2021
Obstructive Sleep Apnea as a Risk Factor for Intracerebral Hemorrhage
Geer JH, Falcone GJ, Vanent KN, Leasure AC, Woo D, Molano JR, Sansing LH, Langefeld CD, Pisani MA, Yaggi HK, Sheth KN. Obstructive Sleep Apnea as a Risk Factor for Intracerebral Hemorrhage. Stroke 2021, 52: 1835-1838. PMID: 33827242, PMCID: PMC8085039, DOI: 10.1161/strokeaha.120.033342.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaRisk factorsBerlin questionnaireIntracerebral hemorrhageSleep apneaEthnic/Racial VariationsHigher body mass indexMultivariable logistic regression modelBody mass indexIntracerebral hemorrhage riskCase-control studyExposure of patientsLogistic regression analysisLogistic regression modelsOSA statusHemorrhage riskMass indexHeart diseaseNontraumatic ICHRacial variationApneaHemorrhageRegression analysisICHRegression models
2019
Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity
Marini S, Crawford K, Morotti A, Lee MJ, Pezzini A, Moomaw CJ, Flaherty ML, Montaner J, Roquer J, Jimenez-Conde J, Giralt-Steinhauer E, Elosua R, Cuadrado-Godia E, Soriano-Tarraga C, Slowik A, Jagiella JM, Pera J, Urbanik A, Pichler A, Hansen BM, McCauley JL, Tirschwell DL, Selim M, Brown DL, Silliman SL, Worrall BB, Meschia JF, Kidwell CS, Testai FD, Kittner SJ, Schmidt H, Enzinger C, Deary IJ, Rannikmae K, Samarasekera N, Salman RA, Sudlow CL, Klijn CJM, van Nieuwenhuizen KM, Fernandez-Cadenas I, Delgado P, Norrving B, Lindgren A, Goldstein JN, Viswanathan A, Greenberg SM, Falcone GJ, Biffi A, Langefeld CD, Woo D, Rosand J, Anderson CD. Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity. JAMA Neurology 2019, 76: 480-491. PMID: 30726504, PMCID: PMC6459133, DOI: 10.1001/jamaneurol.2018.4519.Peer-Reviewed Original ResearchConceptsRace/ethnicityIntracerebral hemorrhageICH riskPotent genetic risk factorApolipoprotein E (APOE) ε4 alleleAPOE allele statusBurden of hypertensionPopulation-based studyPrimary intracerebral hemorrhageIntracerebral hemorrhage riskCase-control studyAssociation of APOEPropensity score analysisGenetic risk factorsWhite participantsRace/ethnic groupsHypertension burdenHemorrhage riskClinical variablesInternational Stroke Genetics ConsortiumRisk factorsSecondary causesΕ2 alleleICH casesApolipoprotein E
2014
Dietary Fiber and Amyotrophic Lateral Sclerosis: Results From 5 Large Cohort Studies
Fondell E, O'Reilly É, Fitzgerald KC, Falcone GJ, Kolonel LN, Park Y, McCullough ML, Ascherio A. Dietary Fiber and Amyotrophic Lateral Sclerosis: Results From 5 Large Cohort Studies. American Journal Of Epidemiology 2014, 179: 1442-1449. PMID: 24816788, PMCID: PMC4051879, DOI: 10.1093/aje/kwu089.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisCohort studyALS riskFiber intakeLateral sclerosisCause of ALSLarge prospective cohort studyRisk of ALSProspective cohort studyHigh fiber intakeMedian survival timeCase-control studyLarge cohort studyProportional hazards modelCohort-specific estimatesRandom-effects modelInflammatory markersProspective studyHighest quintileALS casesDietary intakeCereal fiberSurvival timeLower riskHazards model
2013
Apolipoprotein E, Statins, and Risk of Intracerebral Hemorrhage
Woo D, Deka R, Falcone GJ, Flaherty ML, Haverbusch M, Martini SR, Greenberg SM, Ayres AM, Sauerbeck L, Kissela BM, Kleindorfer DO, Moomaw CJ, Anderson CD, Broderick JP, Rosand J, Langefeld CD, Woo JG. Apolipoprotein E, Statins, and Risk of Intracerebral Hemorrhage. Stroke 2013, 44: 3013-3017. PMID: 24008570, PMCID: PMC3873717, DOI: 10.1161/strokeaha.113.001304.Peer-Reviewed Original ResearchConceptsRisk of ICHLobar intracerebral hemorrhageStatin useIntracerebral hemorrhageReplication cohortICH casesAssociation of hypercholesterolemiaHemorrhagic Stroke studyNonlobar intracerebral hemorrhageCase-control studyApolipoprotein E genotypeFisher's exact testEnvironmental risk factorsBreslow-Day testHemorrhagic strokeStroke StudyRisk factorsClinical changesE4 genotypeAPOE polymorphismE genotypeApolipoprotein EDiscovery cohortHigh riskLower riskMagnesium intake and risk of amyotrophic lateral sclerosis: Results from five large cohort studies
Fondell E, O’Reilly É, Fitzgerald KC, Falcone GJ, McCullough ML, Park Y, Kolonel LN, Ascherio A. Magnesium intake and risk of amyotrophic lateral sclerosis: Results from five large cohort studies. Amyotrophic Lateral Sclerosis And Frontotemporal Degeneration 2013, 14: 356-361. PMID: 23777266, PMCID: PMC3743429, DOI: 10.3109/21678421.2013.803577.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisMagnesium intakeALS riskCohort studyLateral sclerosisCases of ALSLarge prospective cohort studyProspective cohort studyDietary magnesium intakeLow magnesium intakeCase-control studyLarge cohort studyProportional hazards modelCohort-specific estimatesRandom-effects modelProspective studyHighest quintileDietary intakeProtective effectHazards modelIntakeMagnesium absorptionSclerosisHeavy metal exposureRisk
2012
Burden of Risk Alleles for Hypertension Increases Risk of Intracerebral Hemorrhage
Falcone GJ, Biffi A, Devan WJ, Jagiella JM, Schmidt H, Kissela B, Hansen BM, Jimenez-Conde J, Giralt-Steinhauer E, Elosua R, Cuadrado-Godia E, Soriano C, Ayres AM, Schwab K, Pera J, Urbanik A, Rost NS, Goldstein JN, Viswanathan A, Pichler A, Enzinger C, Norrving B, Tirschwell DL, Selim M, Brown DL, Silliman SL, Worrall BB, Meschia JF, Kidwell CS, Montaner J, Fernandez-Cadenas I, Delgado P, Broderick JP, Greenberg SM, Roquer J, Lindgren A, Slowik A, Schmidt R, Flaherty ML, Kleindorfer DO, Langefeld CD, Woo D, Rosand J. Burden of Risk Alleles for Hypertension Increases Risk of Intracerebral Hemorrhage. Stroke 2012, 43: 2877-2883. PMID: 22933587, PMCID: PMC3479325, DOI: 10.1161/strokeaha.112.659755.Peer-Reviewed Original ResearchConceptsRisk of ICHBlood pressure levelsIntracerebral hemorrhageGenetic risk scoreUnweighted genetic risk scoreRisk scoreProspective multicenter case-control studyMulticenter case-control studyHistory of hypertensionLobar intracerebral hemorrhageDeep intracerebral hemorrhagePotent risk factorCase-control studyLogistic regression modelsControl subjectsRisk factorsICH casesHypertensionIncrease riskCumulative burden