2000
Rate of caudate atrophy in presymptomatic and symptomatic stages of Huntington's disease
Aylward E, Codori A, Rosenblatt A, Sherr M, Brandt J, Stine O, Barta P, Pearlson G, Ross C. Rate of caudate atrophy in presymptomatic and symptomatic stages of Huntington's disease. Movement Disorders 2000, 15: 552-560. PMID: 10830423, DOI: 10.1002/1531-8257(200005)15:3<552::aid-mds1020>3.0.co;2-p.Peer-Reviewed Original ResearchConceptsUseful outcome measureCaudate volumeHuntington's diseaseSymptomatic patientsSymptomatic subjectsCaudate atrophyOutcome measuresLongitudinal changesStages of HDMean interscan intervalSerial magnetic resonance imagesHD gene mutationNeurological examSymptomatic groupModerate symptomsMild symptomsSymptomatic stagePresymptomatic carriersTherapeutic studiesTreatment effectivenessPatientsMagnetic resonance imagesDiseaseGene mutationsInterscan interval
1997
Quantification of Neuroreceptors in the Living Human Brain
Wong *, Pearlson ‡, Tune ‡, Young *, Meltzer *, Dannals *, Ravert *, Reith *, Kuhar †, Gjedde ¶. Quantification of Neuroreceptors in the Living Human Brain. Cerebrovascular And Brain Metabolism Reviews 1997, 17: 331-342. PMID: 9119906, DOI: 10.1097/00004647-199703000-00010.Peer-Reviewed Original ResearchConceptsD2-like dopamine receptorsDrug-naive schizophrenic patientsDopamine receptorsSchizophrenic patientsIllness patientsPatient groupControl subjectsReceptor densityD2 dopamine receptor densityDrug-naive schizophreniaDopamine receptor densityLiving Human BrainBipolar affective illnessD2 dopamine receptorsQuantification of NeuroreceptorsPositron emission tomographyEffect of ageBrain uptakeAffective illnessBipolar illnessNonpsychotic patientsCaudate nucleusNormal controlsNormal volunteersPatients
1995
In Vivo D2 Dopamine Receptor Density in Psychotic and Nonpsychotic Patients With Bipolar Disorder
Pearlson G, Wong D, Tune L, Ross C, Chase G, Links J, Dannals R, Wilson A, Ravert H, Wagner H, DePaulo J. In Vivo D2 Dopamine Receptor Density in Psychotic and Nonpsychotic Patients With Bipolar Disorder. JAMA Psychiatry 1995, 52: 471-477. PMID: 7771917, DOI: 10.1001/archpsyc.1995.03950180057008.Peer-Reviewed Original ResearchConceptsSchizophrenic patientsBipolar disorderBmax valuesNonpsychotic patientsNormal controlsPsychotic symptomsPsychotic patientsAffective disordersPositron emission tomographic scansD2 dopamine receptor densityNeuroleptic-naive schizophrenic patientsPositron emission tomographic studiesDopamine receptor densityReceptor density valuesDSM-III criteriaPresent State ExaminationPresence of psychosisEmission tomographic studiesHigher Bmax valuesPsychotic bipolar disorderNeuroleptic medicationReceptor BmaxMood abnormalitiesReceptor valuesTomographic scan
1993
Single Photon Emission Computed Tomography in Obsessive-Compulsive Disorder
Harris G, Pearlson G, Hoehn-Saric R. Single Photon Emission Computed Tomography in Obsessive-Compulsive Disorder. JAMA Psychiatry 1993, 50: 498-499. PMID: 8498888, DOI: 10.1001/archpsyc.1993.01820180100015.Peer-Reviewed Original ResearchConceptsOrbital frontal regionsObsessive-compulsive disorderSingle photon emissionBlood flowRegional cerebral blood flowCortical blood flowGroup of patientsCerebral blood flowMedial frontal regionsSPECT studiesAnatomical locationPatientsCompulsive disorderPhoton emissionEt al1DisordersTomographyGroup
1992
Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntington's disease
Harris G, Pearlson G, Peyser C, Aylward E, Roberts J, Barta P, Chase G, Folstein S. Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntington's disease. Annals Of Neurology 1992, 31: 69-75. PMID: 1531910, DOI: 10.1002/ana.410310113.Peer-Reviewed Original ResearchConceptsMild Huntington's diseaseBicaudate ratioCaudate atrophyHuntington's diseaseHD patientsControl subjectsCaudate volumePutamen volumeSex-matched control subjectsNeurological examination scoresPutamen volume reductionsCharacteristic pathological featuresModerate Huntington's diseaseMagnetic resonance imagingCaudate changesNeostriatal atrophyNeuronal lossNeuroradiological studiesComputerized image analysis systemPathological featuresGreater atrophyBrain abnormalitiesCaudate nucleusAtrophyPatients
1991
Bicaudate ratio as a measure of caudate volume on MR images.
