2017
Markers of Successful Extubation in Extremely Preterm Infants, and Morbidity After Failed Extubation
Chawla S, Natarajan G, Shankaran S, Carper B, Brion L, Keszler M, Carlo W, Ambalavanan N, Gantz M, Das A, Finer N, Goldberg R, Cotten C, Higgins R, Network E, Jobe A, Caplan M, Polin R, Laptook R, Oh W, Hensman A, Gingras D, Barnett S, Lillie S, Francis K, Andrews D, Angela K, Walsh M, Fanaroff A, Newman N, Siner B, Schibler K, Donovan E, Narendran V, Bridges K, Alexander B, Grisby C, Mersmann M, Mincey H, Hessling J, Goldberg R, Auten K, Fisher K, Foy K, Siaw G, Stoll B, Buchter S, Piazza A, Carlton D, Hale E, Archer S, Poindexter B, Lemons J, Hamer F, Herron D, Miller L, Wilson L, Berberich M, Blaisdell C, Gail D, Kiley J, Poole W, Cunningham M, Hastings B, Irene A, Auman J, Huitema C, Pickett J, Wallace D, Zaterka-Baxter K, Van Meurs K, Stevenson D, Ball M, Proud M, Frantz I, Fiascone J, Furey A, MacKinnon B, Nylen E, Collins M, Cosby S, Phillips V, Rasmussen M, Wozniak P, Rich W, Arnell K, Bridge R, Demetrio C, Bell E, Widness J, Klein J, Johnson K, Duara S, Everett-Thomas R, Watterberg K, Ohls R, Rohr J, Lacy C, Phelps D, Laroia N, Reubens L, Burnell E, Sánchez P, Rosenfeld C, Salhab W, Allen J, Guzman A, Hensley G, Lepps M, Martin M, Miller N, Solis A, Vasil D, Wilder K, Kennedy K, Tyson J, Morris B, Harris B, Lis A, Martin S, McDavid G, Tate P, Wright S, Yoder B, Faix R, Burnett J, Jensen J, Osborne K, Spencer C, Weaver-Lewis K, O'Shea T, Peters N, Sood B, Bara R, Billian E, Johnson M, Ehrenkranz R, Jacobs H, Bhandari V, Cervone P, Gettner P, Konstantino M, Poulsen J, Taft J. Markers of Successful Extubation in Extremely Preterm Infants, and Morbidity After Failed Extubation. The Journal Of Pediatrics 2017, 189: 113-119.e2. PMID: 28600154, PMCID: PMC5657557, DOI: 10.1016/j.jpeds.2017.04.050.Peer-Reviewed Original ResearchConceptsGestational age statusHours of ageSuccessful extubationExtubation failureApgar scoreBronchopulmonary dysplasiaPreterm infantsContinuous positive airway pressure groupOxygenation Randomized TrialExtremely preterm infantsDay of extubationAge statusHigher adjusted ratesEarly surfactantExtubation criteriaExtubation statusFailed ExtubationNeonatal morbidityPreterm neonatesVentilatory strategiesElective extubationWeeks' gestationRandomized trialsAdjusted ratesExtubationPatterns of Oxygenation, Mortality, and Growth Status in the Surfactant Positive Pressure and Oxygen Trial Cohort
Di Fiore J, Martin R, Li H, Morris N, Carlo W, Finer N, Walsh M, Health A, Jobe A, Caplan M, Polin R, Laptook R, Oh W, Hensman A, Gingras D, Barnett S, Lillie S, Francis K, Andrews D, Angela K, Fanaroff A, Newman N, Siner B, Zadell A, Schibler K, Donovan E, Bridges K, Alexander B, Grisby C, Mersmann M, Mincey H, Hessling J, Goldberg R, Cotten C, Wallace D, Freedman S, Auten K, Fisher K, Foy K, Stoll B, Piazza A, Buchter S, Carlton D, Hutchinson A, Hale E, Higgins R, Archer S, Poindexter B, Lemons J, Hamer F, Herron D, Miller L, Wilson L, Berberich M, Blaisdell C, Gail D, Kiley J, Gantz M, Das A, Crawford M, Hastings B, Irene A, Auman J, Huitema C, Pickett J, Wallace D, Zaterka-Baxter K, Van Meurs K, Stevenson D, Ball M, Proud M, Frantz I, Fiascone J, Furey A, MacKinnon B, Nylen E, Ambalavanan N, Collins M, Cosby S, Phillips V, Rasmussen M, Wozniak P, Rich W, Arnell K, Bridge R, Demetrio C, Bell E, Widness J, Klein J, Johnson K, Duara S, Everett-Thomas R, Watterberg K, Ohls R, Rohr J, Lacy C, Phelps D, Laroia N, Markowitz G, Reubens L, Burnell E, Sánchez P, Rosenfeld C, Salhab W, Allen J, Grau L, Guzman A, Hensley G, Lepps M, Martin M, Miller N, Solis A, Vasil D, Wilder K, Kennedy