2006
The organic anion transport polypeptide 1d1 (Oatp1d1) mediates hepatocellular uptake of phalloidin and microcystin into skate liver
Meier-Abt F, Hammann-Hänni A, Stieger B, Ballatori N, Boyer J. The organic anion transport polypeptide 1d1 (Oatp1d1) mediates hepatocellular uptake of phalloidin and microcystin into skate liver. Toxicology And Applied Pharmacology 2006, 218: 274-279. PMID: 17198718, DOI: 10.1016/j.taap.2006.11.015.Peer-Reviewed Original ResearchConceptsSkate liverToxic liver injuryFunctional transport activityLiver-specific OATPsOrganic anion transporting polypeptidesLiver injuryOrganic anion transportersWater-injected oocytesXenobiotic toxinsHepatocellular uptakeBile saltsSkate hepatocytesOATP substratesHuman brainLiverPresent studyOatps/OATPsAnion transportersOATPDemethylphalloinHepatocytesTransport activityToxinCellular uptakeUptake
1999
Hepatic Toxicity and Persistence of ser/thr Protein Phosphatase Inhibition by Microcystin in the Little Skate Raja erinacea
Runnegar M, Seward D, Ballatori N, Crawford J, Boyer J. Hepatic Toxicity and Persistence of ser/thr Protein Phosphatase Inhibition by Microcystin in the Little Skate Raja erinacea. Toxicology And Applied Pharmacology 1999, 161: 40-49. PMID: 10558922, DOI: 10.1006/taap.1999.8783.Peer-Reviewed Original ResearchConceptsDose-dependent inhibitionSkate hepatocytesUptake of microcystinNear complete inhibitionPP activityInflammatory changesHepatic toxicityHepatocyte necrosisHistological changesAccompanying inhibitionHepatic lesionsBile acidsHigh dosesOnly organSignificant inhibitionSkate Raja erinaceaLittle skate Raja erinaceaInhibitionLiverRectal glandCarrier-mediated uptake of lucifer yellow in skate and rat hepatocytes: a fluid-phase marker revisited
Ballatori N, Hager D, Nundy S, Miller D, Boyer J. Carrier-mediated uptake of lucifer yellow in skate and rat hepatocytes: a fluid-phase marker revisited. American Journal Of Physiology 1999, 277: g896-g904. PMID: 10516157, DOI: 10.1152/ajpgi.1999.277.4.g896.Peer-Reviewed Original Research
1997
ATP regulation of a swelling‐activated osmolyte channel in skate hepatocytes
Ballatori N, Boyer J. ATP regulation of a swelling‐activated osmolyte channel in skate hepatocytes. Journal Of Experimental Zoology 1997, 279: 471-475. PMID: 9392868, DOI: 10.1002/(sici)1097-010x(19971201)279:5<471::aid-jez9>3.0.co;2-l.Peer-Reviewed Original ResearchConceptsChannel blockersTaurine effluxRegulatory volume decreaseVolume-activated taurine effluxRelease of taurineSkate hepatocytesIntracellular ATPIon channel blockersChloride permeability ratioIntracellular ATP levelsControl levelsOsmolyte channelIntracellular organic osmolytesWhole cell preparationsCell preparationsATP levelsBlockersHypotonic swellingChannel openingHepatocytesVolume decreaseAdditional mechanismEfflux
1995
ATP depletion and inactivation of an ATP-sensitive taurine channel by classic ion channel blockers.
Ballatori N, Truong A, Jackson P, Strange K, Boyer J. ATP depletion and inactivation of an ATP-sensitive taurine channel by classic ion channel blockers. Molecular Pharmacology 1995, 48: 472-6. PMID: 7565627.Peer-Reviewed Original ResearchConceptsIon channel blockersChannel blockersVolume-activated anion channelsATP levelsATP contentActivity of ATPPhysiologic alterationsIntracellular ATP levelsCellular ATPTaurine effluxBlockersIntracellular ATP contentTaurine channelCellular ATP levelsATP/ADP ratioIntracellular organic osmolytesSkate hepatocytesIntracellular ATPATP depletionCell volume regulationDifferent cell typesEffluxCellular ATP concentrationMetabolic poisonsCell types
1994
A volume-activated taurine channel in skate hepatocytes: membrane polarity and role of intracellular ATP
Ballatori N, Simmons T, Boyer J. A volume-activated taurine channel in skate hepatocytes: membrane polarity and role of intracellular ATP. American Journal Of Physiology 1994, 267: g285-g291. PMID: 7521136, DOI: 10.1152/ajpgi.1994.267.2.g285.Peer-Reviewed Original ResearchConceptsCell swellingSkate hepatocytesIntracellular ATPExtracellular taurine concentrationMetabolic inhibitorsSinusoidal circulationHypotonic stimuliTaurine concentrationsTaurine effluxTaurine uptakeIndependent uptakeTaurine channelSkate liverEfflux mechanismTaurineLiverHepatocytesInhibitorsEffluxBasolateral membraneOsmolyte taurineSwellingAntimycin ADisulfonic acidTransport inhibitorsCharacteristics of bile salt uptake into skate hepatocytes
Fricker G, Dubost V, Finsterwald K, Boyer J. Characteristics of bile salt uptake into skate hepatocytes. Biochemical Journal 1994, 299: 665-670. PMID: 8192655, PMCID: PMC1138072, DOI: 10.1042/bj2990665.Peer-Reviewed Original ResearchConceptsOrganic anion transport systemBile salt uptakeBile alcoholsBile saltsBeta-cholestane-3 alphaBile salt transportUnconjugated bile saltsTaurine-conjugated bile saltsHepatic uptakeAlpha-triolSkate bileInhibitory effectLiver cellsSkate hepatocytesIndependent transport systemsCholyltaurine transportCholyltaurineHepatocytesInhibitionAlphaUptakeSpecificity
