1989
Hepatic immunohistochemical localization of the tight junction protein ZO-1 in rat models of cholestasis.
Anderson J, Glade J, Stevenson B, Boyer J, Mooseker M. Hepatic immunohistochemical localization of the tight junction protein ZO-1 in rat models of cholestasis. American Journal Of Pathology 1989, 134: 1055-62. PMID: 2719075, PMCID: PMC1879891.Peer-Reviewed Original ResearchConceptsZO-1 proteinZO-1Tight junctionsConsecutive daily subcutaneous injectionsFrozen sectionsReflux of bileDaily subcutaneous injectionsBile duct obstructionCommon bile ductMale Sprague-DawleyHepatocyte tight junctionsBile duct ligation resultsTight junction protein ZO-1Cholestatic modelsDuct obstructionBile ductSubcutaneous injectionCholestatic liverRat modelEthinyl estradiolSprague-DawleyProtein ZO-1Immunoperoxidase stainingZO-1 stainingImmunohistochemical localization
1986
Intrabiliary glutathione hydrolysis. A source of glutamate in bile.
Ballatori N, Jacob R, Boyer J. Intrabiliary glutathione hydrolysis. A source of glutamate in bile. Journal Of Biological Chemistry 1986, 261: 7860-7865. PMID: 2872220, DOI: 10.1016/s0021-9258(19)57482-8.Peer-Reviewed Original ResearchConceptsGamma-glutamyl transferase activityBiliary excretionRat bileRetrograde intrabiliary infusionAT-125Normal male Sprague-DawleyAdministration of phenolMale Sprague-DawleyNormal rat bileDihydro-5-isoxazoleacetic acidSource of glutamateIntrabiliary infusionRate of excretionDibromphthalein disulfonateBranched chain amino acids valineBiliary treeSprague-DawleyDiethyl maleateBileExcretionTransferase activityGSH secretionLiver cellsMarked decreaseExcretion of glutamate