2023
Mortality, incarceration and cost implications of fentanyl felonization laws: A modeling study
Savinkina A, Jurecka C, Gonsalves G, Barocas J. Mortality, incarceration and cost implications of fentanyl felonization laws: A modeling study. International Journal Of Drug Policy 2023, 121: 104175. PMID: 37729682, PMCID: PMC10840895, DOI: 10.1016/j.drugpo.2023.104175.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidDrug OverdoseFentanylHumansOpiate OverdoseOpioid-Related DisordersUnited StatesOutbreaks in U.S. Migrant Detention Centers — A Vaccine-Preventable Cause of Health Inequity
Lo N, Gonsalves G. Outbreaks in U.S. Migrant Detention Centers — A Vaccine-Preventable Cause of Health Inequity. New England Journal Of Medicine 2023, 389: 679-681. PMID: 37602574, DOI: 10.1056/nejmp2304716.Peer-Reviewed Original ResearchEarly OxyContin Marketing Linked To Long-Term Spread Of Infectious Diseases Associated With Injection Drug Use
Dennett J, Gonsalves G. Early OxyContin Marketing Linked To Long-Term Spread Of Infectious Diseases Associated With Injection Drug Use. Health Affairs 2023, 42: 1081-1090. PMID: 37467441, PMCID: PMC10521060, DOI: 10.1377/hlthaff.2023.00146.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidCommunicable DiseasesDrug OverdoseHumansMarketingOpioid-Related DisordersOxycodoneUnited StatesConceptsInjection drug useDrug useAdverse long-term outcomesInfectious diseasesReformulation of OxyContinAcute hepatitis ALong-term outcomesOpioid-related overdosesInitial marketingFatal drug overdosesBacterial complicationsHepatitis ADrug overdosesEffects of exposureOpioid epidemicViral infectionGreater burdenIllicit drugsLow exposureComplicationsHigh exposureOverdosesOutcomesDiseaseOxyContinPatterns of Infectious Disease Associated With Injection Drug Use in Massachusetts
Gonsalves G, Paltiel A, Thornhill T, DeMaria A, Cranston K, Klevens R, Warren J. Patterns of Infectious Disease Associated With Injection Drug Use in Massachusetts. Clinical Infectious Diseases 2023, 76: 2134-2139. PMID: 36757712, PMCID: PMC10273381, DOI: 10.1093/cid/ciad073.Peer-Reviewed Original ResearchConceptsSoft tissue infectionsHuman immunodeficiency virusHepatitis C virusInjection drug useHCV casesInfective endocarditisHIV casesDrug useSubstance use disordersLogistic regression modelsClinical sequalaeSSTI casesPublic health crisisTissue infectionsImmunodeficiency virusDisease AssociatedHIV outbreakAbscess incisionC virusUse disordersInfectious diseasesInfectionMultiple outbreaksMedical proceduresSuch associationsPlanning for Mpox on a College Campus: A Model-Based Decision-Support Tool.
