1998
Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo
Zheng T, Schlosser S, Dao T, Hingorani R, Crispe I, Boyer J, Flavell R. Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 13618-13623. PMID: 9811849, PMCID: PMC24868, DOI: 10.1073/pnas.95.23.13618.Peer-Reviewed Original ResearchConceptsCell deathDNA fragmentationFas-induced cell deathCaspase-3-like activityTypical apoptotic featuresCaspase-3NIH 3T3 cellsDFF45/ICADCaspase substratesApoptotic caspasesCaspase-1Apoptotic eventsApoptotic featuresCaspasesMorphological changesAberrant apoptosisNuclear eventsKey substrateNuclear fragmentationHepatocyte cell deathCytoplasmic blebbingApoptosisDifferent morphological changesAltered cleavageFA
1997
Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei
Setchell K, Rodrigues C, Clerici C, Solinas A, Morelli A, Gartung C, Boyer J. Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei. Gastroenterology 1997, 112: 226-235. PMID: 8978363, DOI: 10.1016/s0016-5085(97)70239-7.Peer-Reviewed Original ResearchConceptsBile acid concentrationsBile acid administrationBile duct ligationBile acid poolLiver tissueBile acidsAcid administrationRat liver tissueDuct ligationTotal bile acid concentrationTissue concentrationsBile acid compositionSham-operated ratsLiver tissue levelsMajor bile acidsHydrophobic bile acidsHepatocyte nucleiAcid poolHuman liver tissueExperimental cholestasisAbstractTextTissue levelsRat hepatic nucleiAcid concentrationAdministration