1990
Regulation of surfactant protein A mRNA by hormones and butyrate in cultured fetal rat lung
Nichols K, Floros J, Dynia D, Veletza S, Wilson C, Gross I. Regulation of surfactant protein A mRNA by hormones and butyrate in cultured fetal rat lung. American Journal Of Physiology 1990, 259: l488-l495. PMID: 2175559, DOI: 10.1152/ajplung.1990.259.6.l488.Peer-Reviewed Original Research8-Bromo Cyclic Adenosine MonophosphateAnimalsBucladesineButyratesButyric AcidDexamethasoneFetusGene Expression RegulationGlycoproteinsLungOrgan Culture TechniquesPhospholipidsProteolipidsPulmonary Surfactant-Associated Protein APulmonary Surfactant-Associated ProteinsPulmonary SurfactantsRatsRNA ProbesRNA, MessengerTriiodothyronine
1988
Activities of enzymes of phospholipid and fatty acid synthesis in fetal and adult rat type II pneumocytes
Kresch M, Smart D, Wilson C, Gross I, Rooney S. Activities of enzymes of phospholipid and fatty acid synthesis in fetal and adult rat type II pneumocytes. Biochimica Et Biophysica Acta 1988, 962: 173-177. PMID: 2844273, DOI: 10.1016/0005-2760(88)90156-7.Peer-Reviewed Original Research
1983
Fetal rat lung maturation: initiation and modulation
Gross I, Wilson C. Fetal rat lung maturation: initiation and modulation. Journal Of Applied Physiology 1983, 55: 1725-1732. PMID: 6662763, DOI: 10.1152/jappl.1983.55.6.1725.Peer-Reviewed Original ResearchConceptsFetal lung maturationGestational ageLung maturationCholine incorporationEquivalent gestational ageFetal rat lungGlucocorticoid bindingDays gestationLung tissueFetal lungRat lungBiochemical markersLung developmentMorphological maturationDSPC contentMesenchymal tissueMaturational processesMarked increaseHormoneSimilar increaseLungLate modulationPhosphatidylcholine synthesisAgeMaturation
1981
Organotypic Culture of Fetal Rat Lung: Evaluation and Comparison with Organ Culture1–3
Gross I, Freedman R, Wilson C, Lindsey S. Organotypic Culture of Fetal Rat Lung: Evaluation and Comparison with Organ Culture1–3. American Journal Of Respiratory And Critical Care Medicine 1981, 123: 313-9. PMID: 7224342, DOI: 10.1164/arrd.1981.123.3.313.Peer-Reviewed Original Research
1980
The Influence of Hormones on the Biochemical Development of Fetal Rat Lung in Organ Culture. II. Insulin
Gross I, Walker Smith G, Wilson C, Maniscalco W, Ingleson L, Brehier A, Rooney S. The Influence of Hormones on the Biochemical Development of Fetal Rat Lung in Organ Culture. II. Insulin. Pediatric Research 1980, 14: 834-838. PMID: 6995921, DOI: 10.1203/00006450-198006000-00012.Peer-Reviewed Original ResearchConceptsFetal rat lungRat lungCholine incorporationSignificant decreasePhospholipid fractionInfluence of insulinEffect of insulinInfluence of hormonesPercentage of radioactivityType II cellsLung cell growthLung cell differentiationLung maturationOrgan culture systemInsulin treatmentMorphologic evidencePhospholipid radioactivityInsulinMorphologic maturationSurfactant phospholipidsGlycogen contentII cellsOrgan cultureBiochemical developmentLamellar bodiesFetal lung in organ culture. III. Comparison of dexamethasone, thyroxine, and methylxanthines
Gross I, Wilson C, Ingleson L, Brehier A, Rooney S. Fetal lung in organ culture. III. Comparison of dexamethasone, thyroxine, and methylxanthines. Journal Of Applied Physiology 1980, 48: 872-877. PMID: 7451297, DOI: 10.1152/jappl.1980.48.5.872.Peer-Reviewed Original ResearchConceptsFetal lungComparison of dexamethasoneLung glycogen contentSurfactant-associated phospholipidsFetal rat lungPercentage of radioactivityRat lungAminophyllineCholine-containing phospholipidsThyroxineGlycogen contentCholine incorporationLungCaffeine treatmentSignificant decreaseOrgan cultureRate of incorporationSignificant increaseLysolecithin acyltransferaseExposure of explantsCholinephosphate cytidylyltransferaseDexamethasoneDifferent effectsMembrane phospholipidsMethylxanthines