Savinkina A, Chitwood M, Kwon J, Pitzer V, Gonsalves G, Paltiel A. Planning for Mpox on a College Campus: A Model-Based Decision-Support Tool. Annals Of Internal Medicine 2023, 176: 340-347. PMID: 36716454, PMCID: PMC10338074, DOI: 10.7326/m22-2734.Peer-Reviewed Original ResearchMeSH KeywordsCOVID-19Homosexuality, MaleHumansMaleMonkeypoxSexual and Gender MinoritiesUnited StatesUniversitiesConceptsSustained transmissionNational InstituteLow-risk groupHigh-risk populationPopulation of MSMHealth-National InstituteResidential college campusSymptomatic casesHypothetical cohortCongregate settingsStudy populationPreemptive vaccinationReactive vaccinationInfectious diseasesVaccinationDrug abuseBasic reproductive numberFuture outbreaksFrequent physical contactMSMReproductive numberOutbreakDaysMenTimely detectionEstimated Testing, Tracing, and Vaccination Targets for Containment of the US Mpox Outbreak
Chitwood M, Kwon J, Savinkina A, Walker J, Bilinski A, Gonsalves G. Estimated Testing, Tracing, and Vaccination Targets for Containment of the US Mpox Outbreak. JAMA Network Open 2023, 6: e2250984. PMID: 36637825, PMCID: PMC9857202, DOI: 10.1001/jamanetworkopen.2022.50984.Peer-Reviewed Original Research
2022
Prioritization of carceral spending in U.S. cities: Development of the Carceral Resource Index (CRI) and the role of race and income inequality
Skaathun B, Maviglia F, Vo A, McBride A, Seymour S, Mendez S, Gonsalves G, Beletsky L. Prioritization of carceral spending in U.S. cities: Development of the Carceral Resource Index (CRI) and the role of race and income inequality. PLOS ONE 2022, 17: e0276818. PMID: 36520883, PMCID: PMC9754598, DOI: 10.1371/journal.pone.0276818.Peer-Reviewed Original ResearchConceptsCarceral systemRole of raceU.S. citiesLarge U.S. citiesTerms of incomeSocial supportCarceral institutionsStructural racismBudgetary prioritiesEconomic disparitiesEthnic compositionBudget prioritiesGovernment investmentBlack residentsWhite residentsPopulation concentrationSocial conflict modelIncome inequalityBudgetary investmentsEconomic profileInvestment prioritiesSupportive servicesConflict modelStrong prioritizationResource index
2021
Understanding the Barriers to Pooled SARS-CoV-2 Testing in the United States
Fenichel EP, Koch RT, Gilbert A, Gonsalves G, Wyllie AL. Understanding the Barriers to Pooled SARS-CoV-2 Testing in the United States. Microbiology Spectrum 2021, 9: 10.1128/spectrum.00312-21. PMID: 34378949, PMCID: PMC8552767, DOI: 10.1128/spectrum.00312-21.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 testingSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detectionPooled testingPooled testing strategyClinical Laboratory Improvement AmendmentsTraditional diagnostic testingEmergence of variantsTesting strategiesDiagnostic testingVirus resurgenceEarly detectionClear protocolsTest capacityTesting capacityUnited StatesTest priceSurveillance measuresTest reportingMajor barrierUptakeAdequate resourcesResponseTestingTesting programU.S. laboratoriesHealth Care Utilization Before and After the “Muslim Ban” Executive Order Among People Born in Muslim-Majority Countries and Living in the US
Samuels EA, Orr L, White EB, Saadi A, Padela AI, Westerhaus M, Bhatt AD, Agrawal P, Wang D, Gonsalves G. Health Care Utilization Before and After the “Muslim Ban” Executive Order Among People Born in Muslim-Majority Countries and Living in the US. JAMA Network Open 2021, 4: e2118216. PMID: 34328502, PMCID: PMC8325073, DOI: 10.1001/jamanetworkopen.2021.18216.