2006
The organic anion transport polypeptide 1d1 (Oatp1d1) mediates hepatocellular uptake of phalloidin and microcystin into skate liver
Meier-Abt F, Hammann-Hänni A, Stieger B, Ballatori N, Boyer J. The organic anion transport polypeptide 1d1 (Oatp1d1) mediates hepatocellular uptake of phalloidin and microcystin into skate liver. Toxicology And Applied Pharmacology 2006, 218: 274-279. PMID: 17198718, DOI: 10.1016/j.taap.2006.11.015.Peer-Reviewed Original ResearchConceptsSkate liverToxic liver injuryFunctional transport activityLiver-specific OATPsOrganic anion transporting polypeptidesLiver injuryOrganic anion transportersWater-injected oocytesXenobiotic toxinsHepatocellular uptakeBile saltsSkate hepatocytesOATP substratesHuman brainLiverPresent studyOatps/OATPsAnion transportersOATPDemethylphalloinHepatocytesTransport activityToxinCellular uptakeUptake
1995
Expression of sodium-independent organic anion uptake systems of skate liver in Xenopus laevis oocytes
Jacquemin E, Hagenbuch B, Wolkoff A, Meier P, Boyer J. Expression of sodium-independent organic anion uptake systems of skate liver in Xenopus laevis oocytes. American Journal Of Physiology 1995, 268: g18-g23. PMID: 7840202, DOI: 10.1152/ajpgi.1995.268.1.g18.Peer-Reviewed Original ResearchConceptsBSP uptakeSkate liverTaurocholate uptakeXenopus laevis oocytesOrganic anion transport systemInjection of oocytesLaevis oocytesLiverAnion transport systemRat liverSulfobromophthalein uptakeUptake systemOocytesMRNADisulfonic acidUptake activityFunctional expressionLiver mRNAUptakeExpressionSerum albuminLower vertebrates
1994
Characteristics of bile salt uptake into skate hepatocytes
Fricker G, Dubost V, Finsterwald K, Boyer J. Characteristics of bile salt uptake into skate hepatocytes. Biochemical Journal 1994, 299: 665-670. PMID: 8192655, PMCID: PMC1138072, DOI: 10.1042/bj2990665.Peer-Reviewed Original ResearchConceptsOrganic anion transport systemBile salt uptakeBile alcoholsBile saltsBeta-cholestane-3 alphaBile salt transportUnconjugated bile saltsTaurine-conjugated bile saltsHepatic uptakeAlpha-triolSkate bileInhibitory effectLiver cellsSkate hepatocytesIndependent transport systemsCholyltaurine transportCholyltaurineHepatocytesInhibitionAlphaUptakeSpecificity
1992
Taurine transport in skate hepatocytes. I. Uptake and efflux
Ballatori N, Boyer J. Taurine transport in skate hepatocytes. I. Uptake and efflux. American Journal Of Physiology 1992, 262: g445-g450. PMID: 1550234, DOI: 10.1152/ajpgi.1992.262.3.g445.Peer-Reviewed Original ResearchConceptsSkate hepatocytesDependent uptake processIntracellular taurine levelsTaurine uptake systemsTaurine levelsMicroM taurineTaurine uptakeIsosmotic replacementTaurine transportEfflux pathwaySlow effluxExtracellular ClIndependent uptake systemAmino sulfonic acidI. UptakeTaurine accumulationHepatocytesUptake systemEffluxTaurineDisulfonic acidBeta-amino acidsDistinct mechanismsUptakeReplacement
1988
Effect of l-alanine on membrane potential, potassium (86Rb) permeability and cell volume in hepatocytes from Raja erinacea
Ballatori N, Wondergem R, Boyer J. Effect of l-alanine on membrane potential, potassium (86Rb) permeability and cell volume in hepatocytes from Raja erinacea. Biochimica Et Biophysica Acta 1988, 946: 261-269. PMID: 3207743, DOI: 10.1016/0005-2736(88)90401-4.Peer-Reviewed Original ResearchCharacteristics of L-alanine uptake in freshly isolated hepatocytes of elasmobranch Raja erinacea
