2024
Development and comparison of immunologic assays to detect primary RSV infections in infants
Anderson L, Jadhao S, Hussaini L, Ha B, McCracken C, Gibson T, Yildirim I, Yi J, Stephens K, Korski C, Kao C, Sun H, Lee C, Jaunarajs A, Rostad C, Anderson E. Development and comparison of immunologic assays to detect primary RSV infections in infants. Frontiers In Immunology 2024, 14: 1332772. PMID: 38283339, PMCID: PMC10811012, DOI: 10.3389/fimmu.2023.1332772.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusIgG enzyme immunoassayNeutralizing antibody assaysELISPOT assayAntibody assayRSV antibodiesEnzyme immunoassayRSV infectionSubgroup ARespiratory syncytial virus seasonDocumented RSV infectionPrimary RSV infectionEffective respiratory syncytial virusVaccine clinical trialsEvidence of past infectionEpidemiological studiesRed cell lysisYoung childrenMaternal microchimerismPBMC specimensPregnant womenIFN-gSyncytial virusAntibody enzyme immunoassayELISPOT
2021
Respiratory Syncytial Virus–Associated Mortality Among Young Infants in Karachi, Pakistan: A Prospective Postmortem Surveillance Study
Kazi AM, Aguolu OG, Mughis W, Ahsan N, Jamal S, Khan A, Qureshi HM, Yildirim I, Malik FA, Omer SB. Respiratory Syncytial Virus–Associated Mortality Among Young Infants in Karachi, Pakistan: A Prospective Postmortem Surveillance Study. Clinical Infectious Diseases 2021, 73: s203-s209. PMID: 34472574, PMCID: PMC8411247, DOI: 10.1093/cid/ciab488.Peer-Reviewed Original ResearchMeSH KeywordsAutopsyFemaleHumansInfantInfant, NewbornMalePakistanPregnancyProspective StudiesRespiratory Syncytial Virus InfectionsRespiratory Syncytial Virus, HumanConceptsRespiratory syncytial virusRespiratory symptomsInfant deathRSV seasonalityRole of RSVYoung infantsPresence of RSVMultivariable logistic regression analysisMaternal immunization strategiesSignificant mortality burdenVaccine-hesitant populationYoung infant deathsMultivariable logistic regressionCold-like symptomsSignificant predictorsLogistic regression analysisPostneonatal ageRSV mortalityRSV seasonMaternal immunizationInfant morbidityNasopharyngeal specimensNasopharyngeal swabsSyncytial virusRespiratory illness
2020
The burden of respiratory syncytial virus infections among children with sickle cell disease
Rostad CA, Maillis AN, Lai K, Bakshi N, Jerris RC, Lane PA, Yee ME, Yildirim I. The burden of respiratory syncytial virus infections among children with sickle cell disease. Pediatric Blood & Cancer 2020, 68: e28759. PMID: 33034160, PMCID: PMC8246443, DOI: 10.1002/pbc.28759.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusSickle cell diseaseRespiratory viral panelRSV-positive casesRSV infectionAnnual incidenceHospitalization ratesCell diseaseBurden of RSVPediatric lower respiratory tract infectionsLaboratory-confirmed RSV infectionRespiratory syncytial virus infectionRSV-related hospitalization rateLower respiratory tract infectionsRSV positive testRSV-negative childrenRSV-negative patientsAcute chest syndromeSyncytial virus infectionRespiratory tract infectionsAverage annual incidenceMultivariate logistic regressionConfidence intervalsCase-control studyOutcome of children
2019
Assessment and Validation of Syndromic Case Definitions for Respiratory Syncytial Virus Infections in Young Infants: A Latent Class Analysis.
Lalani K, Yildirim I, Phadke VK, Bednarczyk RA, Omer SB. Assessment and Validation of Syndromic Case Definitions for Respiratory Syncytial Virus Infections in Young Infants: A Latent Class Analysis. The Pediatric Infectious Disease Journal 2019, 38: 1177-1182. PMID: 31568250, DOI: 10.1097/inf.0000000000002468.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusSyndromic case definitionsCase definitionYoung infantsWorld Health OrganizationRSV infectionLatent class analysisPredictive valueLaboratory-confirmed RSV infectionRespiratory syncytial virus infectionSyncytial virus infectionAcute respiratory infectionsHigh positive predictive valueRoutine clinical careStandardized case definitionsHigh-resource settingsAppropriate case definitionsHigh-income settingsNegative predictive valueMonths of agePositive predictive valueRespiratory infectionsVaccine evaluationClinical featuresPediatric morbidity
2018
Assessment and Validation of Syndromic Case definitions for Respiratory Syncytial Virus Testing in a Low Resource Population
Omer SB, Bednarczyk R, Kazi M, Guterman LB, Aziz F, Allen KE, Yildirim I, Ali SA. Assessment and Validation of Syndromic Case definitions for Respiratory Syncytial Virus Testing in a Low Resource Population. The Pediatric Infectious Disease Journal 2018, Publish Ahead of Print: &na;. PMID: 30074977, PMCID: PMC6437080, DOI: 10.1097/inf.0000000000002159.Peer-Reviewed Original ResearchMeSH KeywordsHealth ResourcesHumansInfantNasopharynxPakistanPopulation SurveillanceProspective StudiesPublic HealthRespiratory Syncytial Virus InfectionsRespiratory Syncytial Virus, HumanConceptsCommunity-based surveillanceCase definitionRespiratory syncytial virus testingRespiratory syncytial virus infectionSyncytial virus infectionLow-resource populationsStandardized case definitionsSyndromic case definitionsResource-limited settingsVaccine evaluationVirus infectionVirus testingYoung infantsVirus control strategiesModest specificitySurveillanceCyanosisWheezeApneaInfantsInfection