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAmbulatory Care FacilitiesAppointments and SchedulesEmergency Service, HospitalEmigrants and ImmigrantsEmigration and ImmigrationFemaleHumansIslamMaleMiddle AgedMinnesotaPatient Acceptance of Health CarePrimary Health CareRefugeesRetrospective StudiesUnited StatesYoung AdultConceptsPrimary care appointmentsHealth care utilizationED visitsCare appointmentsCohort studyCare utilizationEmergency departmentGroup 1Primary care clinic visitsAdditional ED visitsRetrospective cohort studyPrimary care visitsPrimary care clinicsCare visitsAdult patientsClinic visitsPrimary outcomeCare clinicsStudy groupMAIN OUTCOMEGroup 2Group 3Visit trendsPatientsVisitsExpanding access to methadone treatment in Ohio through federally qualified health centers and a chain pharmacy: A geospatial modeling analysis
Iloglu S, Joudrey PJ, Wang EA, Thornhill TA, Gonsalves G. Expanding access to methadone treatment in Ohio through federally qualified health centers and a chain pharmacy: A geospatial modeling analysis. Drug And Alcohol Dependence 2021, 220: 108534. PMID: 33497963, PMCID: PMC7901120, DOI: 10.1016/j.drugalcdep.2021.108534.Peer-Reviewed Original ResearchConceptsFederally Qualified Health CentersOpioid treatment programsOpioid use disorderQualified health centersProportion of needHealth centersZip codesTreatment needsMethadone provisionChain pharmaciesRural-Urban Commuting Area codesProvision of methadoneOpioid overdose deathsRural classificationDrive timeMethadone administrationPrimary outcomeOUD treatmentMethadone treatmentUrban-rural strataOverdose deathsUse disordersTreatment programGeospatial modeling analysisOne-thirdEviction, Health Inequity, and the Spread of COVID-19: Housing Policy as a Primary Pandemic Mitigation Strategy
Benfer EA, Vlahov D, Long MY, Walker-Wells E, Pottenger JL, Gonsalves G, Keene D. Eviction, Health Inequity, and the Spread of COVID-19: Housing Policy as a Primary Pandemic Mitigation Strategy. Journal Of Urban Health 2021, 98: 1-12. PMID: 33415697, PMCID: PMC7790520, DOI: 10.1007/s11524-020-00502-1.Peer-Reviewed Original ResearchConceptsNon-Hispanic whitesHealth inequitiesPandemic mitigation strategiesInfection rateCOVID-19COVID-19 infectionCOVID-19 infection ratesRacial health inequitiesNegative health effectsSupportive measuresHealth outcomesLow-income populationsHealth effectsUnprecedented unemployment ratesPandemic control strategiesDecreased abilityCOVID-19 pandemicPublic healthRecent dataCOVID-19 spreadDisproportionate ratesPrevention policiesPreventionDeathRecent studies
2020
Preventing the Spread of COVID-19 in Immigration Detention Centers Requires the Release of Detainees.
Lopez WD, Kline N, LeBrón AMW, Novak NL, De Trinidad Young ME, Gonsalves G, Mishori R, Safi BA, Kysel IM. Preventing the Spread of COVID-19 in Immigration Detention Centers Requires the Release of Detainees. American Journal Of Public Health 2020, 111: 110-115. PMID: 33211577, PMCID: PMC7750591, DOI: 10.2105/ajph.2020.305968.Peer-Reviewed Original ResearchMeSH KeywordsAdultChildCOVID-19Emigration and ImmigrationHumansJailsTransients and MigrantsUnited StatesPolitical interference in public health science during covid-19
Gonsalves G, Yamey G. Political interference in public health science during covid-19. The BMJ 2020, 371: m3878. PMID: 33023874, DOI: 10.1136/bmj.m3878.Peer-Reviewed Original ResearchDonald Trump: a political determinant of covid-19
Yamey G, Gonsalves G. Donald Trump: a political determinant of covid-19. The BMJ 2020, 369: m1643. PMID: 32332028, DOI: 10.1136/bmj.m1643.Peer-Reviewed Original Research
2019
Suspected heroin-related overdoses incidents in Cincinnati, Ohio: A spatiotemporal analysis