1993
Characterization of bumetanide transport in isolated skate hepatocytes
Blumrich M, Petzinger E, Boyer J. Characterization of bumetanide transport in isolated skate hepatocytes. American Journal Of Physiology 1993, 265: g926-g933. PMID: 8238522, DOI: 10.1152/ajpgi.1993.265.5.g926.Peer-Reviewed Original Research
1992
Taurine transport in skate hepatocytes. I. Uptake and efflux
Ballatori N, Boyer J. Taurine transport in skate hepatocytes. I. Uptake and efflux. American Journal Of Physiology 1992, 262: g445-g450. PMID: 1550234, DOI: 10.1152/ajpgi.1992.262.3.g445.Peer-Reviewed Original ResearchConceptsSkate hepatocytesDependent uptake processIntracellular taurine levelsTaurine uptake systemsTaurine levelsMicroM taurineTaurine uptakeIsosmotic replacementTaurine transportEfflux pathwaySlow effluxExtracellular ClIndependent uptake systemAmino sulfonic acidI. UptakeTaurine accumulationHepatocytesUptake systemEffluxTaurineDisulfonic acidBeta-amino acidsDistinct mechanismsUptakeReplacement
1988
Effect of l-alanine on membrane potential, potassium (86Rb) permeability and cell volume in hepatocytes from Raja erinacea
Ballatori N, Wondergem R, Boyer J. Effect of l-alanine on membrane potential, potassium (86Rb) permeability and cell volume in hepatocytes from Raja erinacea. Biochimica Et Biophysica Acta 1988, 946: 261-269. PMID: 3207743, DOI: 10.1016/0005-2736(88)90401-4.Peer-Reviewed Original ResearchCharacteristics of L-alanine uptake in freshly isolated hepatocytes of elasmobranch Raja erinacea
Ballatori N, Boyer J. Characteristics of L-alanine uptake in freshly isolated hepatocytes of elasmobranch Raja erinacea. American Journal Of Physiology 1988, 254: r801-r808. PMID: 3364608, DOI: 10.1152/ajpregu.1988.254.5.r801.Peer-Reviewed Original ResearchConceptsNeutral amino acid transport systemElasmobranch Raja erinaceaMajor gluconeogenic precursorMM alanineSodium-dependent systemAmino acid transport systemsRaja erinaceaHepatic uptakeHepatic concentrationsAcid transport systemL-alanine uptakeAminotransferase activityTumor cellsSpecific transport mechanismsMeAIB transportGluconeogenic precursorsSaturable mechanismSkate hepatocytesHepatocytesAlanine metabolismGlucose releaseMeAIBHepatocyte suspensionsRat hepatocytesUptake
1987
Identification of a single sinusoidal bile salt uptake system in skate liver
Fricker G, Hugentobler G, Meier P, Kurz G, Boyer J. Identification of a single sinusoidal bile salt uptake system in skate liver. American Journal Of Physiology 1987, 253: g816-g822. PMID: 3425718, DOI: 10.1152/ajpgi.1987.253.6.g816.Peer-Reviewed Original ResearchConceptsBile salt uptakeSkate liverAlpha-dihydroxy-5 betaBile salt derivativesAzo-3 alphaBile acid uptakeConcentration-dependent mannerPredominant bile saltHepatic uptakePhotolabile bile salt derivativeIndependent transport mechanismsAcid uptakeLiverApparent molecular weightBile saltsRat liverTaurocholate uptakeSkate hepatocytesAnion transport inhibitorUptake systemHepatocytesPhotoaffinity labelingTaurocholateDisulfonic acidIrreversible inhibitionAnion transport in basolateral (sinusoidal) liver plasma-membrane vesicles of the little skate (Raja erinacea)
Hugentobler G, Fricker G, Boyer J, Meier P. Anion transport in basolateral (sinusoidal) liver plasma-membrane vesicles of the little skate (Raja erinacea). Biochemical Journal 1987, 247: 589-595. PMID: 3426551, PMCID: PMC1148453, DOI: 10.1042/bj2470589.Peer-Reviewed Original ResearchMeSH Keywords4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnimalsBiological TransportCarbonyl Cyanide m-Chlorophenyl HydrazoneCell MembraneCholic AcidCholic AcidsElectric FishHydrogen-Ion ConcentrationIn Vitro TechniquesLiverMaleProbenecidSkates, FishSulfatesConceptsPlasma membrane vesiclesBasolateral liver plasma membrane vesiclesSulfate uptakeLiver plasma membrane vesiclesProtonophore carbonyl cyanideSulfate transport systemVertebrate evolutionMammalian liver cellsPH-equilibrated conditionsTransmembrane transportPH gradientLittle skateRaja erinaceaUptake 5Carbonyl cyanideCI inhibitionAnion transport inhibitorAlkaline pH gradientVesiclesAnion transportSkate hepatocytesCertain organic anionsUptakeLiver cellsElasmobranchsTaurocholate uptake by isolated skate hepatocytes: effect of albumin
Smith D, Grossbard M, Gordon E, Boyer J. Taurocholate uptake by isolated skate hepatocytes: effect of albumin. American Journal Of Physiology 1987, 252: g479-g484. PMID: 3565567, DOI: 10.1152/ajpgi.1987.252.4.g479.Peer-Reviewed Original Research