Ballatori N, Boyer J. Characteristics of L-alanine uptake in freshly isolated hepatocytes of elasmobranch Raja erinacea. American Journal Of Physiology 1988, 254: r801-r808. PMID: 3364608, DOI: 10.1152/ajpregu.1988.254.5.r801.Peer-Reviewed Original ResearchConceptsNeutral amino acid transport systemElasmobranch Raja erinaceaMajor gluconeogenic precursorMM alanineSodium-dependent systemAmino acid transport systemsRaja erinaceaHepatic uptakeHepatic concentrationsAcid transport systemL-alanine uptakeAminotransferase activityTumor cellsSpecific transport mechanismsMeAIB transportGluconeogenic precursorsSaturable mechanismSkate hepatocytesHepatocytesAlanine metabolismGlucose releaseMeAIBHepatocyte suspensionsRat hepatocytesUptake
1987
Anion transport in basolateral (sinusoidal) liver plasma-membrane vesicles of the little skate (Raja erinacea)
Hugentobler G, Fricker G, Boyer J, Meier P. Anion transport in basolateral (sinusoidal) liver plasma-membrane vesicles of the little skate (Raja erinacea). Biochemical Journal 1987, 247: 589-595. PMID: 3426551, PMCID: PMC1148453, DOI: 10.1042/bj2470589.Peer-Reviewed Original ResearchMeSH Keywords4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnimalsBiological TransportCarbonyl Cyanide m-Chlorophenyl HydrazoneCell MembraneCholic AcidCholic AcidsElectric FishHydrogen-Ion ConcentrationIn Vitro TechniquesLiverMaleProbenecidSkates, FishSulfatesConceptsPlasma membrane vesiclesBasolateral liver plasma membrane vesiclesSulfate uptakeLiver plasma membrane vesiclesProtonophore carbonyl cyanideSulfate transport systemVertebrate evolutionMammalian liver cellsPH-equilibrated conditionsTransmembrane transportPH gradientLittle skateRaja erinaceaUptake 5Carbonyl cyanideCI inhibitionAnion transport inhibitorAlkaline pH gradientVesiclesAnion transportSkate hepatocytesCertain organic anionsUptakeLiver cellsElasmobranchs
1985
The effect of ethanol and calcium on fluid state of plasma membranes of rat hepatocytes
Mills P, Meier P, Boyer J, Gordon E. The effect of ethanol and calcium on fluid state of plasma membranes of rat hepatocytes. Alcohol 1985, 2: 153-156. PMID: 4015830, DOI: 10.1016/0741-8329(85)90034-5.Peer-Reviewed Original ResearchConceptsMembrane protein functionProtein functionMembrane fluidityCanalicular plasma membrane vesiclesPlasma membrane vesiclesOverall cellular activityMembrane lipid fluidityPlasma membraneMembrane preparationsMembrane vesiclesCellular activitiesImportant regulatorLipid fluidityMembrane perturbantsFluorescence polarizationRat hepatocytesFluidityBlLPMRegulatorUptakeUptake of taurocholateVesiclesMillipore filtration technique
1976
Selective Hepatic Uptake and Biliary Excretion of 35S-Sulfobromophthalein in Marine Elasmobranchs
Boyer J, Schwarz J, Smith N. Selective Hepatic Uptake and Biliary Excretion of 35S-Sulfobromophthalein in Marine Elasmobranchs. Gastroenterology 1976, 70: 254-256. PMID: 1248686, DOI: 10.1016/s0016-5085(76)80019-4.Peer-Reviewed Original ResearchConceptsBinding proteinOrganic anion binding proteinMarine vertebratesHigher vertebratesSpecific binding proteinMarine elasmobranchsPhysiological significanceRaja erinaceaMarine lifeVertebratesElasmobranchsProteinTransport systemOrganic anionsErinaceaSpeciesSelective hepatic uptakeUptakeSkateSqualusDogfishMetabolismMigration