Li ZR, Xie E, Crawford FW, Warren JL, McConnell K, Copple JT, Johnson T, Gonsalves GS. Suspected heroin-related overdoses incidents in Cincinnati, Ohio: A spatiotemporal analysis. PLOS Medicine 2019, 16: e1002956. PMID: 31714940, PMCID: PMC6850525, DOI: 10.1371/journal.pmed.1002956.Peer-Reviewed Original ResearchConceptsRisk of overdoseRisk of incidentBlock groupHarm reduction measuresPoisson regression modelsHighest overdose ratesOpioid misuseRisk factorsOpioid epidemicOpiate overdosesOverdose incidentsOpioid overdosesOverdose ratesNature of incidentsEmergency callsMale populationMedian household incomeTreatment programOverdose emergencyHealth policySpatiotemporal risk factorsLack of informationDemographic characteristicsHigher numberOverdosesMedicare Spending on Drugs and Biologics Not Recommended for Coverage by International Health Technology Assessment Agencies
Egilman AC, Wallach JD, Dhruva SS, Gonsalves GS, Ross JS. Medicare Spending on Drugs and Biologics Not Recommended for Coverage by International Health Technology Assessment Agencies. Journal Of General Internal Medicine 2019, 34: 2319-2321. PMID: 31313117, PMCID: PMC6848610, DOI: 10.1007/s11606-019-05149-6.Peer-Reviewed Original Research
2018
Comparison of treatment effect sizes from pivotal and postapproval trials of novel therapeutics approved by the FDA based on surrogate markers of disease: a meta-epidemiological study
Wallach JD, Ciani O, Pease AM, Gonsalves GS, Krumholz HM, Taylor RS, Ross JS. Comparison of treatment effect sizes from pivotal and postapproval trials of novel therapeutics approved by the FDA based on surrogate markers of disease: a meta-epidemiological study. BMC Medicine 2018, 16: 45. PMID: 29562926, PMCID: PMC5863466, DOI: 10.1186/s12916-018-1023-9.Peer-Reviewed Original ResearchConceptsPostapproval trialsPivotal trialsActual clinical effectSurrogate markerTrial endpointsLarge treatment effectsPrimary endpointNovel therapeuticsNovel drugsTreatment effectsFDA approvalPatient-relevant outcomesMeta-epidemiological studyStandardized mean differenceTreatment effect sizeClinical effectsResultsBetween 2005Odds ratioDrug trialsSame indicationDrug AdministrationEvidence of differencesMean differenceU.S. FoodDisease
2017
A Flow-Based Model of the HIV Care Continuum in the United States
Gonsalves GS, Paltiel AD, Cleary PD, Gill MJ, Kitahata MM, Rebeiro PF, Silverberg MJ, Horberg M, Abraham AG, Althoff KN, Moore R, Bosch RJ, Tang T, Hall HI, Kaplan EH. A Flow-Based Model of the HIV Care Continuum in the United States. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2017, 75: 548-553. PMID: 28471841, PMCID: PMC5533168, DOI: 10.1097/qai.0000000000001429.Peer-Reviewed Original ResearchConceptsViral suppressionAntiretroviral therapyHIV careNorth American AIDS Cohort CollaborationProportion of HIVHIV care continuumCohort CollaborationHIV diagnosisAntiretroviral treatmentVirological dataCare continuumFlow of patientsDisease controlPatientsCareAverage timeHIVTherapyLaboratory resultsMonthsSuppressionYearsDiagnosisIndividualsPrevention
2016
New Hepatitis C Drugs Are Very Costly And Unavailable To Many State Prisoners
Beckman AL, Bilinski A, Boyko R, Camp GM, Wall AT, Lim JK, Wang EA, Bruce RD, Gonsalves GS. New Hepatitis C Drugs Are Very Costly And Unavailable To Many State Prisoners. Health Affairs 2016, 35: 1893-1901. PMID: 27702964, DOI: 10.1377/hlthaff.2016.0296.Peer-Reviewed Original ResearchConceptsHepatitis C epidemicHepatitis CC epidemicDrug discount programsLedipasvir/sofosbuvirTwelve-week courseNew hepatitis C drugsHealth care facilitiesHepatitis C drugsAntiviral medicationsCare facilitiesC drugsMedicationsSofosbuvirDiscount programPharmaceutical companiesEpidemicDepartmentDepartment of CorrectionsAntiviralsState prisonersState prisonsRelease
2015
Commentary: Will 20th century patient safeguards be reversed in the 21st century?
Gonsalves G, Zuckerman D. Commentary: Will 20th century patient safeguards be reversed in the 21st century? The BMJ 2015, 350: h1500. PMID: 25814537, DOI: 10.1136/bmj.h1500.Peer-Reviewed Original Research