolOpioidsPreclinical researchRace, economic status, and disparities in the receipt of benzodiazepine prescriptions in a large primary care sample
Dore S, Weleff J, Anand A, Thompson N, Barnett B. Race, economic status, and disparities in the receipt of benzodiazepine prescriptions in a large primary care sample. General Hospital Psychiatry 2023, 85: 28-34. PMID: 37729721, DOI: 10.1016/j.genhosppsych.2023.09.002.Peer-Reviewed Original ResearchConceptsAmerican patientsAsian American patientsPatient characteristicsBenzodiazepine prescriptionsWhite patientsCohort of patientsEconomic statusMultivariate logistic regressionAfrican American patientsPrescription of benzodiazepinesLow-income zip codesPatient's economic statusPrimary care contextPrimary care samplePrimary care visitsPrimary care clinicsLower-income patientsRetrospective studyPrescribed benzodiazepinesPatientsBenzodiazepinesCare sampleBenzodiazepine prescribingCare clinicsCare visitsClinical Presentations and Treatment of Phenibut Toxicity and Withdrawal: A Systematic Literature Review
Weleff J, Kovacevich A, Burson J, Nero N, Anand A. Clinical Presentations and Treatment of Phenibut Toxicity and Withdrawal: A Systematic Literature Review. Journal Of Addiction Medicine 2023, 17: 407-417. PMID: 37579098, DOI: 10.1097/adm.0000000000001141.Peer-Reviewed Original ResearchConceptsWithdrawal casesClinical presentationConcomitant substance useLength of hospital stayAverage length of hospital staySystematic treatment protocolCochrane Library databasesAtypical antipsychoticsComprehensive literature searchSubstance useAddictive agentHospital stayPublished casesBenzodiazepinesPhenibutLibrary databasesToxicity casesAntipsychoticsTreatment protocolsPsychosisWithdrawalMultiple medicationsAverage ageMental statusMovement disordersAn Analysis of Benzodiazepine Prescribing to Primary Care Patients in a Large Healthcare System from 2019-2020
Weleff J, Anand A, Squeri M, Sieke R, Thompson N, Barnett B. An Analysis of Benzodiazepine Prescribing to Primary Care Patients in a Large Healthcare System from 2019-2020. Journal Of Psychoactive Drugs 2023, 56: 245-256. PMID: 36940298, DOI: 10.1080/02791072.2023.2191610.Peer-Reviewed Original ResearchConceptsBenzodiazepine prescribingBenzodiazepine prescriptionsPrimary care visitsPrimary care patientsPrimary care providersEffect sizePrimary care settingPost-lockdownBenzodiazepine prescribing ratesMultivariate logistic regressionCare visitsCare providersCare settingsPrescription receiptRetrospective cohort studyCare patientsRacial disparitiesPrescribing ratesNational ratesHealthcare systemAdult patientsDiagnosis codesCocaine use disorderCohort studyPrescribingWhy Harm Reduction and Equity Are Ethical Imperatives in Opioid Use Disorder Care.
Weleff J. Why Harm Reduction and Equity Are Ethical Imperatives in Opioid Use Disorder Care. The AMA Journal Of Ethic 2024, 26: e509-511. PMID: 38958418, DOI: 10.1001/amajethics.2024.509.Peer-Reviewed Original Research
2024
Diagnosis and treatment of Wernicke's encephalopathy: A systematic literature review
Cantu-Weinstein A, Branning R, Alamir M, Weleff J, Do M, Nero N, Anand A. Diagnosis and treatment of Wernicke's encephalopathy: A systematic literature review. General Hospital Psychiatry 2024, 87: 48-59. PMID: 38306946, DOI: 10.1016/j.genhosppsych.2024.01.005.Peer-Reviewed Original ResearchConceptsWernicke's encephalopathyCase reportIV thiamineRandomized controlled trialsComplete resolution of symptomsTreatment of Wernicke's encephalopathyControlled trialsAverage ageResolution of symptomsDiagnosing WEWE patientsCross-sectional studyComplete resolutionRetrospective studyClinical findingsProspective studyNeurological symptomsTreatment guidelinesDiagnostic standardHuman studiesThiamine treatmentInclusion criteriaClinical guidelinesCognitive dysfunctionSystematic review
2023
All a-BORG! The Dangerous Drinking Trend Steamrolling Across Social Media and College Campuses
Pratt N, Madhavan R, Weigle P, Weleff J. All a-BORG! The Dangerous Drinking Trend Steamrolling Across Social Media and College Campuses. Journal Of Addiction Medicine 2023, 18: 4-5. PMID: 37910186, DOI: 10.1097/adm.0000000000001240.Peer-Reviewed Original ResearchPrescribing of Z-Drugs With and Without Opioid Coprescribing to Primary Care Patients in a Large Health Care System From 2019-2020.
