1999
Hepatic sequestration and modulation of the canalicular transport of the organic cation, daunorubicin, in the rat
Hayes J, Soroka C, Rios‐Velez L, Boyer J. Hepatic sequestration and modulation of the canalicular transport of the organic cation, daunorubicin, in the rat. Hepatology 1999, 29: 483-493. PMID: 9918926, DOI: 10.1002/hep.510290216.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Bacterial AgentsAntineoplastic AgentsATP Binding Cassette Transporter, Subfamily B, Member 1BileBile CanaliculiBiological TransportBucladesineCationsChloroquineDaunorubicinKineticsLiverMacrolidesMaleMitochondrial ProteinsNocodazoleRatsRats, WistarRibosomal ProteinsSaccharomyces cerevisiae ProteinsTaurocholic AcidVerapamilConceptsBiliary excretionCoadministration of verapamilInhibitors of MDR1Rat hepatocyte coupletsBiliary recoveryDose administeredHepatic sequestrationTR- mutant ratsTherapeutic agentsExcretionDaunorubicinPericanalicular regionHepatocyte coupletsCanalicular transportRat liverBafilomycin ATaurocholateRatsIPRLIntracellular acidic compartmentsCellular localizationMicrotubule destabilizerConfocal microscopyIRHCPattern of distribution
1991
Effect of UDCA on intracellular and biliary pH in isolated rat hepatocyte couplets and perfused livers
Strazzabosco M, Sakisaka S, Hayakawa T, Boyer J. Effect of UDCA on intracellular and biliary pH in isolated rat hepatocyte couplets and perfused livers. American Journal Of Physiology 1991, 260: g58-g69. PMID: 1987808, DOI: 10.1152/ajpgi.1991.260.1.g58.Peer-Reviewed Original ResearchConceptsBiliary HCO3- concentrationUrsodeoxycholic acidRat hepatocyte coupletsBiliary pHAcid loadEffect of UDCABile duct lumenHepatocyte coupletsIsolated rat hepatocyte coupletsBiliary epitheliumHCO3- concentrationDuct lumenRemoval of ClHCO3- exchangeRat liverLiverIPRLHepatocytesHypercholeresisPerfusateBileExcretionEpitheliumAmiloride