2024
White matter hyperintensity on MRI and plasma Aβ42/40 ratio additively increase the risk of cognitive impairment in hypertensive adults
de Havenon A, Gottesman R, Willamson J, Rost N, Sharma R, Li V, Littig L, Stulberg E, Falcone G, Prabhakaran S, Schneider A, Sheth K, Pajewski N, Brickman A. White matter hyperintensity on MRI and plasma Aβ42/40 ratio additively increase the risk of cognitive impairment in hypertensive adults. Alzheimer's & Dementia 2024, 20: 6810-6819. PMID: 39229896, PMCID: PMC11485393, DOI: 10.1002/alz.14126.Peer-Reviewed Original ResearchRisk of cognitive impairmentYears of follow-upCognitive impairmentExposure categoriesHigh-risk categoryWhite matter hyperintensitySystolic Blood Pressure Intervention TrialRates of cognitive impairmentSPRINT-MIND trialDementia preventionFollow-upLow-risk categoryMIND trialAdditional risk factorsDevelopment of cognitive impairmentIntervention trialsHypertensive adultsHazard ratioRisk factorsHigh riskLow riskVascular healthTertileRiskImpairment
2023
Impact of genetic polymorphisms on the risk of epilepsy amongst patients with acute brain injury: A systematic review
Misra S, Quinn T, Falcone G, Sharma V, de Havenon A, Zhao Y, Eldem E, French J, Yasuda C, Dawson J, Liebeskind D, Kwan P, Mishra N. Impact of genetic polymorphisms on the risk of epilepsy amongst patients with acute brain injury: A systematic review. European Journal Of Neurology 2023, 30: 1791-1800. PMID: 36912749, DOI: 10.1111/ene.15777.Peer-Reviewed Original ResearchConceptsPost-traumatic epilepsyPost-stroke epilepsyTraumatic brain injuryRisk of epilepsySystematic reviewSingle nucleotide polymorphismsBrain injuryOdds ratioRisk of PSERisk of PTEAcute brain injuryGenetic polymorphismsConfidence intervalsAssociation of SNPsQ-Genie toolPSE patientsLate seizuresHazard ratioStroke patientsTBI patientsPrespecified protocolStudy qualityCurrent evidenceEpilepsyPatients
2022
Effect of Intensive Blood Pressure Control on Incident Stroke Risk in Patients With Mild Cognitive Impairment
de Havenon A, Sharma R, Falcone GJ, Prabhakaran S, Sheth KN. Effect of Intensive Blood Pressure Control on Incident Stroke Risk in Patients With Mild Cognitive Impairment. Stroke 2022, 53: e242-e245. PMID: 35502662, PMCID: PMC9246875, DOI: 10.1161/strokeaha.122.038818.Peer-Reviewed Original ResearchConceptsIntensive BP controlIntensive blood pressure controlMild cognitive impairmentMontreal Cognitive Assessment scoreBlood pressure controlBP controlIncident strokePrimary outcomeCognitive Assessment scoreCognitive impairmentCox modelPressure controlAssessment scoresAnalysis of SPRINTIncident stroke riskStandard BP controlIncident stroke eventsRace/ethnicityBaseline BPRandomization armHazard ratioStroke riskPatient ageStroke eventsAtrial fibrillation
2020
Non-Traumatic Subdural Hemorrhage and Risk of Arterial Ischemic Events
Murthy SB, Wu X, Diaz I, Parasram M, Parikh NS, Iadecola C, Merkler AE, Falcone GJ, Brown S, Biffi A, Ch'ang J, Knopman J, Stieg PE, Navi BB, Sheth KN, Kamel H. Non-Traumatic Subdural Hemorrhage and Risk of Arterial Ischemic Events. Stroke 2020, 51: 1464-1469. PMID: 32178587, PMCID: PMC7188584, DOI: 10.1161/strokeaha.119.028510.Peer-Reviewed Original ResearchConceptsArterial ischemic eventsAcute ischemic strokeIschemic eventsIschemic strokeSubdural hemorrhageMyocardial infarctionAntithrombotic therapyMedicare beneficiariesSDH diagnosisPatient riskSecondary analysisRetrospective cohort studyAcute myocardial infarctionCohort studyHazard ratioSecondary outcomesVascular comorbiditiesPrimary outcomeCox regressionDiagnosis codesClaims dataInternational ClassificationPrimary analysisInfarctionStroke
2019
Antiplatelet Therapy After Spontaneous Intracerebral Hemorrhage and Functional Outcomes
Murthy SB, Biffi A, Falcone GJ, Sansing LH, Torres Lopez V, Navi BB, Roh DJ, Mandava P, Hanley DF, Ziai WC, Kamel H, Rosand J, Sheth KN, Butcher K, Davis S, Gregson B, Lees K, Lyden P, Mayer S, Muir K, Steiner T. Antiplatelet Therapy After Spontaneous Intracerebral Hemorrhage and Functional Outcomes. Stroke 2019, 50: 3057-3063. PMID: 31895618, PMCID: PMC6941441, DOI: 10.1161/strokeaha.119.025972.Peer-Reviewed Original ResearchConceptsAntiplatelet therapyIntracerebral hemorrhageFunctional outcomeHematoma locationCause mortalityMajor disabilityVirtual International Stroke Trials Archive databaseCox proportional regression analysisConclusions Antiplatelet therapyRecurrent intracerebral hemorrhageProportional regression analysisPoor functional outcomeRandomized clinical trialsSpontaneous intracerebral hemorrhagePaucity of dataAntiplatelet medicationsStroke RegistryThromboembolic riskHazard ratioMulticenter cohortPrimary outcomeMedian timeICH patientsClinical trialsMeta-analyzed data
2015
Epidemiology of multiple sclerosis: results from a large observational study in the UK
Jick SS, Li L, Falcone GJ, Vassilev ZP, Wallander M. Epidemiology of multiple sclerosis: results from a large observational study in the UK. Journal Of Neurology 2015, 262: 2033-2041. PMID: 26067217, PMCID: PMC4768220, DOI: 10.1007/s00415-015-7796-2.Peer-Reviewed Original ResearchConceptsUnderlying autoimmune processHazard ratioCause mortalityAutoimmune processMS patientsUK Clinical Practice Research DatalinkClinical Practice Research DatalinkIncident MS casesAdjusted hazard ratioUrinary tract infectionCox proportional regressionMultiple sclerosis progressionPrimary care dataConfidence intervalsLarge observational studiesIdentification of predictorsOriginal medical recordsCurrent smokingPatient comorbiditiesTract infectionsFrequent comorbiditiesLifestyle factorsMS diagnosisMultiple sclerosisPatient group
2014
Mortality of patients with multiple sclerosis: a cohort study in UK primary care
Jick SS, Li L, Falcone GJ, Vassilev ZP, Wallander M. Mortality of patients with multiple sclerosis: a cohort study in UK primary care. Journal Of Neurology 2014, 261: 1508-1517. PMID: 24838537, PMCID: PMC4119255, DOI: 10.1007/s00415-014-7370-3.Peer-Reviewed Original ResearchConceptsCause of deathMS patientsCause mortalityHazard ratioMS casesUK General Practice Research DatabaseGeneral Practice Research DatabaseLarge population-based cohortFirst MS diagnosisMortality of patientsFemale MS patientsCox proportional regressionMultiple sclerosis patientsPopulation-based cohortUK primary careConfidence intervalsDifferent hazard ratiosHR 1.7Index dateCohort studyYounger patientsHigher proportionSclerosis patientsMS diagnosisMultiple sclerosis