K, Tyson J, Morris B, Harris B, Lis A, Martin S, McDavid G, Tate P, Wright S, Yoder B, Faix R, Burnett J, Jensen J, Osborne K, Spencer C, Weaver-Lewis K, O'Shea T, Peters N, Shankaran S, Sood B, Bara R, Billian E, Johnson M, Ehrenkranz R, Narendran V, Bhandari V, Jacobs H, Cervone P, Gettner P, Konstantino M, Poulsen J, Taft J. Patterns of Oxygenation, Mortality, and Growth Status in the Surfactant Positive Pressure and Oxygen Trial Cohort. The Journal Of Pediatrics 2017, 186: 49-56.e1. PMID: 28279433, PMCID: PMC5484739, DOI: 10.1016/j.jpeds.2017.01.057.Peer-Reviewed Original ResearchConceptsDays of lifeIntermittent hypoxemia eventsOxygen saturation targetsOxygen saturationHypoxemia eventsSaturation targetsGestational ageHigher oxygen saturation targetsExtremely preterm infantsMedian oxygen saturationWeeks of gestationLowest oxygen saturationPositive pressureOxygen saturation levelsPatterns of oxygenationIntermittent hypoxemiaPreterm infantsTrial cohortSupplemental oxygenLowest quartileHigh incidenceTarget infantsInfantsSGASurvival
2001
Defining the specific physiological requirements for c-Myc in T cell development
Douglas N, Jacobs H, Bothwell A, Hayday A. Defining the specific physiological requirements for c-Myc in T cell development. Nature Immunology 2001, 2: 307-315. PMID: 11276201, DOI: 10.1038/86308.Peer-Reviewed Original ResearchConceptsDevelopmental gene expressionC-MycSpecific physiological requirementsMYC family membersT cell developmentAbstractc-MycN-myc expressionGene expressionDeregulated expressionCell developmentCell growthPhysiological requirementsAge-dependent mannerThymocyte maturationDN stageNormal lymphocytesExpressionNonredundant contributionsDistinct patternsFamily membersCellsLymphomagenesisMaturationLymphocytes
1998
Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats
Jacobs H, Bogue C, Pinter E, Wilson C, Warshaw J, Gross I. Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats. Pediatric Research 1998, 44: 99-104. PMID: 9667378, DOI: 10.1203/00006450-199807000-00016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsButyratesButyric AcidDiabetes Mellitus, ExperimentalEmbryonic and Fetal DevelopmentFemaleGene Expression Regulation, DevelopmentalGenes, HomeoboxGestational AgeHistone Deacetylase InhibitorsLungOrgan Culture TechniquesPregnancyPregnancy in DiabeticsRatsRats, Sprague-DawleyRNA, MessengerTranscription, GeneticConceptsLung developmentLung explantsSurfactant apoproteinExperimental animalsLung mRNA levelsElevated levelsEffect of diabetesFetal rat lung explantsLungs of fetusesRat lung explantsEffect of butyrateAntenatal exposureMaternal diabetesMetabolic abnormalitiesStreptozotocin treatmentLower incidenceNormal ratsDiabetesDexamethasoneLevel of expressionRatsTreatment of explantsSodium butyrateMRNA levelsAlters expression
1997
Repeated Doses of the Perfluorocarbon FC-100 Improve Lung Function of Preterm Lambs
Moya F, Llanos A, Ríos A, Riquelme R, Moraga F, Rubio L, Salvo H, Jacobs H. Repeated Doses of the Perfluorocarbon FC-100 Improve Lung Function of Preterm Lambs. Pediatric Research 1997, 42: 893-898. PMID: 9396575, DOI: 10.1203/00006450-199712000-00028.Peer-Reviewed Original ResearchConceptsLung functionPreterm lambsInitial doseIntratracheal administrationFC-100Administration of ExosurfSurfactant-deficient animalsSynthetic surfactant ExosurfArterial blood pressureDynamic lung compliancePreterm neonatesBlood pressureLung complianceSingle doseArterial PO2Arterial PCO2Surfactant deficiencyHeart rateAdditional doseExosurfStudy periodDoseAdministrationDosesSimilar changes
1996
Expression of Hoxb genes in the developing mouse foregut and lung.
