2021
Outcome of COVID‐19 in Patients With Autoimmune Hepatitis: An International Multicenter Study
Efe C, Dhanasekaran R, Lammert C, Ebik B, la Tijera F, Aloman C, Calışkan A, Peralta M, Gerussi A, Massoumi H, Catana AM, Torgutalp M, Purnak T, Rigamonti C, Aldana A, Khakoo N, Kacmaz H, Nazal L, Frager S, Demir N, Irak K, Ellik ZM, Balaban Y, Atay K, Eren F, Cristoferi L, Batıbay E, Urzua Á, Snijders R, Kıyıcı M, Akyıldız M, Ekin N, Carr RM, Harputluoğlu M, Hatemi I, Mendizabal M, Silva M, Idilman R, Silveira M, Drenth JPH, Assis DN, Björnsson E, Boyer JL, Invernizzi P, Levy C, Schiano TD, Ridruejo E, Wahlin S. Outcome of COVID‐19 in Patients With Autoimmune Hepatitis: An International Multicenter Study. Hepatology 2021, 73: 2099-2109. PMID: 33713486, PMCID: PMC8250536, DOI: 10.1002/hep.31797.Peer-Reviewed Original ResearchConceptsSevere COVID-19Chronic liver diseaseAutoimmune hepatitisLiver injuryMulticenter studyCOVID-19Causes of CLDPropensity score-matched cohortSevere COVID-19 outcomesContinuation of immunosuppressionMaintenance of immunosuppressionOutcomes of patientsIntensive care admissionUse of antiviralsInternational multicenter studyCOVID-19 outcomesCOVID-19 diagnosisContinued immunosuppressionCare admissionCause mortalityIndependent predictorsMedian ageLiver diseaseMechanical ventilationRetrospective study
2017
Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis
Assis DN, Abdelghany O, Cai SY, Gossard AA, Eaton JE, Keach JC, Deng Y, Setchell KD, Ciarleglio M, Lindor KD, Boyer JL. Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis. Journal Of Clinical Gastroenterology 2017, 51: e11-e16. PMID: 27428727, PMCID: PMC5218875, DOI: 10.1097/mcg.0000000000000591.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAlanine TransaminaseAlkaline PhosphataseBile Acids and SaltsCholagogues and CholereticsCholangitis, SclerosingCholestenonesDrug Therapy, CombinationFemaleHumansLiverLiver Function TestsMaleMiddle AgedPilot ProjectsTreatment OutcomeTretinoinUrsodeoxycholic AcidYoung AdultConceptsPrimary sclerosing cholangitisUrsodeoxycholic acidAlanine aminotransferaseUDCA monotherapyPrimary endpointSclerosing cholangitisMedian serum alanine aminotransferasePilot studyWeeks of therapyMarkers of inflammationSerum alanine aminotransferaseRetinoic acidAlkaline phosphataseAll-Trans Retinoic AcidSerum ALP levelsHuman pilot studyCombination of ATRAAddition of ATRABile acid synthesisTrans retinoic acidExploratory pilot studyALT levelsAccepted therapyWeek 12C4 levels
1987
Improved survival with primary sclerosing cholangitis A review of clinicopathologic features and comparison of symptomatic and asymptomatic patients
Helzberg J, Petersen J, Boyer J. Improved survival with primary sclerosing cholangitis A review of clinicopathologic features and comparison of symptomatic and asymptomatic patients. Gastroenterology 1987, 92: 1869-1875. PMID: 3569762, DOI: 10.1016/0016-5085(87)90618-4.Peer-Reviewed Original ResearchConceptsPrimary sclerosing cholangitisIntrahepatic ductal systemSclerosing cholangitisClinicopathologic featuresDuctal systemKaplan-Meier life-table analysisLong-term prognosisGroup of patientsDifferent clinical characteristicsSerum bilirubin levelsOnset of diseaseUniversity Medical CenterLife-table analysisBiliary sclerosisAsymptomatic patientsPortal hypertensionClinical characteristicsLiver centersBilirubin levelsClinical featuresLiver diseaseMild diseasePoor prognosisMean ageFemale ratio
1981
Prognostic indicators of hepatic injury following jejunoileal bypass performed for refractory obesity: A prospective study
Haines N, Baker A, Boyer J, Glagov S, Schneir H, Jaspan J, Ferguson D. Prognostic indicators of hepatic injury following jejunoileal bypass performed for refractory obesity: A prospective study. Hepatology 1981, 1: 161-167. PMID: 7286895, DOI: 10.1002/hep.1840010212.Peer-Reviewed Original ResearchConceptsJejunoileal bypassInactive cirrhosisWeight lossHepatic injuryLiver biopsyPericentral fibrosisClinical liver failureOral nutritional supplementationAlcoholic liver diseaseSerum aspartate aminotransferaseGreater weight lossRapid weight lossCryptogenic cirrhosisRefractory obesityAsymptomatic patientsOlder patientsLiver failureLiver injuryLiver diseaseParenteral alimentationFatty infiltrationHistologic evidenceProspective studyPrognostic indicatorClinical evaluation