Anand A, Weleff J, Thompson N, Barnett B. Prescribing of Z-Drugs With and Without Opioid Coprescribing to Primary Care Patients in a Large Health Care System From 2019-2020. The Journal Of Clinical Psychiatry 2023, 84 PMID: 37707315, DOI: 10.4088/jcp.22m14753.Peer-Reviewed Original ResearchConceptsZ-drug prescribingDiagnosis of opioid use disorderZ-drug prescriptionsOpioid use disorderZ-drugsHealth care systemPrimary care clinicsWhite raceUse disorderCare systemAssociated with increasing ageCare clinicsOlder ageStudy periodDiagnosis of bipolar disorderCross-sectional studyPrimary care patientsLarger health care systemAdult patientsPatient populationOpioidGeneralized anxiety disorderPatientsBipolar disorderPost-lockdownThree Cases of Reported Improvement in Microsmia and Anosmia Following Naturalistic Use of Psilocybin and LSD
Kovacevich A, Weleff J, Claytor B, Barnett B. Three Cases of Reported Improvement in Microsmia and Anosmia Following Naturalistic Use of Psilocybin and LSD. Journal Of Psychoactive Drugs 2023, 55: 672-679. PMID: 37650700, DOI: 10.1080/02791072.2023.2253538.Peer-Reviewed Original ResearchConceptsLysergic acid diethylamidePsychedelic useOlfactory impairmentOlfactory improvementClassic psychedelic useCOVID-19-related anosmiaSerotonergic effectsIncreased neuroplasticityAnti-inflammatory effectsNaturalistic useAcid diethylamideOlfactory dysfunctionMicrosmiaPsilocybinRespiratory infectionsPsilocybin mushroomsTherapeutic benefitAnosmiaNovel treatmentReport improvementImpairmentPotential mechanismsBiological plausibilityGrowing bodyWomenPhencyclidine Positivity on Urine Drug Screening in Patients Treated for Alcohol Withdrawal on a Dual-diagnosis Medically Assisted Withdrawal Unit
Wang P, Dore S, Weleff J, Butler R, Barnett B. Phencyclidine Positivity on Urine Drug Screening in Patients Treated for Alcohol Withdrawal on a Dual-diagnosis Medically Assisted Withdrawal Unit. Journal Of Addiction Medicine 2023, 17: 695-701. PMID: 37934534, DOI: 10.1097/adm.0000000000001217.Peer-Reviewed Original ResearchConceptsAlcohol withdrawalLength of stayPCP-positiveDual diagnosisMultivariate logistic regressionAlcohol use disorderRisk of readmissionToxicological screeningLogistic regressionRetrospective study of patientsSurvival analysisUrine drug screensUrine toxicology screenWithdrawing unitUse disorderAdmission toxicology screeningStudy of patientsCocaine positivityStatistically significant associationPhencyclidineMultivariate linear regression modelPCPRetrospective studyUnivariate testsCocaineMethamphetamine-associated catatonia: Case series and systematic review of the literature from 1943-2020.
Slavnic B, Barnett B, McIntire S, Becker R, Saba S, Vellanki K, Honaker L, Weleff J, Carroll B. Methamphetamine-associated catatonia: Case series and systematic review of the literature from 1943-2020. Annals Of Clinical Psychiatry 2023, 35: 167-177. PMID: 37459499, DOI: 10.12788/acp.0116.Peer-Reviewed Original ResearchConceptsAssociated with catatoniaCatatonia Rating ScaleMethamphetamine useGeneral medical conditionsCase seriesBush-Francis Catatonia Rating ScaleSystematic reviewUrine drug screensMedical conditionsRating ScaleCases of catatoniaDSM-5 criteriaShorter hospitalDopamine functionCatatonic patientsCatatoniaDSM-5MethamphetaminePatientsNeural mechanismsSubstance intoxicationDrug screeningHospitalReviewLorazepamAntemortem Health System Utilization in People Experiencing Homelessness Who Died in the Emergency Department.