1979
The influence of hormones on the biochemical development of fetal rat lung in organ culture I. Estrogen
Gross I, Wilson C, Ingleson L, Brehier A, Rooney S. The influence of hormones on the biochemical development of fetal rat lung in organ culture I. Estrogen. Biochimica Et Biophysica Acta 1979, 575: 375-383. PMID: 518894, DOI: 10.1016/0005-2760(79)90106-1.Peer-Reviewed Original ResearchConceptsFetal rat lungPercentage of radioactivityEstrogen actsFetal lungRat lungPhospholipid fractionInfluence of hormonesProtein/DNA ratioEstrogen treatmentIncorporation of cholineLungGlycogen contentTotal phospholipidsOrgan cultureSignificant stimulationPulmonary surfactantBiochemical developmentIndividual phospholipidsPhosphatidylcholine synthesisSignificant changesPhospholipid synthesisPhospholipidsAbundant phospholipidDNA ratioRadioactivityThe Hormonal Regulation of Fetal Lung Maturation
Gross I. The Hormonal Regulation of Fetal Lung Maturation. Clinics In Perinatology 1979, 6: 377-395. PMID: 230006, DOI: 10.1016/s0095-5108(18)31155-2.ChaptersEffects of betamethasone on phospholipid content, composition and biosynthesis in the fetal rabbit lung
Rooney S, Gobran L, Marino P, Maniscalco W, Gross I. Effects of betamethasone on phospholipid content, composition and biosynthesis in the fetal rabbit lung. Biochimica Et Biophysica Acta 1979, 572: 64-76. PMID: 216408, DOI: 10.1016/0005-2760(79)90200-5.Peer-Reviewed Original ResearchConceptsLung lavageFetal lung lavageFetal lung slicesAdministration of betamethasoneEffect of betamethasoneFetal lung maturationFetal rabbit lungPhosphatidylcholine/sphingomyelin ratioLung glycogenBetamethasone administrationLung maturationPregnant rabbitsDays gestationFetal lungLung slicesRabbit lungsStress-induced accelerationDirect administrationSphingomyelin ratioSurfactant phospholipidsBetamethasoneAdministrationRate of incorporationSurfactant productionLavage
1978
Development of glycogen and phospholipid metabolism in fetal and newborn rat lung
Maniscalco W, Wilson C, Gross I, Gobran L, Rooney S, Warshaw J. Development of glycogen and phospholipid metabolism in fetal and newborn rat lung. Biochimica Et Biophysica Acta 1978, 530: 333-346. PMID: 100141, DOI: 10.1016/0005-2760(78)90153-4.Peer-Reviewed Original ResearchConceptsNewborn rat lungGlycogen phosphorylase activityFetal lungRat lungGlycogen concentrationFetal lung glycogenFirst postnatal dayPhosphorylase activityTotal glycogen synthaseTotal glycogen phosphorylase activityMajor metabolic substratesLung glycogenPhosphatidylcholine synthesisGlycogen synthase activityIncorporation of cholinePostnatal dayGlycogen depletionDay 19LungGestationDay 20Adult lungMammalian fetusGlycogen contentTotal phospholipidsPhosphatidylcholine synthesis in newborn rabbit lung developmental pattern and the influence of nutrition
Gross I, Wilson C, Rooney S. Phosphatidylcholine synthesis in newborn rabbit lung developmental pattern and the influence of nutrition. Biochimica Et Biophysica Acta 1978, 528: 190-198. PMID: 623776, DOI: 10.1016/0005-2760(78)90193-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornFastingLungPhosphatidylcholinesPhospholipidsRabbitsSphingomyelinsConceptsLung lavage
1977
Aminophylline stimulates the incorporation of choline into phospholipid in explants of fetal rat lung in organ culture
Gross I, Rooney S. Aminophylline stimulates the incorporation of choline into phospholipid in explants of fetal rat lung in organ culture. Biochimica Et Biophysica Acta 1977, 488: 263-269. PMID: 196659, DOI: 10.1016/0005-2760(77)90183-7.Peer-Reviewed Original ResearchConceptsFetal rat lungRat lungCholine incorporationIncorporation of cholineCyclic AMPCyclic AMP phosphodiesterase inhibitorDirect stimulatory effectOrgan cultureF12 mediumAminophylline treatmentDibutyryl cyclic AMPMM aminophyllinePhosphodiesterase inhibitorAminophyllineLungStimulatory effectSimilar changesAMPStimulationDirect effectSmall increaseCholine kinaseCholineExposurePhospholipids
