2020
Exenatide extended release in patients with type 1 diabetes with and without residual insulin production
Herold KC, Reynolds J, Dziura J, Baidal D, Gaglia J, Gitelman SE, Gottlieb PA, Marks J, Philipson LH, Pop‐Busui R, Weinstock RS. Exenatide extended release in patients with type 1 diabetes with and without residual insulin production. Diabetes Obesity And Metabolism 2020, 22: 2045-2054. PMID: 32573927, PMCID: PMC8009602, DOI: 10.1111/dom.14121.Peer-Reviewed Original ResearchMeSH KeywordsDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2ExenatideGlycated HemoglobinHumansHypoglycemic AgentsInsulinVenomsConceptsExenatide extended releaseResidual insulin productionBeta-cell functionType 1 diabetesC-peptidePlacebo groupPrimary outcomeWeek 12ER groupInsulin productionDetectable C-peptide levelsResidual beta-cell functionGLP-1 receptor agonistsRandomized placebo-controlled trialExtended releaseTotal insulin doseMean HbA1c levelPlacebo-controlled trialC-peptide levelsDetectable levelsCell functionShort-term improvementHbA1c levelsStudy drugAdverse events
2016
Effective Translation of an Intensive Lifestyle Intervention for Hispanic Women With Prediabetes in a Community Health Center Setting
Van Name MA, Camp AW, Magenheimer EA, Li F, Dziura JD, Montosa A, Patel A, Tamborlane WV. Effective Translation of an Intensive Lifestyle Intervention for Hispanic Women With Prediabetes in a Community Health Center Setting. Diabetes Care 2016, 39: 525-531. PMID: 26908915, PMCID: PMC4806769, DOI: 10.2337/dc15-1899.Peer-Reviewed Original ResearchMeSH KeywordsAdiposityAdolescentAdultAgedBody Mass IndexChoice BehaviorCommunity Health CentersDiabetes Mellitus, Type 2ExerciseFeasibility StudiesFemaleFood PreferencesHispanic or LatinoHumansInsulinLife StyleMiddle AgedPilot ProjectsPrediabetic StateRisk FactorsSocioeconomic FactorsWaist CircumferenceWeight LossYoung AdultConceptsIntensive lifestyle interventionDiabetes Prevention ProgramCommunity health center settingUsual care groupType 2 diabetesHealth center settingHispanic womenILI groupLifestyle interventionCare groupOral glucose tolerance testCenter settingLow-income Hispanic womenWeight lossSimilar baseline weightGlucose tolerance testPercent body fatType of interventionCHC settingsDPP interventionsUsual careBaseline weightWaist circumferenceGlucose excursionsTolerance test
2014
Reversal of Early Abnormalities in Glucose Metabolism in Obese Youth: Results of an Intensive Lifestyle Randomized Controlled Trial
Savoye M, Caprio S, Dziura J, Camp A, Germain G, Summers C, Li F, Shaw M, Nowicka P, Kursawe R, DePourcq F, Kim G, Tamborlane WV. Reversal of Early Abnormalities in Glucose Metabolism in Obese Youth: Results of an Intensive Lifestyle Randomized Controlled Trial. Diabetes Care 2014, 37: 317-324. PMID: 24062325, PMCID: PMC3898759, DOI: 10.2337/dc13-1571.Peer-Reviewed Original ResearchConceptsStandard of careClinical careBlood glucoseObese adolescentsObese youthOral glucose tolerance test glucoseIntensive lifestyle modificationDiabetes Prevention ProgramStandard clinical careInsulin sensitivity indexHealthy lifestyle programType 2 diabetesRisk of T2DChildhood obesity epidemicΒ-cell dysfunctionLifestyle modificationControlled TrialsOGTT glucosePrimary outcomeGlucose toleranceInsulin resistanceLifestyle programAnthropometric assessmentEarly abnormalitiesGlucose levels
2012
Effects on post-prandial glucose and AGE precursors from two initial insulin strategies in patients with Type 2 diabetes uncontrolled by oral agents
