1983
Lung surfactant in the hyperinsulinemic fetal monkey
Rooney S, Chu A, Gross I, Marino P, Schwartz R, Seghal P, Singer D, Susa J, Warshaw J, Wilson C. Lung surfactant in the hyperinsulinemic fetal monkey. Lung 1983, 161: 313-317. PMID: 6355669, DOI: 10.1007/bf02713877.Peer-Reviewed Original ResearchConceptsAbsence of hyperglycemiaBlood insulin levelsFetal rhesus monkeysEffect of hyperinsulinemiaInfusion of insulinSurfactant productionLung surfactant productionDiabetic mothersAlzet minipumpsInsulin levelsD gestationFetal monkeysFetal primateLung lavageLung tissueDays gestationLung slicesBody weightControl groupRhesus monkeysHyperinsulinemiaGestationCholine incorporationInhibitory effectHuman infants
1978
Development of glycogen and phospholipid metabolism in fetal and newborn rat lung
Maniscalco W, Wilson C, Gross I, Gobran L, Rooney S, Warshaw J. Development of glycogen and phospholipid metabolism in fetal and newborn rat lung. Biochimica Et Biophysica Acta 1978, 530: 333-346. PMID: 100141, DOI: 10.1016/0005-2760(78)90153-4.Peer-Reviewed Original ResearchConceptsNewborn rat lungGlycogen phosphorylase activityFetal lungRat lungGlycogen concentrationFetal lung glycogenFirst postnatal dayPhosphorylase activityTotal glycogen synthaseTotal glycogen phosphorylase activityMajor metabolic substratesLung glycogenPhosphatidylcholine synthesisGlycogen synthase activityIncorporation of cholinePostnatal dayGlycogen depletionDay 19LungGestationDay 20Adult lungMammalian fetusGlycogen contentTotal phospholipids
1976
Studies on pulmonary surfactant Effects of cortisol administration to fetal rabbits on lung phospholipid content, composition and biosynthesis
Rooney S, Gobran L, Gross I, Wai-Lee T, Nardone L, Motoyama E. Studies on pulmonary surfactant Effects of cortisol administration to fetal rabbits on lung phospholipid content, composition and biosynthesis. Biochimica Et Biophysica Acta 1976, 450: 121-130. PMID: 186118, DOI: 10.1016/0005-2760(76)90083-7.Peer-Reviewed Original ResearchMeSH Keywords1-Acylglycerophosphocholine O-AcyltransferaseAnimalsCholine KinaseCytidine Diphosphate CholineDiacylglycerol CholinephosphotransferaseFatty AcidsFemaleFetusGestational AgeGlycerolHydrocortisoneLungNucleotidyltransferasesPhosphatidylcholinesPhospholipidsPregnancyPulmonary SurfactantsRabbitsConceptsLung lavageCortisol administrationDays gestationFetal rabbitsUntreated fetusesLung phospholipid contentGreater gestational ageSaline-injected controlsLysolecithin acyltransferasePhospholipid contentGestational ageIntrauterine injectionLung tissueSaline injectionFetal lungMaturational effectsGestationFetusesLavageMajor surface-active componentAdministrationCorticosteroidsCholinephosphate cytidylyltransferaseSynthesis of phosphatidylcholineHormone
1975
Stimulation of glycerolphosphate phosphatidyltransferase activity in fetal rabbit lung by cortisol administration
Rooney S, Gross I, Gassenheimer L, Motoyama E. Stimulation of glycerolphosphate phosphatidyltransferase activity in fetal rabbit lung by cortisol administration. Biochimica Et Biophysica Acta 1975, 398: 433-441. PMID: 1242106, DOI: 10.1016/0005-2760(75)90194-0.Peer-Reviewed Original ResearchConceptsAdministration of cortisolFetal rabbit lungLysolecithin acyltransferase activityLung maturationLiver enzymesDays gestationFetal rabbitsThyroxine treatmentGestation resultsCortisol administrationRabbit lungsCortisol treatmentDirect administrationAdministrationPulmonary surfactantSurfactant productionSignificant increaseGestationCholine phosphotransferaseAcyltransferase activityTreatmentCorticosteroidsPrevious studiesLungFetuses