Featured Publications
Leveraging LD eigenvalue regression to improve the estimation of SNP heritability and confounding inflation
Song S, Jiang W, Zhang Y, Hou L, Zhao H. Leveraging LD eigenvalue regression to improve the estimation of SNP heritability and confounding inflation. American Journal Of Human Genetics 2022, 109: 802-811. PMID: 35421325, PMCID: PMC9118121, DOI: 10.1016/j.ajhg.2022.03.013.Peer-Reviewed Original ResearchConceptsLinkage disequilibrium score regressionComplex traitsSingle nucleotide polymorphismsSNP heritabilityGenome-wide association studiesDisequilibrium score regressionHigh-throughput technologiesHeritable phenotypesAssociation studiesGenetic studiesCryptic relatednessLD informationScore regressionHeritabilityGenetic contributionHeritability estimationPopulation stratificationDisease mechanismsTraitsLD matrixOnly summary statisticsUK BiobankPolygenicitySummary statisticsRelatedness
2022
An unbiased kinship estimation method for genetic data analysis
Jiang W, Zhang X, Li S, Song S, Zhao H. An unbiased kinship estimation method for genetic data analysis. BMC Bioinformatics 2022, 23: 525. PMID: 36474154, PMCID: PMC9727941, DOI: 10.1186/s12859-022-05082-2.Peer-Reviewed Original ResearchConceptsRigorous mathematical proofGenetic data analysisReal data analysisUnbiased estimation methodEstimation methodIndividual-level genotype dataSample correlation coefficientMathematical proofMathematical derivationMean square errorCoefficient estimationMatrix methodEstimation accuracyEstimation biasHeritability estimationRoot mean square errorData analysisSquare errorAccurate estimatesEstimationUKINVariances of genotypesSpurious associationsKinship coefficientsEstimates