Aylward E, Schwartz J, Machlin S, Pearlson G. Bicaudate ratio as a measure of caudate volume on MR images. American Journal Of Neuroradiology 1991, 12: 1217-22. PMID: 1763757, PMCID: PMC8331458.Peer-Reviewed Original Research
1986
Positron Emission Tomography Reveals Elevated D2 Dopamine Receptors in Drug-Naive Schizophrenics
Wong D, Wagner H, Tune L, Dannals R, Pearlson G, Links J, Tamminga C, Broussolle E, Ravert H, Wilson A, Toung J, Malat J, Williams J, O'Tuama L, Snyder S, Kuhar M, Gjedde A. Positron Emission Tomography Reveals Elevated D2 Dopamine Receptors in Drug-Naive Schizophrenics. Science 1986, 234: 1558-1563. PMID: 2878495, DOI: 10.1126/science.2878495.Peer-Reviewed Original ResearchConceptsD2 dopamine receptorsD2 dopamine receptor densityPositron emission tomographyGroup of patientsDopamine receptor densityDopamine receptorsCaudate nucleusReceptor densityNormal volunteersEmission tomographyDrug-naive schizophrenicsNumber of receptorsMost patientsBasal gangliaNeuroleptic drugsPostmortem studiesBiochemical abnormalitiesPatientsPsychiatric diseasesSchizophreniaReceptorsDrugsVolunteersTomographyGroup
1985
Dopamine receptor binding of C-11-3-N-methylspiperone in the caudate in schizophrenia and bipolar disorder: a preliminary report.
Wong D, Wagner H, Pearlson G, Dannals R, Links J, Ravert H, Wilson A, Suneja S, Bjorvvinssen E, Kuhar M. Dopamine receptor binding of C-11-3-N-methylspiperone in the caudate in schizophrenia and bipolar disorder: a preliminary report. Psychopharmacology Bulletin 1985, 21: 595-8. PMID: 4034877.Peer-Reviewed Original ResearchMeSH KeywordsAdultBipolar DisorderButyrophenonesCaudate NucleusHumansReceptors, DopamineSchizophreniaSpiperoneConceptsDopamine receptor binding
1984
Effect of anterior-posterior lesion location on the asymmetrical behavioral and biochemical response to cortical suction ablations in the rat
Pearlson G, Kubos K, Robinson R. Effect of anterior-posterior lesion location on the asymmetrical behavioral and biochemical response to cortical suction ablations in the rat. Brain Research 1984, 293: 241-250. PMID: 6697218, DOI: 10.1016/0006-8993(84)91231-9.Peer-Reviewed Original ResearchConceptsSuction ablationLesion locationRight hemisphereConcentrations of norepinephrineContralateral cortexCortical lesionsAnterior lesionsLocus coeruleusSpontaneous activityNeurotransmitter pathwaysLocomotor activityGreater reductionLesionsRatsCortexBehavioral findingsBiochemical responsesAblationAnalysis of varianceAnterior-posterior axisNorepinephrineCoeruleusHyperactivityHemisphere
1982
Intracortical kainic acid induces an assymmetrical behavioral response in the rat
Kubos K, Pearlson G, Robinson R. Intracortical kainic acid induces an assymmetrical behavioral response in the rat. Brain Research 1982, 239: 303-309. PMID: 7093686, DOI: 10.1016/0006-8993(82)90857-5.Peer-Reviewed Original ResearchConceptsKainic acidCortical noradrenergic terminalsDay postoperative periodRight frontal cortexNoradrenergic terminalsPostoperative periodRight hemisphere lesionsSpontaneous hyperactivityFrontal cortexIdentical injectionsHemisphere lesionsNanomolar dosesLeft hemisphereHyperactivityRatsNeural asymmetriesInjectionBehavioral responsesPrevious studiesLesionsCortexDosesWeeks