2023
Incidence of cytomegalovirus DNAemia in pediatric kidney, liver, and heart transplant recipients: Efficacy and risk factors associated with failure of weight‐based dosed valganciclovir prophylaxis
Liverman R, Serluco A, Nance G, George R, Rodriguez D, Deshpande S, Mao C, Garro R, Yildirim I. Incidence of cytomegalovirus DNAemia in pediatric kidney, liver, and heart transplant recipients: Efficacy and risk factors associated with failure of weight‐based dosed valganciclovir prophylaxis. Pediatric Transplantation 2023, 27: e14493. PMID: 36945819, DOI: 10.1111/petr.14493.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsPediatric solid organ transplant recipientsCytomegalovirus DNAemiaValganciclovir prophylaxisDose reductionRisk factorsTransplant recipientsImpact of dose adjustmentsRisk factors associated with failureFactors associated with failureOrgan transplant recipientsHeart transplant recipientsIndependent risk factorRetrospective cohort studyAssociated with morbidityCMV DNAemiaCytomegalovirus eventsValganciclovir dosingImmunosuppressive therapyDose adjustmentYounger age groupsDNAemiaValganciclovirRisk stratificationAdverse events
2020
Urinary Tract Infections With Extended-spectrum-β-lactamase-producing Bacteria: Case-control Study.
Amin O, Prestel C, Gonzalez MD, Lyon T, Shane A, Jaggi P, Tippett A, Yildirim I. Urinary Tract Infections With Extended-spectrum-β-lactamase-producing Bacteria: Case-control Study. The Pediatric Infectious Disease Journal 2020, 39: 211-216. PMID: 32032306, DOI: 10.1097/inf.0000000000002531.Peer-Reviewed Original ResearchConceptsUrinary tract infectionESBL-producing bacteriaCase-control studyRisk factorsTract infectionsPrior intensive care unit admissionIntensive care unit admissionPediatric urinary tract infectionCause of UTIClinical signs/symptomsCare unit admissionIndependent risk factorYear of diagnosisΒ-lactamase-producing bacteriaSigns/symptomsCommon bacterial infectionsSpectrum β-lactamasesRational antimicrobial useESBL casesESBL-UTIUnit admissionUnderlying comorbiditiesPrior hospitalizationEmpirical therapyPediatric patients