2022
Evaluation of EEG biomarkers of Comprehensive Behavioral Intervention for Tics in children with Tourette syndrome
Morand-Beaulieu S, Crowley MJ, Grantz H, Leckman JF, Scahill L, Sukhodolsky DG. Evaluation of EEG biomarkers of Comprehensive Behavioral Intervention for Tics in children with Tourette syndrome. Clinical Neurophysiology 2022, 142: 75-85. PMID: 35987093, DOI: 10.1016/j.clinph.2022.07.500.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersChildElectroencephalographyHumansSeverity of Illness IndexTic DisordersTicsTourette SyndromeConceptsClinical Global Impressions-Improvement scaleYale Global Tic Severity ScaleComprehensive Behavioral InterventionGo/NoGo taskTourette syndromeTreatment outcomesEEG coherenceTic severityNoGo taskBehavioral interventionsFirst-line treatmentTic Severity ScaleClinical outcomesMotor areaSeverity ScaleAlpha frequency bandBlinded evaluatorsTic controlMotor responseEEG biomarkersOutcomesSyndromeBrain mechanismsSeverityIntervention
2021
Increased Alpha-Band Connectivity During Tic Suppression in Children With Tourette Syndrome Revealed by Source Electroencephalography Analyses
Morand-Beaulieu S, Wu J, Mayes LC, Grantz H, Leckman JF, Crowley MJ, Sukhodolsky DG. Increased Alpha-Band Connectivity During Tic Suppression in Children With Tourette Syndrome Revealed by Source Electroencephalography Analyses. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2021, 8: 241-250. PMID: 33991741, PMCID: PMC8589865, DOI: 10.1016/j.bpsc.2021.05.001.Peer-Reviewed Original ResearchConceptsTourette syndromeTic suppressionNetwork-based statisticsDefault mode networkCortical regionsRight superior frontal gyrusMode networkAge-mediated increaseFuture treatment studiesSuperior frontal gyrusAlpha-band connectivityChronic motorHigh-density electroencephalographyPhonic ticsLeft precuneusCortical areasBrain regionsTreatment studiesBrain circuitsFunctional connectivityBrain connectivityFrontal gyrusGraph theoretical analysisNeurodevelopmental disordersBrain correlates