1991
Propranolol in the prevention of the first hemorrhage from esophagogastric varices: A multicenter, randomized clinical trial
Conn H, Grace N, Bosch J, Groszmann R, Rodés J, Wright S, Matloff D, Garcia‐Tsao G, Fisher R, Navasa M, Drewniak S, Atterbury C, Bordas J, Lerner E, Bramante C. Propranolol in the prevention of the first hemorrhage from esophagogastric varices: A multicenter, randomized clinical trial. Hepatology 1991, 13: 902-912. PMID: 2029994, DOI: 10.1002/hep.1840130517.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientVenous pressure gradientPlacebo groupPropranolol groupEsophageal varicesVariceal hemorrhageChild class AEffectiveness of propranololFirst variceal hemorrhageInitial variceal hemorrhageCessation of therapyPortal hypertensive gastropathyChild class BDoses of propranololLarge esophageal varicesHepatic vein cathetersBeats/minClass BPlacebo patientsPropranolol patientsAlcoholic cirrhosisHypertensive gastropathyMean followMedian doseLarge varices
1990
Hemodynamic events in a prospective randomized trial of propranolol versus placebo in the prevention of a first variceal hemorrhage
Groszmann R, Bosch J, Grace N, Conn H, Garcia-Tsao G, Navasa M, Alberts J, Rodes J, Fischer R, Bermann M, Rofe S, Patrick M, Lerner E. Hemodynamic events in a prospective randomized trial of propranolol versus placebo in the prevention of a first variceal hemorrhage. Gastroenterology 1990, 99: 1401-1407. PMID: 2210246, DOI: 10.1016/0016-5085(90)91168-6.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientVenous pressure gradientVariceal hemorrhageEsophageal varicesHemodynamic eventsBaseline valuesHeart rateFirst variceal hemorrhagePropranolol-treated groupPropranolol-treated patientsTrial of propranololAdministration of propranololBeginning of therapyRate of survivalPortal hypertensionVariceal bleedingCirrhotic patientsPharmacological therapyVariceal sizeProtective effectMortality ratePatientsPlaceboPropranololVarices