1976
Studies on pulmonary surfactant Effects of cortisol administration to fetal rabbits on lung phospholipid content, composition and biosynthesis
Rooney S, Gobran L, Gross I, Wai-Lee T, Nardone L, Motoyama E. Studies on pulmonary surfactant Effects of cortisol administration to fetal rabbits on lung phospholipid content, composition and biosynthesis. Biochimica Et Biophysica Acta 1976, 450: 121-130. PMID: 186118, DOI: 10.1016/0005-2760(76)90083-7.Peer-Reviewed Original ResearchMeSH Keywords1-Acylglycerophosphocholine O-AcyltransferaseAnimalsCholine KinaseCytidine Diphosphate CholineDiacylglycerol CholinephosphotransferaseFatty AcidsFemaleFetusGestational AgeGlycerolHydrocortisoneLungNucleotidyltransferasesPhosphatidylcholinesPhospholipidsPregnancyPulmonary SurfactantsRabbitsConceptsLung lavageCortisol administrationDays gestationFetal rabbitsUntreated fetusesLung phospholipid contentGreater gestational ageSaline-injected controlsLysolecithin acyltransferasePhospholipid contentGestational ageIntrauterine injectionLung tissueSaline injectionFetal lungMaturational effectsGestationFetusesLavageMajor surface-active componentAdministrationCorticosteroidsCholinephosphate cytidylyltransferaseSynthesis of phosphatidylcholineHormoneThe influence of postnatal nutritional deprivation on the phospholipid content of developing rat lung
Gross I, Ilic I, Wilson C, Rooney S. The influence of postnatal nutritional deprivation on the phospholipid content of developing rat lung. Biochimica Et Biophysica Acta 1976, 441: 412-422. PMID: 9987, DOI: 10.1016/0005-2760(76)90238-1.Peer-Reviewed Original ResearchConceptsLung cell numberLung lavage phospholipidPostnatal nutritional deprivationTotal phospholipidsStandard rat chowLung protein contentPhosphatidylcholine contentRole of nutritionLung phospholipid synthesisFat-fed animalsLung surfactant productionLavage phospholipidsGlucose-fed groupRat chowLung lavageLung tissueDietary regimensMicrosomal fatty acid elongationRat lungLung proteinFasted animalsProtein dietLungNutritional deprivationAcetyl-CoA carboxylase
1975
Stimulation of glycerolphosphate phosphatidyltransferase activity in fetal rabbit lung by cortisol administration
Rooney S, Gross I, Gassenheimer L, Motoyama E. Stimulation of glycerolphosphate phosphatidyltransferase activity in fetal rabbit lung by cortisol administration. Biochimica Et Biophysica Acta 1975, 398: 433-441. PMID: 1242106, DOI: 10.1016/0005-2760(75)90194-0.Peer-Reviewed Original ResearchConceptsAdministration of cortisolFetal rabbit lungLysolecithin acyltransferase activityLung maturationLiver enzymesDays gestationFetal rabbitsThyroxine treatmentGestation resultsCortisol administrationRabbit lungsCortisol treatmentDirect administrationAdministrationPulmonary surfactantSurfactant productionSignificant increaseGestationCholine phosphotransferaseAcyltransferase activityTreatmentCorticosteroidsPrevious studiesLungFetusesThe inhibition of enzymes related to pulmonary fatty acid and phospholipid synthesis by dietary deprivation in the rat
Gross I, Rooney S, Warshaw J. The inhibition of enzymes related to pulmonary fatty acid and phospholipid synthesis by dietary deprivation in the rat. Biochemical And Biophysical Research Communications 1975, 64: 59-63. PMID: 238512, DOI: 10.1016/0006-291x(75)90219-3.Peer-Reviewed Original ResearchConceptsPulmonary surfactant productionMicrosomal fatty acid elongationDietary deprivationRat lungFatty acid synthetaseDeprivation resultsAcute starvationInhibition of enzymesAcetyl-CoA carboxylaseSurfactant productionKnown inhibitionSignificant reductionFatty acid elongationFatty acidsInhibitionPhospholipid synthesisLung