Bogue CW, Lou LJ, Vasavada H, Wilson CM, Jacobs HC. Expression of Hoxb genes in the developing mouse foregut and lung. American Journal Of Respiratory Cell And Molecular Biology 1996, 15: 163-171. PMID: 8703472, DOI: 10.1165/ajrcmb.15.2.8703472.Peer-Reviewed Original Research
1990
Effect of artificial surfactant on pulmonary function in preterm and full-term lambs
Gladstone I, Ray A, Salafia C, Perez-Fontan J, Mercurio M, Jacobs H. Effect of artificial surfactant on pulmonary function in preterm and full-term lambs. Journal Of Applied Physiology 1990, 69: 465-472. PMID: 2121700, DOI: 10.1152/jappl.1990.69.2.465.Peer-Reviewed Original ResearchConceptsFunctional residual capacityFull-term lambsMean lung volumePreterm lambsLung volumeResidual capacityTest agentsFC-100Higher minimum surface tensionsRespiratory failureLung functionPulmonary functionLung expansionAlveolar washMinimum surface tensionDynamic complianceArtificial surfactantQualitative histologyOxygenationLambsAgentsGas exchangePretermComplianceHistologyCorticosteroids and Intratracheal Surfactant Both Alter the Distribution between the Airways and Lung Tissue of Intratracheally Administered Radiolabeled Phosphatidylcholine in the Preterm Rabbit
Fiascone J, Mercurio M, Lima D, Jacobs H. Corticosteroids and Intratracheal Surfactant Both Alter the Distribution between the Airways and Lung Tissue of Intratracheally Administered Radiolabeled Phosphatidylcholine in the Preterm Rabbit. Experimental Lung Research 1990, 16: 311-321. PMID: 2394199, DOI: 10.3109/01902149009108847.Peer-Reviewed Original ResearchConceptsIntratracheal surfactantLung tissueAlveolar spaceCorticosteroid exposureMechanical ventilationRinger's lactateAntenatal corticosteroid exposurePrenatal corticosteroid exposurePreterm rabbitsLung clearanceIntratracheal injectionAlveolar lavageDay 25FetusesClearanceVentilationAirwayRadiolabel distributionLactateTissueRabbitsExposureRadiolabelCorticosteroidsLavage
1989
Pulmonary function tests and fluid balance in neonates with chronic lung disease during dexamethasone treatment.
Gladstone I, Ehrenkranz R, Jacobs H. Pulmonary function tests and fluid balance in neonates with chronic lung disease during dexamethasone treatment. Pediatrics 1989, 84: 1072-6. PMID: 2587137, DOI: 10.1542/peds.84.6.1072.Peer-Reviewed Original ResearchConceptsPulmonary function testsChronic lung diseaseFunction testsLung diseaseFluid balanceTotal pulmonary resistanceHours of treatmentFirst dosePulmonary resistanceUrine outputGestational ageRespiratory statusBirth weightExpiratory timeDexamethasone treatmentClinical teamDynamic complianceFluid shiftsInfantsDexamethasoneExtubationSignificant differencesTreatmentDiseaseHoursAntenatal steroids, postnatal surfactant, and pulmonary function in premature rabbits
Gladstone I, Mercurio M, Devenny S, Jacobs H. Antenatal steroids, postnatal surfactant, and pulmonary function in premature rabbits. Journal Of Applied Physiology 1989, 67: 1377-1382. PMID: 2793738, DOI: 10.1152/jappl.1989.67.4.1377.Peer-Reviewed Original ResearchConceptsDynamic compliancePulmonary functionLung resistanceTotal lung conductanceTotal lung resistancePulmonary function testsRespiratory distress syndromeConsistent tidal volumeAntenatal corticosteroidsAntenatal steroidsIntramuscular betamethasonePostnatal surfactantDistress syndromeFunction testsCombination therapyPulmonary mechanicsExpiratory timePremature rabbitsTidal volumeStatic complianceLung conductanceFirst breathDay 27Day 25SteroidsSurface tension and pulmonary compliance in premature rabbits
