2020
Pumilio proteins utilize distinct regulatory mechanisms to achieve complementary functions required for pluripotency and embryogenesis
Uyhazi KE, Yang Y, Liu N, Qi H, Huang XA, Mak W, Weatherbee SD, de Prisco N, Gennarino VA, Song X, Lin H. Pumilio proteins utilize distinct regulatory mechanisms to achieve complementary functions required for pluripotency and embryogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 7851-7862. PMID: 32198202, PMCID: PMC7148564, DOI: 10.1073/pnas.1916471117.Peer-Reviewed Original ResearchConceptsEmbryonic stem cellsTarget messenger RNAsPumilio proteinsPUM proteinsMessenger RNAEssential functionsStem cell maintenanceDistinct regulatory mechanismsEmbryonic day 8.5ESC pluripotencyTranslational regulatorPluripotency genesGene regulationEarly embryogenesisDifferentiation genesPosttranscriptional levelHigh homologyMRNA stabilityRegulatory mechanismsDouble mutant micePluripotencyDay 8.5Morula stagePluripotency markersEmbryogenesis
2014
Posttranscriptional Regulation of Gene Expression by Piwi Proteins and piRNAs
Watanabe T, Lin H. Posttranscriptional Regulation of Gene Expression by Piwi Proteins and piRNAs. Molecular Cell 2014, 56: 18-27. PMID: 25280102, PMCID: PMC4185416, DOI: 10.1016/j.molcel.2014.09.012.Peer-Reviewed Original ResearchConceptsPIWI-interacting RNAsPIWI proteinsPosttranscriptional regulationPiRNA biogenesisPiRNA pathwayTransposon RNARNA regulationSex determinationCell maintenancePosttranscriptional levelGene expressionDevelopmental transitionsBiological processesProteinRNAGametogenesisRegulationRecent findingsMRNAPotential importancePsuedogenesBiogenesisEmbryogenesisTransposonPathway
2007
piRNAs in the Germ Line
Lin H. piRNAs in the Germ Line. Science 2007, 316: 397-397. PMID: 17446387, DOI: 10.1126/science.1137543.Peer-Reviewed Original Research
2006
MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis
Grivna ST, Pyhtila B, Lin H. MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 13415-13420. PMID: 16938833, PMCID: PMC1569178, DOI: 10.1073/pnas.0605506103.Peer-Reviewed Original ResearchConceptsPIWI-interacting RNAsSmall RNAsTranslational machineryMRNA cap-binding complexArgonaute family proteinsCap-binding complexPIWI family membersPresence of DicerRound spermatidsSubset of miRNAsCytosolic ribonucleoproteinTranslational repressionGene regulationFamily proteinsSubfamily proteinsCytoplasmic proteinsTarget mRNAsMIWIPosttranscriptional levelPolysomal fractionsPolysome fractionsMature spermGene expressionImportant regulatorSpermiogenesis