2018
miR-221/222 activate the Wnt/β-catenin signaling to promote triple-negative breast cancer
Liu S, Wang Z, Liu Z, Shi S, Zhang Z, Zhang J, Lin H. miR-221/222 activate the Wnt/β-catenin signaling to promote triple-negative breast cancer. Journal Of Molecular Cell Biology 2018, 10: 302-315. PMID: 30053090, DOI: 10.1093/jmcb/mjy041.Peer-Reviewed Original ResearchConceptsTriple-negative breast cancerWnt/β-cateninMiR-221/222 expressionTNBC cell linesBreast cancerMiR-221/222Β-cateninHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Progression of TNBCGrowth factor receptor 2Limited treatment optionsWnt/β-catenin activationNegative breast cancerFactor receptor 2Primary tumor samplesWnt/β-catenin signalingCell linesWnt3a treatmentMultiple negative regulatorsΒ-catenin activationΒ-catenin signalingPatient survivalPoor prognosisTreatment options
2011
The microRNA regulation of stem cells.
Huang X, Lin H. The microRNA regulation of stem cells. WIREs Mechanisms Of Disease 2011, 1: 83-95. PMID: 23801669, DOI: 10.1002/wdev.5.Peer-Reviewed Original Research
2009
MicroRNAs: key regulators of stem cells
Gangaraju VK, Lin H. MicroRNAs: key regulators of stem cells. Nature Reviews Molecular Cell Biology 2009, 10: 116-125. PMID: 19165214, PMCID: PMC4118578, DOI: 10.1038/nrm2621.Peer-Reviewed Original ResearchConceptsPIWI-interacting RNAsAdult tissue stem cellsStem cell processesTissue stem cellsSmall RNAsStem cellsCell processesNext-generation sequencing technologiesKey protein factorsLong non-coding RNAsNon-coding RNAsNumber of miRNAsGeneration sequencing technologyTranscriptional machineryNew miRNAsAsymmetric divisionDaughter cellsTarget mRNAsProtein factorsMaster regulatorSequencing technologiesKey regulatorUntranslated regionDifferentiation pathwayMiRNAs
2008
Piecing Together the Mosaic of Early Mammalian Development through MicroRNAs*
Blakaj A, Lin H. Piecing Together the Mosaic of Early Mammalian Development through MicroRNAs*. Journal Of Biological Chemistry 2008, 283: 9505-9508. PMID: 18272516, PMCID: PMC2442291, DOI: 10.1074/jbc.r800002200.Peer-Reviewed Original ResearchConceptsRole of miRNAsES cellsEarly mammalian developmentMammalian ES cellsDozens of miRNAsRNase III enzymeCluster of miRNAsES cell differentiationEmbryonic stem cellsRNA biogenesisMammalian embryogenesisMammalian developmentLineage specificationMicroRNA pathwayMiR-290MiRNA biogenesisEmbryonic developmentNuclear proteinsCell differentiationMiRNAsStem cellsBiogenesisEarly developmentCellsCrucial role
2006
MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis
Grivna ST, Pyhtila B, Lin H. MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 13415-13420. PMID: 16938833, PMCID: PMC1569178, DOI: 10.1073/pnas.0605506103.Peer-Reviewed Original ResearchConceptsPIWI-interacting RNAsSmall RNAsTranslational machineryMRNA cap-binding complexArgonaute family proteinsCap-binding complexPIWI family membersPresence of DicerRound spermatidsSubset of miRNAsCytosolic ribonucleoproteinTranslational repressionGene regulationFamily proteinsSubfamily proteinsCytoplasmic proteinsTarget mRNAsMIWIPosttranscriptional levelPolysomal fractionsPolysome fractionsMature spermGene expressionImportant regulatorSpermiogenesisThe Role of PIWI and the miRNA Machinery in Drosophila Germline Determination
Megosh HB, Cox DN, Campbell C, Lin H. The Role of PIWI and the miRNA Machinery in Drosophila Germline Determination. Current Biology 2006, 16: 1884-1894. PMID: 16949822, DOI: 10.1016/j.cub.2006.08.051.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArgonaute ProteinsBody PatterningCell DifferentiationDEAD-box RNA HelicasesDrosophilaDrosophila ProteinsEmbryo, NonmammalianEmbryonic DevelopmentFragile X Mental Retardation ProteinGene Expression Regulation, DevelopmentalGerm CellsMicroRNAsProteinsRibonuclease IIIRNA HelicasesRNA-Induced Silencing ComplexRNA, Small InterferingConceptsGermline determinationDicer-1Dicer-2MiRNA pathwayRole of PiwiReduced PGC numbersNumber of PGCsMiRISC complexesRasiRNA pathwayGermline specificationDrosophila PiwiSiRNA pathwayAbdominal patterningVasa expressionTranslational regulationPGC numberPiwiMiRNA machineryGerm plasmMolecular activityPolar granuleDFMRPCell formationOSKMaternal component