Mercurio M, Fiascone J, Lima D, Jacobs H. Surface tension and pulmonary compliance in premature rabbits. Journal Of Applied Physiology 1989, 66: 2039-2044. PMID: 2745272, DOI: 10.1152/jappl.1989.66.5.2039.Peer-Reviewed Original Research
1988
Reutilization of surfactant phosphatidylglycerol and lysophosphatidylcholine by adult rabbits
Jacobs H, Lima D, Fiascone J, Mercurio M. Reutilization of surfactant phosphatidylglycerol and lysophosphatidylcholine by adult rabbits. Biochimica Et Biophysica Acta 1988, 962: 227-233. PMID: 3167080, DOI: 10.1016/0005-2760(88)90164-6.Peer-Reviewed Original Research
1985
Reutilization of surfactant phosphatidylcholine in adult rabbits
Jacobs H, Ikegami M, Jobe A, Berry D, Jones S. Reutilization of surfactant phosphatidylcholine in adult rabbits. Biochimica Et Biophysica Acta 1985, 837: 77-84. PMID: 3840389, DOI: 10.1016/0005-2760(85)90087-6.Peer-Reviewed Original Research
1984
A protein from airways of premature lambs that inhibits surfactant function
Ikegami M, Jobe A, Jacobs H, Lam R. A protein from airways of premature lambs that inhibits surfactant function. Journal Of Applied Physiology 1984, 57: 1134-1142. PMID: 6209255, DOI: 10.1152/jappl.1984.57.4.1134.Peer-Reviewed Original ResearchLack of correlation of severity of lung disease with the phosphatidylcholine concentration in fetal lung fluid from premature lambs at 133-136 days gestational age.
Jobe A, Jacobs H, Ikegami M. Lack of correlation of severity of lung disease with the phosphatidylcholine concentration in fetal lung fluid from premature lambs at 133-136 days gestational age. Journal Of Developmental Physiology 1984, 6: 417-21. PMID: 6568247.Peer-Reviewed Original ResearchConceptsFetal lung fluidPeak inspiratory pressureDays gestational ageLung diseaseLung fluidPremature lambsGestational ageInspiratory pressureConcentration of phosphatidylcholinePhosphatidylcholine concentrationNarrow gestational age rangePhosphatidylcholine pool sizesGestational age rangeTime of deliveryLung compliance valuesMechanical ventilationAlveolar washTotal phosphatidylcholineDiseaseAge rangeSeverityLack of correlationAgeLambsCompliance valuesAdrenal Epinephrine and the Regulation of Pulmonary Surfactant Release in Neonatal Rabbits
Padbury J, Jacobs H, Lam R, Conaway D, Jobe A, Fisher D. Adrenal Epinephrine and the Regulation of Pulmonary Surfactant Release in Neonatal Rabbits. Experimental Lung Research 1984, 7: 177-186. PMID: 6549291, DOI: 10.3109/01902148409087911.Peer-Reviewed Original ResearchConceptsAdrenal E contentPulmonary surfactant releaseSKF 29661Surfactant releaseFetal adrenal glandE contentEpinephrine synthesisMaternal doseNeonatal periodAdrenal epinephrineAdrenal glandPregnant rabbitsNeonatal rabbitsAlveolar washPhosphatidylcholine contentBirthRabbitsAgeReleaseEpinephrineDoseSecretion
1982
Premature Lambs Rescued from Respiratory Failure with Natural Surfactant: Clinical and Biophysical Correlates
Jacobs H, Jobe A, Ikegami M, Glatz T, Jones S, Barajas L. Premature Lambs Rescued from Respiratory Failure with Natural Surfactant: Clinical and Biophysical Correlates. Pediatric Research 1982, 16: 424-429. PMID: 6920645, DOI: 10.1203/00006450-198206000-00005.Peer-Reviewed Original ResearchConceptsRespiratory failureDistal airwaysRespiratory distress syndromeMin of ageDays gestational agePressure-volume curvesClinical deteriorationClinical responsePremature lambsDistress syndromePosttreatment groupGestational ageMechanical ventilationProgressive dilatationUntreated lungsPremature babiesTracheal instillationBlood gasAlveolar washSurfactant replacementBody weightLung structureAirwayMinimum surface tensionHistologic measurements