Sakharova OV, Lleva RR, Dziura JD, Spollett GR, Howell SK, Beisswenger PJ, Inzucchi SE. Effects on post-prandial glucose and AGE precursors from two initial insulin strategies in patients with Type 2 diabetes uncontrolled by oral agents. Journal Of Diabetes And Its Complications 2012, 26: 333-338. PMID: 22541894, DOI: 10.1016/j.jdiacomp.2012.03.027.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAgedBlood GlucoseBody WeightCross-Over StudiesDiabetes Mellitus, Type 2FastingFemaleGlycated HemoglobinGlycation End Products, AdvancedHumansHypoglycemic AgentsInsulin GlargineInsulin LisproInsulin, Long-ActingMaleMiddle AgedPostprandial PeriodTreatment FailureTreatment OutcomeConceptsOral anti-hyperglycemic drugsPost-prandial glucoseInsulin strategiesFree fatty acidsType 2Post-prandial glucose metabolismProgressive β-cell dysfunctionType 2 diabetes patientsPost-prandial glucose levelsDaily insulin glargineInitial insulin regimenPrecursor of AGEsSingle-center studyClinical Research CenterLong-term diabetic complicationsAnti-hyperglycemic drugsType 2 diabetesΒ-cell dysfunctionCross-over designInitial insulinInsulin regimenOral agentsInsulin regimensInsulin therapyOAD therapy
2010
Managing the Space between Visits: A Randomized Trial of Disease Management for Diabetes in a Community Health Center
Anderson DR, Christison-Lagay J, Villagra V, Liu H, Dziura J. Managing the Space between Visits: A Randomized Trial of Disease Management for Diabetes in a Community Health Center. Journal Of General Internal Medicine 2010, 25: 1116-1122. PMID: 20556536, PMCID: PMC2955486, DOI: 10.1007/s11606-010-1419-5.Peer-Reviewed Original ResearchMeSH KeywordsCommunity Health CentersDiabetes Mellitus, Type 2Disease ManagementFemaleHumansMaleOffice VisitsSocioeconomic FactorsTelemedicineTreatment OutcomeConceptsCommunity health centersUsual careBlood pressureUnderserved patientsHealth centersPhysical activityControl groupDisease management supportTelephonic Disease ManagementDiastolic blood pressureIntake of fruitsBody mass indexType 2 diabetesDisease managementSignificant differencesLow socioeconomic statusDisease management programsSelf-management servicesBehavioral outcome measuresParticipantsAll patientsGlycemic controlPrimary outcomeSuch patientsLDL cholesterolMass index
2009
A multifaceted school-based intervention to reduce risk for type 2 diabetes in at-risk youth
Grey M, Jaser SS, Holl MG, Jefferson V, Dziura J, Northrup V. A multifaceted school-based intervention to reduce risk for type 2 diabetes in at-risk youth. Preventive Medicine 2009, 49: 122-128. PMID: 19643125, PMCID: PMC2753673, DOI: 10.1016/j.ypmed.2009.07.014.Peer-Reviewed Original ResearchConceptsSchool-based interventionsInner-city youthStudentsEducational interventionSkills trainingMinority youthRisk youthCity youthMetabolic riskCoachingHealth coachingYouthType 2 diabetes mellitusType 2 diabetesSchoolsEducationDiabetes mellitusHigh riskDepressive symptomsAnthropometric measuresTrainingInterventionRiskGreater improvementMonthsTranslating the Diabetes Prevention Program to Primary Care
Whittemore R, Melkus G, Wagner J, Dziura J, Northrup V, Grey M. Translating the Diabetes Prevention Program to Primary Care. Nursing Research 2009, 58: 2-12. PMID: 19092550, PMCID: PMC2689783, DOI: 10.1097/nnr.0b013e31818fcef3.Peer-Reviewed Original ResearchMeSH KeywordsAdultDiabetes Mellitus, Type 2FemaleHumansHypercholesterolemiaHypertensionLife StyleMaleMiddle AgedNew EnglandNurse PractitionersNursing Evaluation ResearchNutritional SciencesObesityPatient Education as TopicPatient SatisfactionPilot ProjectsPrimary Health CareProgram EvaluationProspective StudiesSingle-Blind MethodConceptsStandard care participantsType 2 diabetesLifestyle programNurse practitionersHigh-density lipoproteinPrimary careCare participantsLifestyle change programDiabetes Prevention ProgramExercise behaviorMixed-model repeated-measures analysisRisk of diabetesStandard care programmeRepeated-measures analysisLifestyle participantsTreatment goalsCare programPrevention programsClinical settingPsychosocial strategiesDiabetesLow-income sampleWeight lossMotivational interviewingCare