Seballos S, Kanyo E, Weleff J, Pan E, Butler R, Lopez R, Phelan M. Antemortem Health System Utilization in People Experiencing Homelessness Who Died in the Emergency Department. Journal Of Health Care For The Poor And Underserved 2023, 34: 640-651. PMID: 37464523, DOI: 10.1353/hpu.2023.0055.Peer-Reviewed Original ResearchConceptsHealth system utilizationEmergency departmentArrival of emergency medical servicesHealth care utilization patternsCardiopulmonary resuscitationEmergency department characteristicsUnderutilize health servicesHealth system contactEmergency department utilizationCare utilization patternsHealth care utilizationEmergency medical servicesProportion of decedentsBystander cardiopulmonary resuscitationEmergency department encountersCardiac arrestSubstance use-relatedCare utilizationHealth servicesPre-hospitalMedical servicesDescriptive statisticsDepartment characteristicsMortality riskIn-hospital characteristicsDisparities in Prostate Cancer Diagnoses Among Persons Experiencing Homelessness
Mayo Z, Parker S, Kilic S, Weleff J, Phelan M, Mian O, Stephans K, Suh J, Tendulkar R. Disparities in Prostate Cancer Diagnoses Among Persons Experiencing Homelessness. European Urology 2023, 84: 144-145. PMID: 37031006, DOI: 10.1016/j.eururo.2023.03.024.Peer-Reviewed Original ResearchImproving Treatment Interventions and Cancer Outcomes in Persons Experiencing Homelessness: A Population Underrepresented in Equity Initiatives
Mayo Z, Campbell S, Shah C, Weleff J, Kilic S. Improving Treatment Interventions and Cancer Outcomes in Persons Experiencing Homelessness: A Population Underrepresented in Equity Initiatives. International Journal Of Radiation Oncology • Biology • Physics 2023, 115: 302-304. PMID: 36621233, DOI: 10.1016/j.ijrobp.2022.09.059.Peer-Reviewed Original ResearchCancer Diagnoses and Use of Radiation Therapy Among Persons Experiencing Homelessness
Kilic S, Mayo Z, Weleff J, Parker S, Strzalka C, Phelan M, Suh J, Campbell S, Shah C. Cancer Diagnoses and Use of Radiation Therapy Among Persons Experiencing Homelessness. International Journal Of Radiation Oncology • Biology • Physics 2023, 116: 79-86. PMID: 36731679, DOI: 10.1016/j.ijrobp.2023.01.034.Peer-Reviewed Original ResearchConceptsRadiation therapyUse of radiation therapyCancer diagnosisNo treatmentExternal beam RTInstitutional cancer databaseSingle-modality treatmentDisease-free statusTreatment completion ratesBeam RTChart searchHypofractionated regimensMetastatic diseaseHormone therapyMultimodal therapyMedian ageRates of cancer screeningCancer DatabaseMultifraction treatmentTreated patientsCompletion ratesCancer screeningAdvanced stageMetropolitan hospital systemCancer prevalence
2022
Catatonia and Neuroleptic Malignant Syndrome in Patients With Cerebral Palsy: Two Case Reports and a Systematic Review of the Literature
Barnett B, Balaji D, Weleff J, Carroll B. Catatonia and Neuroleptic Malignant Syndrome in Patients With Cerebral Palsy: Two Case Reports and a Systematic Review of the Literature. Journal Of The Academy Of Consultation-Liaison Psychiatry 2022, 64: 277-293. PMID: 36586471, DOI: 10.1016/j.jaclp.2022.12.008.Peer-Reviewed Original ResearchConceptsCerebral palsyBaclofen withdrawalIntrathecal baclofen withdrawalAllied Health LiteraturePrevalence of catatoniaSpasticity managementIntrathecal baclofenCumulative IndexHealth literatureReports of catatoniaRecurrent self-limiting feverGroup of movement disordersService databasePalsyLifetime prevalenceOvid MEDLINESystematic reviewNeuroleptic malignant syndromePatient populationCase reportMovement disordersPsychotic disordersRoutine treatmentInduced neuroleptic malignant syndromeMalignant syndromeProstate Cancer Screening Disparities in Persons Experiencing Homelessness
Mayo Z, Kilic S, Weleff J, Parker S, Strzalka C, Phelan M, Mian O, Stephans K, Suh J, Tendulkar R. Prostate Cancer Screening Disparities in Persons Experiencing Homelessness. JCO Oncology Practice 2022, 18: e1866-e1873. PMID: 36206501, DOI: 10.1200/op.22.00412.Peer-Reviewed Original ResearchConceptsNon-PEHProstate-specific antigenPSA testingLikelihood of PSA testingRates of prostate cancer screeningProstate-specific antigen testing ratesProstate-specific antigen screeningProstate-specific antigen testingPSA screening ratesFactors associated with screeningTransitional housingPrivate insuranceMetropolitan hospital systemProstate cancer screeningUnivariate chi-square analysisPCP accessMultivariate logistic regressionTesting ratesHomeless sheltersHomelessnessCohort of personsInsuranceUnivariate analysisInstitutional registryMultivariate analysis